Johanna Hynninen
 Adjunct professor, MD, Gynecologic oncologist

  

  

  

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• H&E image analysis pipeline for quantifying morphological features  (2023)  
  • Journal of Pathology Informatics
   Ariotta Valeria, Lehtonen Oskari, Salloum Shams, Micoli Giulia, Lavikka Kari, Rantanen Ville, Hynninen Johanna, Virtanen Anni, Hautaniemi Sampsa

  
  

• Multi-omics characterization of chemo-refractory high-grade serous cancer  (2023)  
  • International Journal of Gynecological Cancer
   Muranen, Taru A.; Afenteva, Daria; Rajavuori, Anna; Jamalzadeh, Sanaz; Zhang, Kaiyang; Ariotta, Valeria; Isoviita, Veli-Matti; Lahtinen, Alexandra; Lavikka, Kari; Lehtonen, Oskari; Li, Yilin; Marchi, Giovanni; Oikkonen, Jaana; Salloum, Shams; Huhtinen, Kaisa; Hietanen, Sakari; Virtanen, Anni; Hynninen, Johanna; Hautaniemi, Sampsa

  
  

• Quantification of cell death and proliferation of patient-derived ovarian cancer organoids through 3D imaging and image analysis  (2023)  
  • STAR protocols
   Skorda Aikaterini, Lauridsen Anna Rossberg, Huhtinen Kaisa, Lahtinen Alexandra, Senkowski Wojciech, Oikkonen Jaana, Hynninen Johanna, Hautaniemi Sampsa, Kallunki Tuula

  
  

• Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high-grade serous ovarian cancer  (2023)  
  • Basic and Clinical Pharmacology and Toxicology
   Deng Feng, Laasik Maren, Salminen Liina, Lapatto Lauri, Huhtinen Kaisa, Li Yilin, Hautaniemi Sampsa, Hynninen Johanna, Niemi Mikko, Lehtonen Rainer

  
  

• A Subset of Secreted Proteins in Ascites Can Predict Platinum-Free Interval in Ovarian Cancer  (2022)  
  • Cancers
   Carroll Molly J, Kaipio Katja, Hynninen Johanna, Carpen Olli, Hautaniemi Sampsa, Page David, Kreeger Pamela K

  
  

• Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status  (2022)  
  • Frontiers in Oncology
   Roering Pia, Siddiqui Arafat, Heuser Vanina D, Potdar Swapnil, Mikkonen Pia, Oikkonen Jaana, Li Yilin, Pikkusaari Sanna, Wennerberg Krister, Hynninen Johanna, Grenman Seija, Huhtinen Kaisa, Auranen Annika, Carpén Olli, Kaipio Katja

  
  

• Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer  (2022)  
  • Science Advances
   Zhang Kaiyang, Erkan Erdogan Pekcan, Jamalzadeh Sanaz, Dai Jun, Andersson Noora, Kaipio Katja, Lamminen Tarja, Mansuri Naziha, Huhtinen Kaisa, Carpén Olli, Hietanen Sakari, Oikkonen Jaana, Hynninen Johanna, Virtanen Anni, Häkkinen Antti, Hautaniemi Sampsa, Vähärautio Anna

  
  

• Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancer  (2022)  
  • npj Precision Oncology
   Perez-Villatoro Fernando, Oikkonen Jaana, Casado Julia, Chernenko Anastasiya, Gulhan Doga C., Tumiati Manuela, Li Yilin, Lavikka Kari, Hietanen Sakari, Hynninen Johanna, Haltia Ulla-Maija, Tyrmi Jaakko S., Laivuori Hannele, Konstantinopoulos Panagiotis A., Hautaniemi Sampsa, Kauppi Liisa, Färkkilä Anniina

  
  

• QuantISH: RNA in situ hybridization image analysis framework for quantifying cell type-specific target RNA expression and variability  (2022)  
  • Laboratory Investigation
   Jamalzadeh Sanaz, Häkkinen Antti, Andersson Noora, Huhtinen Kaisa, Laury Anna, Hietanen Sakari, Hynninen Johanna, Oikkonen Jaana, Carpén Olli, Virtanen Anni, Hautaniemi Sampsa

  
  

• Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality  (2021)  
  • Scientific Reports
   Jukonen Joonas, Moyano-Galceran Lidia, Höpfner Katrin, Pietilä Elina A, Lehtinen Laura, Huhtinen Kaisa, Gucciardo Erica, Hynninen Johanna, Hietanen Sakari, Grénman Seija, Ojala Päivi M, Carpén Olli, Lehti Kaisa