Laura Elo
laura.elo@utu.fi +358 29 450 2090 +358 50 468 0795 Tykistökatu 6 Turku ORCID-tunniste: https://orcid.org/0000-0001-5648-4532 |
Computational biomedicine, medical bioinformatics, data science, machine learning, artificial intelligence, biomarkers, computational systems immunology
Laura Elo is Professor of Computational Medicine and Head of Medical Bioinformatics Centre at University of Turku, Finland. She received PhD in Applied Mathematics in 2007 and became Adjunct Professor in Biomathematics in 2011. After postdoctoral research in molecular immunology and computational systems biology, she received JDRF Career Development Award from US and established herself as independent group leader. In 2014 she became Research Director and in 2016 Vice Director of Turku Bioscience. She has published >180 research articles and >20 software packages and led several research projects (e.g. ERC).
We develop computational methods and models for transforming large-scale molecular and clinical datasets to biomedical knowledge. A specific focus is on analyzing and interpreting data generated by modern high-throughput biotechnologies and other digital health data in a robust and reproducible manner. Using statistical modelling and advanced machine learning techniques, we have, for instance, identified early markers for type 1 diabetes and developed several powerful computational models for predicting disease and treatment risks. The ultimate goal is to improve the diagnosis, prognosis and treatment of complex diseases in close collaboration with experimental and clinical research groups. In our ongoing studies, we focus on development of robust computational tools for proteome, epigenome, and multi-modal single-cell data analysis; artificial intelligence in the analysis of digital health data for early prediction of disease and treatment risks; and computational systems immunology to study human T cell development and immune-mediated diseases. For more information, visit our website: https://elolab.utu.fi
Modern Biotechnologies and Bioinformatics; Bioinformatics in Drug Discovery; Systems biology; AI in Diagnostics, Drug Discovery and Imaging; Bioinformatics Journal Club
Training of MSc and PhD students and postdoctoral fellows
- Riskilaskurimallit tyypillisimmille lyhyen aikavälin komplikaatioille sekä kuolemalle ensivaiheen lonkan kokotekonivelleikkauksen jälkeen perustuen Suomen Endoproteesirekisterin tietokantaan (2021)
- Suomen ortopedia ja traumatologia
(D1 Artikkeli ammattilehdessä) - Secretin activates brown fat and induces satiation (2021)
- Nature Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Stable Iterative Variable Selection (2021)
- Bioinformatics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Vascular Adhesion Protein 1 Mediates Gut Microbial Flagellin-Induced Inflammation, Leukocyte Infiltration, and Hepatic Steatosis (2021)
- Sci
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A carbohydrate-active enzyme (CAZy) profile links successful metabolic specialization of Prevotella to its abundance in gut microbiota (2020)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+T Lymphocyte Signature (2020)
- Frontiers in Immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - CIP2A Constrains Th17 Differentiation by Modulating STAT3 Signaling (2020)
- iScience
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Critical evaluation of the subcutaneous engraftments of hormone naïve primary prostate cancer (2020)
- Translational andrology and urology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Data-Independent Acquisition Mass Spectrometry in Metaproteomics of Gut Microbiota—Implementation and Computational Analysis (2020)
- Journal of Proteome Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Easy-to-use tool for evaluating the elevated acute kidney injury risk against reduced cardiovascular disease risk during intensive blood pressure control (2020)
- Journal of Hypertension
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Histone deacetylases 1 and 2 restrain CD4(+) cytotoxic T lymphocyte differentiation (2020)
- JCI Insight
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Integrative omics approaches provide biological and clinical insights: examples from mitochondrial diseases (2020)
- Journal of Clinical Investigation
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Likelihood contrasts: a machine learning algorithm for binary classification of longitudinal data (2020)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - MASTL promotes cell contractility and motility through kinase-independent signaling (2020)
- Journal of Cell Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Posterior approach, fracture diagnosis, and American Society of Anesthesiology class III-IV are associated with increased risk of revision for dislocation after total hip arthroplasty: An analysis of 33,337 operations from the Finnish Arthroplasty Register (2020)
- Scandinavian Journal of Surgery
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Predicting Skeletal Muscle and Whole-Body Insulin Sensitivity Using NMR-Metabolomic Profiling (2020)
- Journal of the Endocrine Society
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Protein interactome of the Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) in Th17 cells (2020)
- Current Research in Immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Protein synthesis is suppressed in sporadic and familial Parkinson's disease by LRRK2 (2020)
- FASEB Journal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Reproducibility-optimized detection of differential DNA methylation (2020)
- Epigenomics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Transcriptomic responses to hypoxia in endometrial and decidual stromal cells (2020)
- Reproduction
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )