Harry Scheinin
MD
Anesthesiology and Intensive Care harry.scheinin@utu.fi ORCID identifier: https://orcid.org/0000-0002-1171-3511 |
Anesthesiology; Clinical Pharmacology; Neuroscience; Positron Emission Tomography
Harry Scheinin leads the Anesthesia Mechanisms Research Group at the University of Turku, Finland, and has studied the human neurobiology of anesthetic agents for 20 years. He has collaborated with Professor Antti Revonsuo since 2005.
We try to explore the neural correlates of human consciousness using, e.g., modern imaging methods. We aim to separate consciousness from responsiveness, connectedness from disconnection and to compare unconsciousness of physiological sleep with that induced by anesthetic agents. Finding new tools for the distinction of consciousness, connectedness and responsiveness would be groundbreaking and could represent a major leap forward in understanding human consciousness. The results could also help in developing new EEG-based methods to objectively measure consciousness and the depth of general anesthesia.
- Interindividual variability and lateralization of mu-opioid receptors in the human brain (2020)
- NeuroImage
(A1 Refereed original research article in a scientific journal) - Single-subject analysis of N400 event-related potential component with five different methods (2019)
- International Journal of Psychophysiology
(A1 Refereed original research article in a scientific journal) - Suomen Anestesiologiyhdistyksen suositus anestesiatoiminnan järjestämisestä (2019)
- Finnanest
(D1 Article in a professional journal) - The influence of dexmedetomidine and propofol on circulating cytokine levels in healthy subjects (2019)
- BMC Anesthesiology
(A1 Refereed original research article in a scientific journal) - Alterations in heart rate variability in patients with peripheral arterial disease requiring surgical revascularization have limited association with postoperative major adverse cardiovascular and cerebrovascular events (2018)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Comparative effects of dexmedetomidine, propofol, sevoflurane, and S-ketamine on regional cerebral glucose metabolism in humans: a positron emission tomography study (2018)
- British Journal of Anaesthesia
(A1 Refereed original research article in a scientific journal) - Differentiating Drug-related and State-related Effects of Dexmedetomidine and Propofol on the Electroencephalogram (2018)
- Anesthesiology
(A1 Refereed original research article in a scientific journal) - Dreaming and awareness during dexmedetomidine- and propofol-induced unresponsiveness (2018)
- British Journal of Anaesthesia
(A1 Refereed original research article in a scientific journal) - Sleep apnoea is associated with major cardiac events in peripheral arterial disease (vol 43, pg 1652, 2014) (2018)
- European Respiratory Journal
(Other publication) - Spoken words are processed during dexmedetomidine-induced unresponsiveness (2018)
- British Journal of Anaesthesia
(A1 Refereed original research article in a scientific journal) - Using Positron Emission Tomography in Revealing the Mystery of General Anesthesia: Study Design Challenges and Opportunities (2018) Chemical and Biochemical Approaches for the Study of Anesthetic Function Part B Scheinin Harry, Alkire Emilee C., Scheinin Annalotta, Alkire Michael T., Kantonen Oskari, Långsjö Jaakko
(B2 Non-refereed book chapter or chapter in a compilation book) - Inhaled Xenon Attenuates Myocardial Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest The Xe-Hypotheca Trial (2017)
- Journal of the American College of Cardiology
(A1 Refereed original research article in a scientific journal) - Detecting a dexmedetomidine-evoked reduction of noradrenaline release in the human brain with the α2C-adrenoceptor PET ligand [11C]ORM-13070 (2016)
- Synapse
(A1 Refereed original research article in a scientific journal) - Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest A Randomized Clinical Trial (2016)
- JAMA: Journal of the American Medical Association
(A1 Refereed original research article in a scientific journal) - Electroencephalogram reactivity to verbal command after dexmedetomidine, propofol and sevoflurane-induced unresponsiveness (2015)
- Anaesthesia
(A1 Refereed original research article in a scientific journal) - Imaging of a2C-adrenoceptors in the living brain: a method to monitor noradrenaline release? (2015)
- SpringerPlus
(Other publication) - Intravenous ethanol increases dopamine release in the ventral striatum in humans: PET study using bolus-plus-infusion administration of [11C]raclopride (2015)
- Journal of Cerebral Blood Flow and Metabolism
(A1 Refereed original research article in a scientific journal) - Sensitivity of [C-11]ORM-13070 to increased extracellular noradrenaline in the CNS - a PET study in human subjects (2015)
- Psychopharmacology
(A1 Refereed original research article in a scientific journal) - Validation of [11C]ORM-13070 as a PET tracer for alpha2c-adrenoceptors in the human brain (2015)
- Synapse
(A1 Refereed original research article in a scientific journal) - Voiko anestesian syvyyttä mitata aivosähkökäyrällä? (2015)
- Duodecim
(A1 Refereed original research article in a scientific journal)