Laura Elo
laura.elo@utu.fi +358 29 450 2090 +358 50 468 0795 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0001-5648-4532(external) |
Computational biomedicine, medical bioinformatics, data science, machine learning, artificial intelligence, biomarkers, computational systems immunology
Laura Elo is Professor of Computational Medicine and Head of Medical Bioinformatics Centre at University of Turku, Finland. She received PhD in Applied Mathematics in 2007 and became Adjunct Professor in Biomathematics in 2011. After postdoctoral research in molecular immunology and computational systems biology, she received JDRF Career Development Award from US and established herself as independent group leader. In 2014 she became Research Director and in 2016 Vice Director of Turku Bioscience. She has published >180 research articles and >20 software packages and led several research projects (e.g. ERC).
We develop computational methods and models for transforming large-scale molecular and clinical datasets to biomedical knowledge. A specific focus is on analyzing and interpreting data generated by modern high-throughput biotechnologies and other digital health data in a robust and reproducible manner. Using statistical modelling and advanced machine learning techniques, we have, for instance, identified early markers for type 1 diabetes and developed several powerful computational models for predicting disease and treatment risks. The ultimate goal is to improve the diagnosis, prognosis and treatment of complex diseases in close collaboration with experimental and clinical research groups. In our ongoing studies, we focus on development of robust computational tools for proteome, epigenome, and multi-modal single-cell data analysis; artificial intelligence in the analysis of digital health data for early prediction of disease and treatment risks; and computational systems immunology to study human T cell development and immune-mediated diseases. For more information, visit our website: https://elolab.utu.fi
Modern Biotechnologies and Bioinformatics; Bioinformatics in Drug Discovery; Systems biology; AI in Diagnostics, Drug Discovery and Imaging; Bioinformatics Journal Club
Training of MSc and PhD students and postdoctoral fellows
- Serum Hydroxysteroid (17beta) dehydrogenase 1 concentration in pregnant women correlates with pregnancy-associated plasma protein a but does not serve as an independent marker for preeclampsia (2024)
- Biology of ReproductionCell Reports
(A1 Refereed original research article in a scientific journal) - Serum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes riskPolymorphism in interferon alpha/beta receptor contributes to glucocorticoid response and outcome of ARDS and COVID-19 (2024)
- iScienceCritical Care
(A1 Refereed original research article in a scientific journal) - A novel easy-to-use index to predict institutionalization and death in older population - a 10-year population-based follow-up study (2023)
- BMC Geriatrics
(A1 Refereed original research article in a scientific journal) - Cell-connectivity-guided trajectory inference from single-cell data (2023)
- Bioinformatics
(A1 Refereed original research article in a scientific journal) - Development and validation of a weight-loss predictor to assist weight loss managementRisk factors for revision due to prosthetic joint infection following total knee arthroplasty based on 62,087 knees in the Finnish Arthroplasty Register from 2014 to 2020 (2023)
- Scientific ReportsActa Orthopaedica
(A1 Refereed original research article in a scientific journal) - Development of prediction model for alanine transaminase elevations during the first 6 months of conventional synthetic DMARD treatment (2023)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Gene expression signature predicts rate of type 1 diabetes progression (2023)
- EBioMedicine
(A1 Refereed original research article in a scientific journal) - PIM kinases regulate early human Th17 cell differentiation (2023)
(A1 Refereed original research article in a scientific journal) - 2023
(A1 Refereed original research article in a scientific journal) - Profiling of peripheral blood B-cell transcriptome in children who developed coeliac disease in a prospective studyAn Unbiased Functional Genetics Screen Identifies Rare Activating ERBB4 Mutations (2023)
- HeliyonCancer Research Communications
(A1 Refereed original research article in a scientific journal) - (2023)
(A1 Refereed original research article in a scientific journal) - Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory (2023)
- Diabetologia
(A1 Refereed original research article in a scientific journal) - VarSCAT: A computational tool for sequence context annotations of genomic variants (2023)
- PLoS Computational BiologyBriefings in Bioinformatics
(A1 Refereed original research article in a scientific journal) - (2022)
- Nutrients
(A1 Refereed original research article in a scientific journal) - (2022)
(A1 Refereed original research article in a scientific journal) - A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation (2022)
- Nucleic Acids ResearchComputational and Structural Biotechnology Journal
(A1 Refereed original research article in a scientific journal) - Benchmarking methods for detecting differential states between conditions from multi-subject single-cell RNA-seq data (2022)
(A1 Refereed original research article in a scientific journal) - Benchmarking tools for detecting longitudinal differential expression in proteomics data allows establishing a robust reproducibility optimization regression approach (2022)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia (2022)
- Reproduction
(A1 Refereed original research article in a scientific journal) - Computational solutions for spatial transcriptomics (2022)
(A2 Refereed review article in a scientific journal )