Tiia Kärkkäinen
MSc
tmakar@utu.fi ORCID-tunniste: https://orcid.org/0000-0003-0041-6738 |
Tutkimus
Telomeres are non-coding DNA-sequences at the end of chromosomes and their main function is to protect genome from damage. Telomeres shorten with every cell division, but external factors can accelerate the shortening through oxidative stress. Short telomeres are shown to increase the risk of cancer and other age-related diseases. Furthermore, inter-individual variation in telomere length explains inter-individual differences in, i.a., lifespan, susceptibility to disease and ability to handle stress.
In my PhD, I am investigating within-individual changes and inter-individual differences in telomere length as well as the factors that may drive these differences using pied flycatcher as a model species. Studies about telomere dynamics have rapidly increased in number during recent years. Although, traditional telomere research is mainly correlative even if only experimental research allows us to see the underlying causes behind the individual differences and subsequent survival probabilities. Telomere length is also about to be established as a biomarker of long-term costs but there is no research focusing on individual consistency in telomere measurements which should be required for telomere length to be useful in this purpose.
In my thesis, I aim to fill in this gap and to provide a solid basis for future studies using telomere length as a proxy for individual state. My research will also provide new information about how individual telomere lengths are determined in early life as well as how different life-history events affect telomere dynamics in later life.
In my thesis, I aim to fill in this gap and to provide a solid basis for future studies using telomere length as a proxy for individual state. My research will also provide new information about how individual telomere lengths are determined in early life as well as how different life-history events affect telomere dynamics in later life.
Julkaisut
- Winter-ground microhabitat use by differently coloured phenotypes affects return rate in a long-distance migratory bird (2024)
- Oecologia
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Population differences in the length and early-life dynamics of telomeres among European pied flycatchers (2022)
- Molecular Ecology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Species-specific song responses emerge as a by-product of tuning to the local dialect (2022)
- Current Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Within-individual repeatability in telomere length: A meta-analysis in nonmammalian vertebrates (2022)
- Molecular Ecology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Interplays between pre- and post-natal environments affect early-life mortality, body mass and telomere dynamics in the wild (2021)
- Journal of Experimental Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Correlation in telomere lengths between feathers and blood cells in pied flycatchers (2020)
- Journal of Avian Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Lifestyle and environment affecting telomere dynamics in a long-distance migratory passerine (2020) Kärkkäinen Tiia
(G5 Artikkeliväitöskirja) - Impact of continuous predator threat on telomere dynamics in parent and nestling pied flycatchers (2019)
- Oecologia
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )