Adjunct professor, MD, Gynecologic oncologist Johanna Hynninen - UTU Research Portal

Johanna Hynninen
Adjunct professor, MD, Gynecologic oncologist

- Docent,
Department of Clinical Medicine (Faculty of Medicine)
- ,
Obstetrics and Gynaecology (Department of Clinical Medicine)

mijohy@utu.fi

ORCID identifier: https://orcid.org/0000-0002-0854-7225

Areas of expertise

gynaecologic oncology; ovarian cancer

Research community or research topic

https://sites.utu.fi/ovariancancer/ https://www.deciderproject.eu

Publications

2 of 5

Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma (2023)
- Cancer Cell
Lahtinen Alexandra, Lavikka Kari, Virtanen Anni, Li Yilin, Jamalzadeh Sanaz, Skorda Aikaterini, Lauridsen Anna Rössberg, Zhang Kaiynag, Marchi Giovanni, Isoviita Veli-Matti, Ariotta Valeria, Lehtonen Oskari, Muranen Taru A., Huhtinen Kaisa, Carpén Olli, Hietanen Sakari, Senkowski Wojciech, Kallunki Tuula, Häkkinen Aantti, Hynninen Johanna, Oikkonen Jaana, Hautaniemi Sampsa
(A1 Refereed original research article in a scientific journal)
Evolutionary study identifies poor prognosis HGSC patients and reveals clinically relevant targets at diagnosis and relapse (2023)
- International Journal of Gynecological Cancer
Oikkonen, Jaana; Lahtinen, Alexandra; Lavikka, Kari; Virtanen, Anni; Li, Yilin; Jamalzadeh, Sanaz; Skorda, Aikaterini; Lauridsen, Anna Rossberg; Zhang, Kaiyang; Marchi, Giovanni; Nguyen, Mai T. N.; Rajavuori, Anna; Muranen, Taru A.; Huhtinen, Kaisa; Hietanen, Sakari; Senkowski, Wojciech; Kallunki, Tuula; Hakkinen, Antti; Hynninen, Johanna; Hautaniemi, Sampsa
(Other publication)
Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes (2023)
- Clinical Cancer Research
Pikkusaari Sanna, Tumiati Manuela, Virtanen Anni, Oikkonen Jaana, Li Yilin, Perez-Villatoro Fernando, Muranen Taru, Salko Matilda, Huhtinen Kaisa, Kanerva Anna, Koskela Heidi, Tapper Johanna, Koivisto-Korander Riitta, Joutsiniemi Titta, Haltia Ulla-Maija, Lassus Heini, Hautaniemi Sampsa, Färkkilä Anniina, Hynninen Johanna, Hietanen Sakari, Carpen Olli, Kauppi Liisa
(A1 Refereed original research article in a scientific journal)
H&E image analysis pipeline for quantifying morphological features (2023)
- Journal of Pathology Informatics
Ariotta Valeria, Lehtonen Oskari, Salloum Shams, Micoli Giulia, Lavikka Kari, Rantanen Ville, Hynninen Johanna, Virtanen Anni, Hautaniemi Sampsa
(A1 Refereed original research article in a scientific journal)
Multi-omics characterization of chemo-refractory high-grade serous cancer (2023)
- International Journal of Gynecological Cancer
Muranen, Taru A.; Afenteva, Daria; Rajavuori, Anna; Jamalzadeh, Sanaz; Zhang, Kaiyang; Ariotta, Valeria; Isoviita, Veli-Matti; Lahtinen, Alexandra; Lavikka, Kari; Lehtonen, Oskari; Li, Yilin; Marchi, Giovanni; Oikkonen, Jaana; Salloum, Shams; Huhtinen, Kaisa; Hietanen, Sakari; Virtanen, Anni; Hynninen, Johanna; Hautaniemi, Sampsa
(Other publication)
Quantification of cell death and proliferation of patient-derived ovarian cancer organoids through 3D imaging and image analysis (2023)
- STAR protocols
Skorda Aikaterini, Lauridsen Anna Rossberg, Huhtinen Kaisa, Lahtinen Alexandra, Senkowski Wojciech, Oikkonen Jaana, Hynninen Johanna, Hautaniemi Sampsa, Kallunki Tuula
(A1 Refereed original research article in a scientific journal)
Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high-grade serous ovarian cancer (2023)
- Basic and Clinical Pharmacology and Toxicology
Deng Feng, Laasik Maren, Salminen Liina, Lapatto Lauri, Huhtinen Kaisa, Li Yilin, Hautaniemi Sampsa, Hynninen Johanna, Niemi Mikko, Lehtonen Rainer
(A1 Refereed original research article in a scientific journal)
A Subset of Secreted Proteins in Ascites Can Predict Platinum-Free Interval in Ovarian Cancer (2022)
- Cancers
Carroll Molly J, Kaipio Katja, Hynninen Johanna, Carpen Olli, Hautaniemi Sampsa, Page David, Kreeger Pamela K
(A1 Refereed original research article in a scientific journal)
Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status (2022)
- Frontiers in Oncology
Roering Pia, Siddiqui Arafat, Heuser Vanina D, Potdar Swapnil, Mikkonen Pia, Oikkonen Jaana, Li Yilin, Pikkusaari Sanna, Wennerberg Krister, Hynninen Johanna, Grenman Seija, Huhtinen Kaisa, Auranen Annika, Carpén Olli, Kaipio Katja
(A1 Refereed original research article in a scientific journal)
Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer (2022)
