Nafis Rahman
MD, PhD
nafrah@utu.fi +358 29 450 4637 +358 50 477 3022 Kiinamyllynkatu 10 Turku Office: C505A ORCID identifier: https://orcid.org/0000-0001-5257-870X |
endocrine-related cancer; gonadotropins; hypothalamus-pituitary-gonadal axis; ardenocortical tumours; novel treatment strategies
Docent of Physiology, University of Turku, Turku, Finland (2005) & Docent of Medicine, Medical University of Bialystok, Poland (2016); Doctor of Medical Sciences (Ph.D.), Medical University of Lodz, Poland (1995); Specialization in Obstetrics & Gynecology, Medical University of Lodz, Poland (1995); Licentiate in Medicine, Medical University of Lodz, Poland (1991)
Working at the University of Turku: from 1996 -
Postdoctoral training: Prof Ilpo Huhtaniemi group 1996 - 1998
Visiting professorships Current: Medical University of Bialystok, Bialystok, Poland; Former: FIU College of Medicine, Miami, FL, USA
Editor in chief from 2016 https://www.journals.elsevier.com/reproductive-biology/
Our study the underlying molecular mechanisms of hormonally regulated cancers (i.e. prostate, ovarian, testicular and adrenocortical), search for their novel biomarkers and treatment. We recently tested the potential of tumor specific zona pellucida antigen-3 immunization to enhance therapeutic effects in several hormonally regulated cancers. We have used successfully conjugated lytic peptides to eradicate only cancer cells through their specific gonadotropin receptors (such as lhcgr). We use transgenic murine endocrine cancer metastatic disease models and immortalized cell lines to test the feasibility of novel treatment strategies starting at cellular, in vivo in TG mice and finally aim for human clinical trials.
Teach at the University of Turku, Faculty of Medicine, medical curriculum students: Physiology, Endocrinology, reproductive Endocrinology; Reproductive Biology courses
Received the teacher of the year award (Vuoden Opettaja) in 2005 from the Student Union & Rector of the University of Turku.
- Comment on “Atlas of Fshr Expression From Novel Reporter Mice” (2025)
- Endocrinology
(B1 Non-refereed article in a scientific journal) - Hecate-FSHβ33-53C/S lytic peptide conjugate selectively kills targeted follicle stimulating hormone receptor (FSHR)-positive cancer cells (2025)
- Biomedicine and Pharmacotherapy
(A1 Refereed original research article in a scientific journal) - Functional evidence for two distinct mechanisms of action of progesterone and selective progesterone receptor modulator on uterine leiomyomas (2024)
- Fertility and Sterility
(A1 Refereed original research article in a scientific journal) - Novel ectopic expression of zona pellucida 3 glycoprotein in lung cancer promotes tumor growth (2024)
- International Journal of Cancer
(A1 Refereed original research article in a scientific journal) - Progesterone signaling in uterine leiomyoma biology : Implications for potential targeted therapy (2024)
- Advances in Medical Sciences
(A2 Refereed review article in a scientific journal ) - Revisiting the follicle-stimulation hormone receptor expression and function in human myometrium and adipose tissue (2024)
- Molecular Medicine
(A1 Refereed original research article in a scientific journal) - A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer (2023)
- Molecular Cancer
(A1 Refereed original research article in a scientific journal) - A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR (2023)
- Molecular Cancer
(A1 Refereed original research article in a scientific journal) - New Insights on the Progesterone (P4) and PGRMC1/NENF Complex Interactions in Colorectal Cancer Progression (2023)
- Cancers
(A1 Refereed original research article in a scientific journal) - Role and mechanism of miR-335-5p in the pathogenesis and treatment of polycystic ovary syndrome (2023)
- Translational Research
(A1 Refereed original research article in a scientific journal) - The molecular mechanism of miR-96-5p in the pathogenesis and treatment of polycystic ovary syndrome (2023)
- Translational Research
(A1 Refereed original research article in a scientific journal) - Congenital Hypothyroidism and Hyperthyroidism Alters Adrenal Gene Expression, Development, and Function (2022)
- Thyroid
(A1 Refereed original research article in a scientific journal) - Human pluripotent stem cell-derived cells endogenously expressing follicle-stimulating hormone receptors: modeling the function of an inactivating receptor mutation (2022)
- Molecular Human Reproduction
(A1 Refereed original research article in a scientific journal) - Novel Expression of Zona Pellucida 3 Protein in Normal Testis; Potential Functional Implications (2022)
- Molecular and Cellular Endocrinology
(A1 Refereed original research article in a scientific journal) - Follicle-stimulating hormone promotes growth of human prostate cancer cell line-derived tumor xenografts (2021)
- FASEB Journal
(A1 Refereed original research article in a scientific journal) - Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance (2021)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Placenta is Capable of Protecting the Male Fetus from Exposure to Environmental Bisphenol A (2021)
- Exposure and Health
(A1 Refereed original research article in a scientific journal) - Erbb4 regulates the oocyte microenvironment during folliculogenesis (2020)
- Human Molecular Genetics
(A1 Refereed original research article in a scientific journal) - Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension (2020)
- Cardiovascular Research
(A1 Refereed original research article in a scientific journal) - MicroRNA-487a-3p functions as a new tumor suppressor in prostate cancer by targeting CCND1 (2020)
- Journal of Cellular Physiology
(A1 Refereed original research article in a scientific journal)