Laura Elo
laura.elo@utu.fi +358 29 450 2090 +358 50 468 0795 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0001-5648-4532 |
Computational biomedicine, medical bioinformatics, data science, machine learning, artificial intelligence, biomarkers, computational systems immunology
Laura Elo is Professor of Computational Medicine and Head of Medical Bioinformatics Centre at University of Turku, Finland. She received PhD in Applied Mathematics in 2007 and became Adjunct Professor in Biomathematics in 2011. After postdoctoral research in molecular immunology and computational systems biology, she received JDRF Career Development Award from US and established herself as independent group leader. In 2014 she became Research Director and in 2016 Vice Director of Turku Bioscience. She has published >180 research articles and >20 software packages and led several research projects (e.g. ERC).
We develop computational methods and models for transforming large-scale molecular and clinical datasets to biomedical knowledge. A specific focus is on analyzing and interpreting data generated by modern high-throughput biotechnologies and other digital health data in a robust and reproducible manner. Using statistical modelling and advanced machine learning techniques, we have, for instance, identified early markers for type 1 diabetes and developed several powerful computational models for predicting disease and treatment risks. The ultimate goal is to improve the diagnosis, prognosis and treatment of complex diseases in close collaboration with experimental and clinical research groups. In our ongoing studies, we focus on development of robust computational tools for proteome, epigenome, and multi-modal single-cell data analysis; artificial intelligence in the analysis of digital health data for early prediction of disease and treatment risks; and computational systems immunology to study human T cell development and immune-mediated diseases. For more information, visit our website: https://elolab.utu.fi
Modern Biotechnologies and Bioinformatics; Bioinformatics in Drug Discovery; Systems biology; AI in Diagnostics, Drug Discovery and Imaging; Bioinformatics Journal Club
Training of MSc and PhD students and postdoctoral fellows
- Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes (2018)
- Diabetologia
(A1 Refereed original research article in a scientific journal) - Hydroxysteroid (17 beta) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice (2018)
- FASEB Journal
(A1 Refereed original research article in a scientific journal) - Intratumoral androgen levels are linked to TMPRSS2-ERG fusion in prostate cancer (2018)
- Endocrine-Related Cancer
(A1 Refereed original research article in a scientific journal) - PASI: A novel pathway method to identify delicate group effects (2018)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Phosphonormalizer: an R package for normalization of MS-based label-free phosphoproteomics (2018)
- Bioinformatics
(A1 Refereed original research article in a scientific journal) - Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - SimPhospho: a software tool enabling confident phosphosite assignment (2018)
- Bioinformatics
(A1 Refereed original research article in a scientific journal) - Six-week endurance exercise alters gut metagenome that is not reflected in systemic metabolism in over-weight women (2018)
- Frontiers in Microbiology
(A1 Refereed original research article in a scientific journal) - Tekonivelen sijoiltaanmenoon myötävaikuttavat tekijät lonkan tekonivelleikkauksen jälkeen (2018)
- Suomen ortopedia ja traumatologia
(D1 Article in a professional journal) - Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells (2018)
- Cell Reports
(A1 Refereed original research article in a scientific journal) - Accurate detection of differential expression and splicing using low-level features (2017)
- Methods in Molecular Biology
(A3 Refereed book chapter or chapter in a compilation book) - A DREAM Challenge to build prediction models for short-term discontinuation of docetaxel in metastatic castration-resistant prostate cancer (2017)
- JCO Clinical Cancer Informatics
(B1 Non-refereed article in a scientific journal) - A predictive model of overall survival in patients with metastatic castration-resistant prostate cancer (2017)
- F1000Research
(A1 Refereed original research article in a scientific journal) - Assessing the utilization of radiotherapy near end of life at a Finnish University Hospital: a retrospective cohort study (2017)
- Acta Oncologica
(A1 Refereed original research article in a scientific journal) - Comparison of methods to detect differentially expressed genes between single-cell populations (2017)
- Briefings in Bioinformatics
(A1 Refereed original research article in a scientific journal) - End-of-life chemotherapy use at a Finnish university hospital: a retrospective cohort study. (2017)
- Acta Oncologica
(A1 Refereed original research article in a scientific journal) - Enhanced differential expression statistics for data-independent acquisition proteomics (2017)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma (2017)
- Cancer and Metabolism
(A1 Refereed original research article in a scientific journal) - How Reliable are Trial-based Prognostic Models in Real-world Patients with Metastatic Castration-resistant Prostate Cancer? (2017)
- European Urology
(B1 Non-refereed article in a scientific journal) - Prediction of Adult Dyslipidemia Using Genetic and Childhood Clinical Risk Factors - The Cardiovascular Risk in Young Finns Study (2017)
- Circulation: Cardiovascular Genetics
(A1 Refereed original research article in a scientific journal)