Urpo Lamminmäki
PhD
urplammi@utu.fi +358 29 450 4587 +358 50 476 5557 Kiinamyllynkatu 10 Turku |
Antibody engineering, Bioaffinity assays, in vitro diagnostics
My research is largely focused to recombinant antibodies and other bioaffinity molecules. I am interested in developing techniques used for tailoring such molecules as well as applications of these molecules in various fields including diagnostics, drug development and biomarker discovery.
Methods and application of molecular biotechnology
Antibody and protein engineering techniques
Protein chemistry
Diagnostics
5 of 5
- Genetically Encoded Protease Substrate Based on Lanthanide-Binding Peptide for Time-Gated Fluorescence Detection (2013)
- Analytical Chemistry
- Identification of a Novel Bacterial Outer Membrane Interleukin-1B-Binding Protein from Aggregatibacter actinomycetemcomitansMultiresidue Detection of Fluoroquinolones: Specificity Engineering of a Recombinant Antibody with Oligonucleotide-Directed Mutagenesis (2013)
- PLoS ONE
- (2013)
- Journal of Agricultural and Food ChemistryJournal of Agricultural and Food Chemistry
- (2013)
- Ecotoxicology and Environmental Safety
- Two ScFv antibody libraries derived from identical VLVH framework with different binding site designs display distinct binding profiles (2013)
- Protein Engineering, Design and SelectionPLoS ONE
- High-performance closed-tube PCR based on switchable luminescence probes (2012)
- Analytica Chimica Acta
- Homogenous M13 bacteriophage quantification assay using switchable lanthanide fluorescence probesDirected antibody-engineering techniques and their applications in food immunoassays2012
- Biotechniques
- Primer Extension Mutagenesis Powered by Selective Rolling Circle Amplification2012
- Cd-specific mutants of mercury-sensing regulatory protein MerR, generated by directed evolution (2011)
- Applied and Environmental MicrobiologyAnalytical Chemistry
- (2011)
- Trends in Analytical Chemistry
- Engineering of a broad-specificity antibody: Detection of eight fluoroquinolone antibiotics simultaneously (2011)
- Analytical BiochemistryMolecular Biotechnology
- Enhanced error-prone RCA mutagenesis by concatemer resolutionImproving broad specificity hapten recognition with protein engineering (2011)
- Plasmid
- Homogeneous detection of avidin based on switchable lanthanide luminescence (2011)
- Analytical Chemistry
- Homogeneous Single-Label Biochemical Ras Activation Assay Using Time-Resolved Luminescence (2011)
- Synthetic single-framework antibody library integrated with rapid affinity maturation by V-L shuffling (2011)
- Protein Engineering, Design and Selection
- Luminescence switching by hybridization-directed mixed lanthanide complex formation (2010)
- Analytical Chemistry
- Oligovalent Fab Display on M13 Phage Improved by Directed Evolution (2010)
- (2002)
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