Nafis Rahman
MD, PhD
nafrah@utu.fi +358 29 450 4637 +358 50 477 3022 Kiinamyllynkatu 10 Turku Office: C505A ORCID identifier: https://orcid.org/0000-0001-5257-870X |
endocrine-related cancer; gonadotropins; hypothalamus-pituitary-gonadal axis; ardenocortical tumours; novel treatment strategies
Docent of Physiology, University of Turku, Turku, Finland (2005) & Docent of Medicine, Medical University of Bialystok, Poland (2016); Doctor of Medical Sciences (Ph.D.), Medical University of Lodz, Poland (1995); Specialization in Obstetrics & Gynecology, Medical University of Lodz, Poland (1995); Licentiate in Medicine, Medical University of Lodz, Poland (1991)
Working at the University of Turku: from 1996 -
Postdoctoral training: Prof Ilpo Huhtaniemi group 1996 - 1998
Visiting professorships Current: Medical University of Bialystok, Bialystok, Poland; Former: FIU College of Medicine, Miami, FL, USA
Editor in chief from 2016 https://www.journals.elsevier.com/reproductive-biology/
Our study the underlying molecular mechanisms of hormonally regulated cancers (i.e. prostate, ovarian, testicular and adrenocortical), search for their novel biomarkers and treatment. We recently tested the potential of tumor specific zona pellucida antigen-3 immunization to enhance therapeutic effects in several hormonally regulated cancers. We have used successfully conjugated lytic peptides to eradicate only cancer cells through their specific gonadotropin receptors (such as lhcgr). We use transgenic murine endocrine cancer metastatic disease models and immortalized cell lines to test the feasibility of novel treatment strategies starting at cellular, in vivo in TG mice and finally aim for human clinical trials.
Teach at the University of Turku, Faculty of Medicine, medical curriculum students: Physiology, Endocrinology, reproductive Endocrinology; Reproductive Biology courses
Received the teacher of the year award (Vuoden Opettaja) in 2005 from the Student Union & Rector of the University of Turku.
- Distinct Testicular Steroidogenic Response Mechanisms Between Neonatal and Adult Heat-Acclimated Male Rats (2015)
- Cellular Physiology and Biochemistry
(A1 Refereed original research article in a scientific journal) - Dysfunction of PSA-specific CD8(+) T cells in prostate cancer patients correlates with CD38 and Tim-3 expression (2015)
- Cancer Immunology, Immunotherapy
(A1 Refereed original research article in a scientific journal) - From the New Editor-in-Chief (2015)
- Reproductive Biology
(B1 Non-refereed article in a scientific journal) - Functional consequences of knocking down porcine prostaglandin synthases in SK-6 swine kidney cell line (2015)
- Reproductive Biology
(A1 Refereed original research article in a scientific journal) - Oestrogen action and male fertility: experimental and clinical findings (2015)
- Cellular and Molecular Life Sciences
(A2 Refereed review article in a scientific journal ) - Estrogen promotes Leydig cell engulfment by macrophages in male infertility (2014)
- Journal of Clinical Investigation
(A1 Refereed original research article in a scientific journal) - International symposium on "Animal models for human health" Preface (2014)
- Reproductive Biology
(B1 Non-refereed article in a scientific journal) - Transgenic mice expressing inhibin alpha-subunit promoter (inh alpha)/Simian Virus 40 T-antigen (Tag) transgene as a model for the therapy of granulosa cell-derived ovarian cancer (2014)
- Reproductive Biology
(A2 Refereed review article in a scientific journal ) - Differential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male rat (2013)
- Journal of Lipid Research
(A1 Refereed original research article in a scientific journal) - Transgenic GATA-4 expression induces adrenocortical tumorigenesis in C57Bl/6 mice (2013)
- Journal of Cell Science
(A1 Refereed original research article in a scientific journal) - Triazine Herbicides and Their Chlorometabolites Alter Steroidogenesis in BLTK1 Murine Leydig Cells (2013)
- Toxicological Sciences
(A1 Refereed original research article in a scientific journal) - A novel treatment strategy for ovarian cancer based on immunization against zona pellucida protein (ZP) 3 (2012)
- FASEB Journal
(A1 Refereed original research article in a scientific journal) - BLTK1 Murine Leydig Cells: A Novel Steroidogenic Model for Evaluating the Effects of Reproductive and Developmental Toxicants (2012)
- Toxicological Sciences
(A1 Refereed original research article in a scientific journal) - Molecular Mechanisms of Bladder Outlet Obstruction in Transgenic Male Mice Overexpressing Aromatase (Cyp19a1) (2011)
- American Journal of Pathology
(A1 Refereed original research article in a scientific journal) - Estrogens and bladder outlet obstruction (2010)
- Journal of Steroid Biochemistry and Molecular Biology
(A2 Refereed review article in a scientific journal ) - Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation (2010)
- Proceedings of the National Academy of Sciences of the United States of America
(A1 Refereed original research article in a scientific journal)