Laura Elo
laura.elo@utu.fi +358 29 450 2090 +358 50 468 0795 Tykistökatu 6 Turku ORCID-tunniste: https://orcid.org/0000-0001-5648-4532 |
Computational biomedicine, medical bioinformatics, data science, machine learning, artificial intelligence, biomarkers, computational systems immunology
Laura Elo is Professor of Computational Medicine and Head of Medical Bioinformatics Centre at University of Turku, Finland. She received PhD in Applied Mathematics in 2007 and became Adjunct Professor in Biomathematics in 2011. After postdoctoral research in molecular immunology and computational systems biology, she received JDRF Career Development Award from US and established herself as independent group leader. In 2014 she became Research Director and in 2016 Vice Director of Turku Bioscience. She has published >180 research articles and >20 software packages and led several research projects (e.g. ERC).
We develop computational methods and models for transforming large-scale molecular and clinical datasets to biomedical knowledge. A specific focus is on analyzing and interpreting data generated by modern high-throughput biotechnologies and other digital health data in a robust and reproducible manner. Using statistical modelling and advanced machine learning techniques, we have, for instance, identified early markers for type 1 diabetes and developed several powerful computational models for predicting disease and treatment risks. The ultimate goal is to improve the diagnosis, prognosis and treatment of complex diseases in close collaboration with experimental and clinical research groups. In our ongoing studies, we focus on development of robust computational tools for proteome, epigenome, and multi-modal single-cell data analysis; artificial intelligence in the analysis of digital health data for early prediction of disease and treatment risks; and computational systems immunology to study human T cell development and immune-mediated diseases. For more information, visit our website: https://elolab.utu.fi
Modern Biotechnologies and Bioinformatics; Bioinformatics in Drug Discovery; Systems biology; AI in Diagnostics, Drug Discovery and Imaging; Bioinformatics Journal Club
Training of MSc and PhD students and postdoctoral fellows
- Statistical Analysis of Protein microarray Data: a case study in type 1 diabetes research (2014)
- Journal of Proteomics and Bioinformatics
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Statistical detection of quantitative protein biomarkers provides insights into signaling networks deregulated in acute myeloid leukemia (2014)
- Proteomics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A fully scalable online pre-processing algorithm for short oligonucleotide microarray atlases (2013)
- Nucleic Acids Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Analysis of Time-Resolved Gene Expression Measurements across Individuals (2013)
- PLoS ONE
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Optimizing detection of transcription factor-binding sites in ChIP-seq experiments (2013) Deep Sequencing Data Analysis Kallio A, Elo LL
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa) - Transcriptomic Changes Detected Prior to Seroconversion in Children with HLA-Conferred Type 1 Diabetes Susceptibility (2013)
- Scandinavian Journal of Immunology
(O2 Muu julkaisu ) - Melanoma-Associated Cancer-Testis Antigen 16 (CT16) Regulates the Expression of Apoptotic and Antiapoptotic Genes and Promotes Cell Survival (2012)
- PLoS ONE
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Mining proteomic data for biomedical research (2012)
- Wiley Interdisciplinary Reviews: Data Mining and Knowledge Discovery
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Optimizing Detection of Transcription Factor-Binding Sites in ChIP-seq Experiments (2012)
- Nucleic Acids Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Probabilistic Analysis of Probe Reliability in Differential Gene Expression Studies with Short Oligonucleotide Arrays (2011)
- IEEE/ACM Transactions on Computational Biology and Bioinformatics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling (2010)
- Journal of Autoimmunity
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Genetic Variants and Their Interactions in the Prediction of Increased Pre-Clinical Carotid Atherosclerosis: The Cardiovascular Risk in Young Finns Study (2010)
- PLoS Genetics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Genome-wide Profiling of Interleukin-4 and STAT6 Transcription Factor Regulation of Human Th2 Cell Programming (2010)
- Immunity
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Novel Insights Into the Gene Regulatory Networks Regulating Human T Helper (TH) cell Differentiation (2010)
- Scandinavian Journal of Immunology
(O2 Muu julkaisu ) - Quantitative proteomics analysis of the nuclear fraction of human CD4+ cells in the early phases of IL-4-induced Th2 differentiation (2010)
- Molecular and Cellular Proteomics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation (2010)
- Blood
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A practical comparison of methods for detecting transcription factor binding sites in ChIP-seq experiments (2009)
- BMC Genomics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies (2009)
- Genome Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Reproducibility-optimized test statistic for ranking genes in microarray studies (2008)
- IEEE/ACM Transactions on Computational Biology and Bioinformatics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Improving identification of differentially expressed genes by integrative analysis of Affymetrix and Illumina arrays. (2006)
- OMICS
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )