Laura Elo
laura.elo@utu.fi +358 29 450 2090 +358 50 468 0795 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0001-5648-4532 |
Computational biomedicine, medical bioinformatics, data science, machine learning, artificial intelligence, biomarkers, computational systems immunology
Laura Elo is Professor of Computational Medicine and Head of Medical Bioinformatics Centre at University of Turku, Finland. She received PhD in Applied Mathematics in 2007 and became Adjunct Professor in Biomathematics in 2011. After postdoctoral research in molecular immunology and computational systems biology, she received JDRF Career Development Award from US and established herself as independent group leader. In 2014 she became Research Director and in 2016 Vice Director of Turku Bioscience. She has published >180 research articles and >20 software packages and led several research projects (e.g. ERC).
We develop computational methods and models for transforming large-scale molecular and clinical datasets to biomedical knowledge. A specific focus is on analyzing and interpreting data generated by modern high-throughput biotechnologies and other digital health data in a robust and reproducible manner. Using statistical modelling and advanced machine learning techniques, we have, for instance, identified early markers for type 1 diabetes and developed several powerful computational models for predicting disease and treatment risks. The ultimate goal is to improve the diagnosis, prognosis and treatment of complex diseases in close collaboration with experimental and clinical research groups. In our ongoing studies, we focus on development of robust computational tools for proteome, epigenome, and multi-modal single-cell data analysis; artificial intelligence in the analysis of digital health data for early prediction of disease and treatment risks; and computational systems immunology to study human T cell development and immune-mediated diseases. For more information, visit our website: https://elolab.utu.fi
Modern Biotechnologies and Bioinformatics; Bioinformatics in Drug Discovery; Systems biology; AI in Diagnostics, Drug Discovery and Imaging; Bioinformatics Journal Club
Training of MSc and PhD students and postdoctoral fellows
- A fully scalable online pre-processing algorithm for short oligonucleotide microarray atlases (2013)
- Nucleic Acids Research
(A1 Refereed original research article in a scientific journal) - Analysis of Time-Resolved Gene Expression Measurements across Individuals (2013)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Optimizing detection of transcription factor-binding sites in ChIP-seq experiments (2013) Deep Sequencing Data Analysis Kallio A, Elo LL
(A3 Refereed book chapter or chapter in a compilation book) - Transcriptomic Changes Detected Prior to Seroconversion in Children with HLA-Conferred Type 1 Diabetes Susceptibility (2013)
- Scandinavian Journal of Immunology
(Other publication) - Melanoma-Associated Cancer-Testis Antigen 16 (CT16) Regulates the Expression of Apoptotic and Antiapoptotic Genes and Promotes Cell Survival (2012)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Mining proteomic data for biomedical research (2012)
- Wiley Interdisciplinary Reviews: Data Mining and Knowledge Discovery
(A2 Refereed review article in a scientific journal ) - Optimizing Detection of Transcription Factor-Binding Sites in ChIP-seq Experiments (2012)
- Nucleic Acids Research
(A1 Refereed original research article in a scientific journal) - Probabilistic Analysis of Probe Reliability in Differential Gene Expression Studies with Short Oligonucleotide Arrays (2011)
- IEEE/ACM Transactions on Computational Biology and Bioinformatics
(A1 Refereed original research article in a scientific journal) - Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling (2010)
- Journal of Autoimmunity
(A1 Refereed original research article in a scientific journal) - Genetic Variants and Their Interactions in the Prediction of Increased Pre-Clinical Carotid Atherosclerosis: The Cardiovascular Risk in Young Finns Study (2010)
- PLoS Genetics
(A1 Refereed original research article in a scientific journal) - Genome-wide Profiling of Interleukin-4 and STAT6 Transcription Factor Regulation of Human Th2 Cell Programming (2010)
- Immunity
(A1 Refereed original research article in a scientific journal) - Novel Insights Into the Gene Regulatory Networks Regulating Human T Helper (TH) cell Differentiation (2010)
- Scandinavian Journal of Immunology
(Other publication) - Quantitative proteomics analysis of the nuclear fraction of human CD4+ cells in the early phases of IL-4-induced Th2 differentiation (2010)
- Molecular and Cellular Proteomics
(A1 Refereed original research article in a scientific journal) - SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiation (2010)
- Blood
(A1 Refereed original research article in a scientific journal) - A practical comparison of methods for detecting transcription factor binding sites in ChIP-seq experiments (2009)
- BMC Genomics
(A1 Refereed original research article in a scientific journal) - Probe-level estimation improves the detection of differential splicing in Affymetrix exon array studies (2009)
- Genome Biology
(A1 Refereed original research article in a scientific journal) - Reproducibility-optimized test statistic for ranking genes in microarray studies (2008)
- IEEE/ACM Transactions on Computational Biology and Bioinformatics
(A1 Refereed original research article in a scientific journal) - Improving identification of differentially expressed genes by integrative analysis of Affymetrix and Illumina arrays. (2006)
- OMICS
(A1 Refereed original research article in a scientific journal)