Johanna Hynninen
 Adjunct professor, MD, Gynecologic oncologist

  

  

  

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• Diagnostic efficiency of whole-body 18F-FDG PET/MRI, MRI alone, and SUV and ADC values in staging of primary uterine cervical cancer  (2021)  
  • Cancer Imaging
   Steiner Aida, Narva Sara, Rinta-Kiikka Irina, Hietanen Sakari, Hynninen Johanna, Virtanen Johanna

  
  

• FUNGI: Fusion Gene Integration Toolset  (2021)  
  • Bioinformatics
   Cervera Alejandra, Rausio Heidi, Kähkönen Tiia, Andersson Noora, Partel Gabriele, Rantanen Ville, Paciello Giulia, Ficarra Elisa, Hynninen Johanna, Hietanen Sakari, Carpén Olli, Lehtonen Rainer, Hautaniemi Sampsa, Huhtinen Kaisa

  
  

• Genetically defined syngeneic mouse models of ovarian cancer as tools for the discovery of combination immunotherapy  (2021)  
  • Cancer Discovery
   Iyer Sonia, Zhang Shuang, Yucel Simge, Horn Heiko, Smith Sean G, Reinhardt Ferenc, Hoefsmit Esmee, Assatova Bimarzhan, Casado Julia, Meinsohn Marie-Charlotte, Barrasa M Inmaculada, Bell George W, Perez-Villatoro Fernando, Huhtinen Kaisa, Hynninen Johanna, Oikkonen Jaana, Galhenage Pamoda M, Pathania Shailja, Hammond Paula T, Neel Benjamin G, Färkkilä Anniina, Pépin David, Weinberg Robert A.

  
  

• Imaging of Tumor Hypoxia With F-18-EF5 PET/MRI in Cervical Cancer  (2021)  
  • Clinical Nuclear Medicine
   Narva Sara I., Seppänen Marko P., Raiko Juho R. H., Forsback Sarita J., Orte Katri J., Virtanen Johanna M., Hynninen Johanna, Hietanen Sakari

  
  

• Network-guided identification of cancer-selective combinatorial therapies in ovarian cancer  (2021)  
  • Briefings in Bioinformatics
   He Liye, Bulanova Daria, Oikkonen Jaana, Häkkinen Antti, Zhang Kaiyang, Zheng Shuyu, Wang Wenyu, Erkan Erdogan Pekcan, Carpén Olli, Joutsiniemi Titta, Hietanen Sakari, Hynninen Johanna, Huhtinen Kaisa, Hautaniemi Sampsa, Vähärautio Anna, Tang Jing, Wennerberg Krister, Aittokallio Tero

  
  

• PRISM: Recovering cell type specific expression profiles from individual composite RNA-seq samples  (2021)  
  • Bioinformatics
   Häkkinen Antti, Zhang Kaiyang, Alkodsi Amjad, Andersson Noora, Pekcan Erkan Erdogan, Dai Jun, Kaipio Katja, Lamminen Tarja, Mansuri Naziha, Huhtinen Kaisa, Vähärautio Anna, Carpén Olli, Hynninen Johanna, Hietanen Sakari, Lehtonen Rainer, Hautaniemi Sampsa

  
  

• Syöpäsolujen lääkeresistenssi ja miten se voitetaan - valokeilassa munasarjasyöpä  (2021)  
  • Duodecim
   Hautaniemi Sampsa, Hynninen Johanna

  
  

• ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors  (2020)  
  • Journal of Pathology
   Katja Kaipio, Ping Chen, Pia Roering, Kaisa Huhtinen, Piia Mikkonen, Päivi Östling, Laura Lehtinen, Naziha Mansuri, Taina Korpela, Swapnil Potdar, Johanna Hynninen, Annika Auranen, Seija Grénman, Krister Wennerberg, Sampsa Hautaniemi, Olli Carpén

  
  

• A longitudinal analysis of CA125 glycoforms in the monitoring and follow up of high grade serous ovarian cancer  (2020)  
  • Gynecologic Oncology
   Liina Salminen, Nimrah Nadeem, Shruti Jain, Seija Grènman, Olli Carpén, Sakari Hietanen, Sinikka Oksa, Urpo Lamminmäki, Kim Pettersson, Kamlesh Gidwani, Kaisa Huhtinen, Johanna Hynninen

  
  

• American Association for Cancer Research Special Conference on Advances in Ovarian Cancer Research Sep 13-16, 2019 Atlanta, GA, USA Abstracts  (2020)  
  • Clinical Cancer Research
   Oikkonen J, Sanz NC, Hakkinen A, Li YL, Schulman I, Kivikoski M, Huhtinen K, Hietanen S, Grenman SE, Hynninen J, Lehtonen R, Hautaniemi S

  
  

• Analysis of single-cell RNA-seq data from ovarian cancer samples before and after chemotherapy links stress-related transcriptional profile with chemotherapy resistance  (2020)  
  • bioRxiv
   Zhang K, Erkan EP, Dai J, Andersson N, Kaipio K, Lamminen T, Mansuri N, Huhtinen K, Carpen O, Hynninen J, others

  
  

• Author Correction: Virtual clinical trials identify effective combination therapies in ovarian cancer  (2020)  
  • Scientific Reports
   Kozłowska E, Vallius T, Hynninen J, Hietanen S, Färkkilä A, Hautaniemi S

  
  

• Exploratory Analysis of CA125-MGL and –STn Glycoforms in the Differential Diagnostics of Pelvic Masses  (2020)  
  • The Journal of Applied Laboratory Medicine
   Liina Salminen, Nimrah Nadeem, Anne Lone Rolfsen, Anne Dørum, Teemu D Laajala, Seija Grènman, Sakari Hietanen, Taija Heinosalo, Antti Perheentupa, Matti Poutanen, Nils Bolstad, Olli Carpén, Urpo Lamminmäki, Kim Pettersson, Kamlesh Gidwani, Johanna Hynninen, Kaisa Huhtinen

  
  

• Extracellular matrix proteins increase invasive growth and chemotherapy resistance of ovarian cancer cells  (2020)  
  • Clinical Cancer Research
   Pietila EA, Gonzales-Molina J, Moyano-Galceran L, Lehtinen L, Turunen P, Martins TS, Rantanen V, Hakkinen A, Jamalzadeh S, Zhang KY, Lamminen T, Kaipio K, Hynninen J, Hietanen S, Grenman S, Lehtonen R, Hautaniemi S, Carpen O, Lehti K, Lehti K

  
  

• Glycovariant-based lateral flow immunoassay to detect ovarian cancer–associated serum CA125  (2020)  
  • Communications Biology
   Sherif Bayoumy, Heidi Hyytiä, Janne Leivo, Sheikh M. Talha, Kaisa Huhtinen, Matti Poutanen, Johanna Hynninen, Antti Perheentupa, Urpo Lamminmäki, Kamlesh Gidwani & Kim Pettersson

  
  

• HE4 in the evaluation of tumor load and prognostic stratification of high grade serous ovarian carcinoma  (2020)  
  • Acta Oncologica
   Liina Salminen, Kamlesh Gidwani, Seija Grènman, Olli Carpén, Sakari Hietanen, Kim Pettersson, Kaisa Huhtinen, Johanna Hynninen

  
  

• qSNE: quadratic rate t-SNE optimizer with automatic parameter tuning for large datasets  (2020)  
  • Bioinformatics
   Häkkinen A, Koiranen J, Casado J, Kaipio K, Lehtonen O, Petrucci E, Hynninen J, Hietanen S, Carpén O, Pasquini L, Biffoni M, Lehtonen R, Hautaniemi S

  
  

• RNA-seq analysis of high-grade serous ovarian cancer patients before and after chemotherapy reveals chemoresistance-associated genes and pathways  (2020)  
  • Clinical Cancer Research
   Jamalzadeh S, Zhang KY, Hakkinen A, Huhtinen K, Hynninen J, Andersson N, Mansuri N, Carpen O, Erdogan E, Dai J, Vaharautio A, Hietanen S, Oikkonen J, Lehtonen R, Hautaniemi S

  
  

• Singling out tumor heterogeneity and chemoresistance in high-grade serous ovarian cancer  (2020)  
  • Clinical Cancer Research
   Erkan EP, Dai J, Zhang KY, Kaipio K, Lamminen T, Mansuri N, Suominen L, Alkodsi A, Huhtinen K, Hietanen S, Hynninen J, Grenman S, Carpen O, Hautaniemi S, Vaharautio A

  
  

• The feasibility of [F-18]EF5-PET/CT to image hypoxia in ovarian tumors: a clinical study  (2020)  
  • EJNMMI Research
   Maren Laasik, Johanna Hynninen, Sarita Forsback, Tommi Noponen, Marko Seppänen, Sakari Hietanen