- Science Advances
Zhang Kaiyang, Erkan Erdogan Pekcan, Jamalzadeh Sanaz, Dai Jun, Andersson Noora, Kaipio Katja, Lamminen Tarja, Mansuri Naziha, Huhtinen Kaisa, Carpén Olli, Hietanen Sakari, Oikkonen Jaana, Hynninen Johanna, Virtanen Anni, Häkkinen Antti, Hautaniemi Sampsa, Vähärautio Anna
(A1 Refereed original research article in a scientific journal)
Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancer (2022)
- npj Precision Oncology
Perez-Villatoro Fernando, Oikkonen Jaana, Casado Julia, Chernenko Anastasiya, Gulhan Doga C., Tumiati Manuela, Li Yilin, Lavikka Kari, Hietanen Sakari, Hynninen Johanna, Haltia Ulla-Maija, Tyrmi Jaakko S., Laivuori Hannele, Konstantinopoulos Panagiotis A., Hautaniemi Sampsa, Kauppi Liisa, Färkkilä Anniina
(A1 Refereed original research article in a scientific journal)
QuantISH: RNA in situ hybridization image analysis framework for quantifying cell type-specific target RNA expression and variability (2022)
- Laboratory Investigation
Jamalzadeh Sanaz, Häkkinen Antti, Andersson Noora, Huhtinen Kaisa, Laury Anna, Hietanen Sakari, Hynninen Johanna, Oikkonen Jaana, Carpén Olli, Virtanen Anni, Hautaniemi Sampsa
(A1 Refereed original research article in a scientific journal)
Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality (2021)
- Scientific Reports
Jukonen Joonas, Moyano-Galceran Lidia, Höpfner Katrin, Pietilä Elina A, Lehtinen Laura, Huhtinen Kaisa, Gucciardo Erica, Hynninen Johanna, Hietanen Sakari, Grénman Seija, Ojala Päivi M, Carpén Olli, Lehti Kaisa
(A1 Refereed original research article in a scientific journal)
Agile Workflow For Interactive Analysis Of Mass Cytometry Data (2021)
- Bioinformatics
Casado J, Lehtonen O, Rantanen V, Kaipio K, Pasquini L, Häkkinen A, Petrucci E, Hynninen J, Hietanen S, Carpén O, Biffoni M, Färkkilä A, Hautaniemi S
(A1 Refereed original research article in a scientific journal)
A Novel Two-Lipid Signature Is a Strong and Independent Prognostic Factor in Ovarian Cancer (2021)
- Cancers
Salminen Liina, Braicu EIena, Lääperi Mitja, Jylhä Antti, Oksa Sinikka, Hietanen Sakari, Sehouli Jalid, Kulbe Hagen, du Bois Andras du, Mahner Sven, Harter Philipp, Carpen Oolli, Huhtinen Kaisa, Hynninen Johanna, Hilvo Mika
(A1 Refereed original research article in a scientific journal)
Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance (2021)
- Nature Communications
Pietilä Elina A., Gonzalez-Molina Jordi, Moyano-Galceran Lidia, Jamalzadeh Sanaz, Zhang Kaiyang, Lehtinen Laura, Turunen S. Pauliina, Martins Tomás A., Gultekin Okan, Lamminen Tarja, Kaipio Katja, Joneborg Ulrika, Hynninen Johanna, Hietanen Sakari, Grénman Seija, Lehtonen Rainer, Hautaniemi Sampsa, Carpén Olli, Carlson Joseph W., Lehti Kaisa
(A1 Refereed original research article in a scientific journal)
Diagnostic efficiency of whole-body 18F-FDG PET/MRI, MRI alone, and SUV and ADC values in staging of primary uterine cervical cancer (2021)
- Cancer Imaging
Steiner Aida, Narva Sara, Rinta-Kiikka Irina, Hietanen Sakari, Hynninen Johanna, Virtanen Johanna
(A1 Refereed original research article in a scientific journal)
FUNGI: Fusion Gene Integration Toolset (2021)
- Bioinformatics
Cervera Alejandra, Rausio Heidi, Kähkönen Tiia, Andersson Noora, Partel Gabriele, Rantanen Ville, Paciello Giulia, Ficarra Elisa, Hynninen Johanna, Hietanen Sakari, Carpén Olli, Lehtonen Rainer, Hautaniemi Sampsa, Huhtinen Kaisa
(A1 Refereed original research article in a scientific journal)
Genetically defined syngeneic mouse models of ovarian cancer as tools for the discovery of combination immunotherapy (2021)
- Cancer Discovery
Iyer Sonia, Zhang Shuang, Yucel Simge, Horn Heiko, Smith Sean G, Reinhardt Ferenc, Hoefsmit Esmee, Assatova Bimarzhan, Casado Julia, Meinsohn Marie-Charlotte, Barrasa M Inmaculada, Bell George W, Perez-Villatoro Fernando, Huhtinen Kaisa, Hynninen Johanna, Oikkonen Jaana, Galhenage Pamoda M, Pathania Shailja, Hammond Paula T, Neel Benjamin G, Färkkilä Anniina, Pépin David, Weinberg Robert A.
(A1 Refereed original research article in a scientific journal)
Imaging of Tumor Hypoxia With F-18-EF5 PET/MRI in Cervical Cancer (2021)
- Clinical Nuclear Medicine
Narva Sara I., Seppänen Marko P., Raiko Juho R. H., Forsback Sarita J., Orte Katri J., Virtanen Johanna M., Hynninen Johanna, Hietanen Sakari
(A1 Refereed original research article in a scientific journal)