Nafis Rahman
MD, PhD
nafrah@utu.fi +358 29 450 4637 +358 50 477 3022 Kiinamyllynkatu 10 Turku : C505A |
endocrine-related cancer; gonadotropins; hypothalamus-pituitary-gonadal axis; ardenocortical tumours; novel treatment strategies
Docent of Physiology, University of Turku, Turku, Finland (2005) & Docent of Medicine, Medical University of Bialystok, Poland (2016); Doctor of Medical Sciences (Ph.D.), Medical University of Lodz, Poland (1995); Specialization in Obstetrics & Gynecology, Medical University of Lodz, Poland (1995); Licentiate in Medicine, Medical University of Lodz, Poland (1991)
Working at the University of Turku: from 1996 -
Postdoctoral training: Prof Ilpo Huhtaniemi group 1996 - 1998
Visiting professorships Current: Medical University of Bialystok, Bialystok, Poland; Former: FIU College of Medicine, Miami, FL, USA
Editor in chief from 2016 https://www.journals.elsevier.com/reproductive-biology/
Our study the underlying molecular mechanisms of hormonally regulated cancers (i.e. prostate, ovarian, testicular and adrenocortical), search for their novel biomarkers and treatment. We recently tested the potential of tumor specific zona pellucida antigen-3 immunization to enhance therapeutic effects in several hormonally regulated cancers. We have used successfully conjugated lytic peptides to eradicate only cancer cells through their specific gonadotropin receptors (such as lhcgr). We use transgenic murine endocrine cancer metastatic disease models and immortalized cell lines to test the feasibility of novel treatment strategies starting at cellular, in vivo in TG mice and finally aim for human clinical trials.
Teach at the University of Turku, Faculty of Medicine, medical curriculum students: Physiology, Endocrinology, reproductive Endocrinology; Reproductive Biology courses
Received the teacher of the year award (Vuoden Opettaja) in 2005 from the Student Union & Rector of the University of Turku.
- Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice (2020)
- Cancers
- Nanoparticles carrying fingolimod and methotrexate enables targeted induction of apoptosis and immobilization of invasive thyroid cancer (2020)
- European Journal of Pharmaceutics and Biopharmaceutics
- Cyanidin-3-o-Glucoside Pharmacologically Inhibits Tumorigenesis via Estrogen Receptor β in Melanoma Mice (2019)
- Frontiers in Oncology
- Erratum: Functional Characterization of MicroRNA-27a-3p Expression in Human Polycystic Ovary Syndrome" (Endocrinology (2018) 159:1 (297-309) DOI: 10.1210/en.2017-00219) (2019)
- Endocrinology
- Extragonadal FSHR Expression and Function—Is It Real? (2019)
- Frontiers in Endocrinology
- Features of the fetal gonad in androgen synthesis in the postpubertal testis are preserved in complete androgen insensitivity syndrome due to a novel genetic splice site donor variant in androgen receptor gene intron 1 (2019)
- Journal of Steroid Biochemistry and Molecular Biology
- GnRH antagonist treatment of malignant adrenocortical tumors (2019)
- Endocrine-Related Cancer
- Lipopolysaccharide disrupts gap junctional intercellular communication in an immortalized ovine luteal endothelial cell line (2019)
- Toxicology in Vitro
- Molecular mechanisms underlying mifepristone's agonistic action on ovarian cancer progression (2019)
- EBioMedicine
- Mouse models of adrenal tumors responsive to gonadotropin-releasing hormone and gonadotropins (2019)
- Current Opinion in Endocrine and Metabolic Research
- Constitutively active follicle-stimulating hormone receptor enables androgen-independent spermatogenesis (2018)
- Journal of Clinical Investigation
- Functional Characterization of MicroRNA-27a-3p Expression in Human Polycystic Ovary Syndrome (2018)
- Endocrinology
- Decidualization of the canine uterus: from early until late gestational in vivo morphological observations, and functional characterization of immortalized canine uterine stromal cell lines (2017)
- Reproduction in Domestic Animals
- Functional Consequences of Intracellular Proline Levels Manipulation Affecting PRODH/POX-Dependent Pro-Apoptotic Pathways in a Novel in Vitro Cell Culture Model (2017)
- Cellular Physiology and Biochemistry
- Functional Implications of LH/hCG Receptors in Pregnancy-Induced Cushing Syndrome (2017)
- Journal of the Endocrine Society
- Luteinizing hormone and GATA4 action in the adrenocortical tumorigenesis of gonadectomized female mice (2017)
- Cellular Physiology and Biochemistry
- Novel genes involved in pathophysiology of gonadotropin-dependent adrenal tumors in mice (2017)
- Molecular and Cellular Endocrinology
- Zika virus infection—do they also endanger male fertility? (2017)
- Science China Life Sciences
- Functional Expression of FSH Receptor in Endometriotic Lesions (2016)
- Journal of Clinical Endocrinology and Metabolism
- Revisiting the expression and function of follicle-stimulation hormone receptor in human umbilical vein endothelial cells (2016)
- Scientific Reports