Juha Rinne - UTU Research Portal - UTU Research Portal

Juha Rinne

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Department of Clinical Medicine (Faculty of Medicine)

jurin@utu.fi

+358 50 441 2400

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Progression of Amyloid Accumulation in Late Adulthood Among People With Childhood-Onset Epilepsy (2025)
- Neurology
Joutsa, Juho; Rinne, Juha O.; Niemi, Kalle J.; Karrasch, Mira; Parkkola, Riitta K.; Saunavaara, Jani; Helin, Semi P.; Hermann, Bruce P.; Sillanpää, Matti
Safety and immunogenicity of two Tau-targeting active immunotherapies, ACI-35.030 and JACI-35.054, in participants with early Alzheimer's disease: a phase 1b/2a, multicentre, double-blind, randomised, placebo-controlled study (2025)
- EBioMedicine
Sol, Olivier; Mermoud, Julien; Hallikainen, Merja; Kurl, Sudhir; Rinne, Juha; Dautzenberg, Paul; Vijverberg, Everard G.B.; Mummery, Catherine; Börjesson-Hanson, Anne; Jonsson, Michael; Ritchie, Craig; Pennington, Catherine; Vukicevic, Marija; Gollwitzer, Eva; Fiorini, Emma; Hickman, David T.; Hliva, Valérie; Gray, Julian; Gerasymchuk, Viktoriia; Wagg, Jonathan; Fournier, Nicolas; Lê, Bénédicte; Kezic, Iva; Steukers, Lennert; Triana-Baltzer, Gallen; Theunis, Clara; Streffer, Johannes; Kosco-Vilbois, Marie; Pfeifer, Andrea; Scheltens, Philip
Synaptic Density in Multiple Sclerosis (2025)
- Neurology, Neuroimmunology and Neuroinflammation
Luoma, Amelie; Matilainen, Markus; Tuisku, Jouni Mikael; Aarnio, Richard; Nikkilä, Taru; Laaksonen, Sini; Koivumäki, Mikko; Honkonen, Eveliina; Nylund, Marjo; Wahlroos, Saara; Solin, Olof; Chen, Ming-Kai; Toyonaga, Takuya; Lehto, Jussi; Snellman, Anniina; Rinne, Juha O.; Airas, Laura M.
The protective PLCγ2-P522R variant mitigates Alzheimer’s disease-associated pathologies by enhancing beneficial microglial functions (2025)
- Journal of Neuroinflammation
Takalo, Mari; Jeskanen, Heli; Rolova, Taisia; Kervinen, Inka; Hellén, Marianna; Heikkinen, Sami; Koivisto, Hennariikka; Jokivarsi, Kimmo; Müller, Stephan A.; Koivumäki, Esa-Mikko; Mäkinen, Petra; Juopperi, Sini-Pauliina; Willman, Roosa-Maria; Sinisalo, Rosa; Hoffmann, Dorit; Jäntti, Henna; Peitz, Michael; Fließbach, Klaus; Kuulasmaa, Teemu; Natunen, Teemu; Kemppainen, Susanna; Poutiainen, Pekka; Leinonen, Ville; Malm, Tarja; Martiskainen, Henna; Ramirez, Alfredo; Haapasalo, Annakaisa; Lichtenthaler, Stefan F.; Tanila, Heikki; Haass, Christian; Rinne, Juha; Koistinaho, Jari; Hiltunen, Mikko
Alterations in type 2 dopamine receptors across neuropsychiatric conditions: A large-scale PET cohort (2024)
- NeuroImage: Clinical
Malén T, Santavirta S, De Maeyer S, Tuisku J, Kaasinen V, Kankare T, Isojärvi J, Rinne J, Hietala J, Nuutila P, Nummenmaa L
Alzheimerin taudin lääkehoito (2024) Lääketieteellinen farmakologia ja toksikologia Rinne, Juha; Scheinin, Mika
Alzheimerin tauti sairautena (2024) Lääketieteellinen farmakologia ja toksikologia Rinne, Juha; Scheinin, Mika
Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial (2024)
- Alzheimer's and Dementia
Saadmaan Gazi, Dalmasso Maria Carolina, Ramirez Alfredo, Hiltunen Mikko, Kemppainen Nina, Lehtisalo Jenni, Mangialasche Francesca, Ngandu Tiia, Rinne Juha, Soininen Hilkka, Stephen Ruth, Kivipelto Miia, Solomon Alina
Author Correction: Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial (Nature Medicine, (2023), 29, 6, (1437-1447), 10.1038/s41591-023-02326-3) (2024)
- Nature Medicine
Mummery C.J., Börjesson-Hanson A., Blackburn D.J., Vijverberg E.G.B., De Deyn P.P., Ducharme S., Jonsson M., Schneider A., Rinne J.O., Ludolph A.C., Bodenschatz R., Kordasiewicz H., Swayze E.E., Fitzsimmons B., Mignon L., Moore K.M., Yun C., Baumann T., Li D., Norris D.A., Crean R., Graham D.L., Huang E., Ratti E., Bennett C.F., Junge C., Lane R.M.
Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ε4-enriched cognitively unimpaired elderly (2024)
- Alzheimer's Research and Therapy
Koivumäki Mikko, Ekblad Laura, Lantero-Rodriguez Juan, Ashton Nicholas J., Karikari Thomas K., Helin Semi, Parkkola Riitta, Lötjönen Jyrki, Zetterberg Henrik, Blennow Kaj, Rinne Juha O., Snellman Anniina
Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location (2024)
- Diabetes, Obesity and Metabolism
Ojala, R; Hentilä, J; Lietzén, MS; Arponen, M; Heiskanen, MA; Honkala, SM; Virtanen, H; Koskensalo, K; Lautamäki R; Löyttyniemi, E; Parkkola, R; Heinonen, OJ; Malm, T; Lahti, L; Rinne, J; Eskola, O; Rajander, J; Pietiläinen, KH; Kaprio, J; Ivaska, KK; Hannukainen, JC
Brain amyloid load, subjective memory complaints, and cognitive trajectories in older individuals at risk for dementia (2024)
- European Journal of Neurology
Saadmaan, Gazi; Hall, Anette; Ngandu, Tiia; Kemppainen, Nina; Mangialasche, Francesca; Wittenberg, Gayle M.; Matton, Anna; Rinne, Juha O.; Kivipelto, Miia; Solomon, Alina
Cognitively healthy APOE4/4 carriers show white matter impairment associated with serum NfL and amyloid-PET (2024)
- Neurobiology of Disease
Tato-Fernández Claudia, Ekblad Laura L., Pietilä Elina, Saunavaara Virva, Helin Semi, Parkkola Riitta, Zetterberg Henrik, Blennow Kaj, Rinne Juha O., Snellman Anniina
Correction to: Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA (EJNMMI Research, (2024), 14, 1, (25), 10.1186/s13550-024-01085-7) (2024)
- EJNMMI Research
Alzghool Obada M., Aarnio Richard, Helin Jatta S., Wahlroos Saara, Keller Thomas, Matilainen Markus, Solis Junel, Danon Jonathan J., Kassiou Michael, Snellman Anniina, Solin Olof, Rinne Juha O., Haaparanta‑Solin Merja
Effects of Obesity and Exercise on Hepatic and Pancreatic Lipid Content and Glucose Metabolism : PET Studies in Twins Discordant for BMI (2024)
- Biomolecules
Lietzén, Martin S.; Mari, Andrea; Ojala, Ronja; Hentilä, Jaakko; Koskensalo, Kalle; Lautamäki, Riikka; Löyttyniemi, Eliisa; Parkkola, Riitta; Saunavaara, Virva; Kirjavainen, Anna K.; Rajander, Johan; Malm, Tarja; Lahti, Leo; Rinne, Juha O.; Pietiläinen, Kirsi H.; Iozzo, Patricia; Hannukainen, Jarna C.
Effects of the active amyloid beta immunotherapy CAD106 on PET measurements of amyloid plaque deposition in cognitively unimpaired APOE ε4 homozygotes (2024)
- Alzheimer's and Dementia
Riviere Marie-Emmanuelle, Langbaum Jessica B., Turner R. Scott, Rinne Juha O., Sui Yihan, Cazorla Pilar, Ricart Javier, Meneses Kathleen, Caputo Angelika, Tariot Pierre N., Reiman Eric M., Graf Ana
Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA (2024)
- EJNMMI Research
Alzghool Obada M., Aarnio Richard, Helin Jatta S., Wahlroos Saara, Keller Thomas, Matilainen Markus, Solis Junel, Danon Jonathan J., Kassiou Michael, Snellman Anniina, Solin Olof, Rinne Juha O., Haaparanta-Solin Merja
Kinetic Modeling of Brain [18-F]FDG Positron Emission Tomography Time Activity Curves with Input Function Recovery (IR) Method (2024)
- Metabolites
Bucci, Marco; Rebelos, Eleni; Oikonen, Vesa; Rinne, Juha; Nummenmaa, Lauri; Iozzo, Patricia; Nuutila, Pirjo
Measurement invariance of the Center for Epidemiological Studies-Depression scale and associations with genetic risk in older adults (2024)
- PLoS ONE
Saari, Toni T.; Piirtola, Maarit; Aaltonen, Aino; Palviainen, Teemu; Varjonen, Anni; Julkunen, Valtteri; Rinne, Juha O.; Kaprio, Jaakko; Vuoksimaa, Eero
Midlife insulin resistance, APOE genotype, and change in late-life brain beta-amyloid accumulation : A 5-year follow-up [11C]PIB-PET study (2024)
- Neurobiology of Disease
Pietilä Elina, Snellman Anniina, Tuisku Jouni, Helin Semi, Viitanen Matti, Jula Antti, Rinne Juha O., Ekblad Laura L.