Laura Elo
laura.elo@utu.fi +358 29 450 2090 +358 50 468 0795 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0001-5648-4532 |
Computational biomedicine, medical bioinformatics, data science, machine learning, artificial intelligence, biomarkers, computational systems immunology
Laura Elo is Professor of Computational Medicine and Head of Medical Bioinformatics Centre at University of Turku, Finland. She received PhD in Applied Mathematics in 2007 and became Adjunct Professor in Biomathematics in 2011. After postdoctoral research in molecular immunology and computational systems biology, she received JDRF Career Development Award from US and established herself as independent group leader. In 2014 she became Research Director and in 2016 Vice Director of Turku Bioscience. She has published >180 research articles and >20 software packages and led several research projects (e.g. ERC).
We develop computational methods and models for transforming large-scale molecular and clinical datasets to biomedical knowledge. A specific focus is on analyzing and interpreting data generated by modern high-throughput biotechnologies and other digital health data in a robust and reproducible manner. Using statistical modelling and advanced machine learning techniques, we have, for instance, identified early markers for type 1 diabetes and developed several powerful computational models for predicting disease and treatment risks. The ultimate goal is to improve the diagnosis, prognosis and treatment of complex diseases in close collaboration with experimental and clinical research groups. In our ongoing studies, we focus on development of robust computational tools for proteome, epigenome, and multi-modal single-cell data analysis; artificial intelligence in the analysis of digital health data for early prediction of disease and treatment risks; and computational systems immunology to study human T cell development and immune-mediated diseases. For more information, visit our website: https://elolab.utu.fi
Modern Biotechnologies and Bioinformatics; Bioinformatics in Drug Discovery; Systems biology; AI in Diagnostics, Drug Discovery and Imaging; Bioinformatics Journal Club
Training of MSc and PhD students and postdoctoral fellows
- Tekonivelinfektion riskitekijät ensivaiheen lonkan tekonivelleikkauksen jälkeen (2022)
- Suomen ortopedia ja traumatologia
(D1 Article in a professional journal) - Tool evaluation for the detection of variably sized indels from next generation whole genome and targeted sequencing data (2022)
- PLoS Computational Biology
(A1 Refereed original research article in a scientific journal) - Type 1 Diabetes in Children With Genetic Risk May Be Predicted Very Early With a Blood miRNA (2022)
- Diabetes Care
(B1 Non-refereed article in a scientific journal) - Umbilical cord blood DNA methylation in children who later develop type 1 diabetes (2022)
- Diabetologia
(A1 Refereed original research article in a scientific journal) - Weight Loss Trajectories in Healthy Weight Coaching: Cohort Study (2022)
- JMIR Formative Research
(A1 Refereed original research article in a scientific journal) - A three-feature prediction model for metastasis-free survival after surgery of localized clear cell renal cell carcinoma (2021)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - CIP2A interacts with TopBP1 and drives basal-like breast cancer tumorigenesis (2021)
- Cancer Research
(A1 Refereed original research article in a scientific journal) - Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells (2021)
- Frontiers in Immunology
(A1 Refereed original research article in a scientific journal) - Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer (2021)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Computational deconvolution to estimate cell type-specific gene expression from bulk data (2021)
- NAR Genomics and Bioinformatics: Nucleic Acids Research Genomics and Bioinformatics
(A1 Refereed original research article in a scientific journal) - Computational strategies for single-cell multi-omics integration (2021)
- Computational and Structural Biotechnology Journal
(A1 Refereed original research article in a scientific journal) - Crowdsourcing digital health measures to predict Parkinson's disease severity: the Parkinson's Disease Digital Biomarker DREAM Challenge (2021)
- npj Digital Medicine
(A1 Refereed original research article in a scientific journal) - Differential ATAC-seq and ChIP-seq peak detection using ROTS (2021)
- NAR Genomics and Bioinformatics: Nucleic Acids Research Genomics and Bioinformatics
(A1 Refereed original research article in a scientific journal) - Discovery of a Novel CIP2A Variant (NOCIVA) with Clinical Relevance in Predicting TKI Resistance in Myeloid Leukemias (2021)
- Clinical Cancer Research
(A1 Refereed original research article in a scientific journal) - Evaluation of tools for identifying large copy number variations from ultra-low-coverage whole-genome sequencing data (2021)
- BMC Genomics
(A1 Refereed original research article in a scientific journal) - Exon-level estimates improve the detection of differentially expressed genes in RNA-seq studies (2021)
- RNA Biology
(A1 Refereed original research article in a scientific journal) - ILoReg: a tool for high-resolution cell population identification from single-cell RNA-seq data (2021)
- Bioinformatics
(A1 Refereed original research article in a scientific journal) - Metagenomics analysis of gut microbiota in response to diet intervention and gestational diabetes in overweight and obese women: a randomised, double-blind, placebo-controlled clinical trial (2021)
- Gut
(A1 Refereed original research article in a scientific journal) - Preoperative Risk Prediction Models for Short-Term Revision and Death After Total Hip Arthroplasty : Data from the Finnish Arthroplasty Register (2021)
- JB & JS open access
(A1 Refereed original research article in a scientific journal) - Risk factors for prosthetic joint infections following total hip arthroplasty based on 33,337 hips in the Finnish Arthroplasty Register from 2014 to 2018 (2021)
- Acta Orthopaedica
(A1 Refereed original research article in a scientific journal)