PhD Urpo Lamminmäki - UTU Research Portal

Urpo Lamminmäki
PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Biotechnology (Department of Life Technologies)

urplammi@utu.fi

+358 29 450 4587

+358 50 476 5557

Kiinamyllynkatu 10

Turku

Antibody engineering, Bioaffinity assays, in vitro diagnostics

My research is largely focused to recombinant antibodies and other bioaffinity molecules. I am interested in developing techniques used for tailoring such molecules as well as applications of these molecules in various fields including diagnostics, drug development and biomarker discovery.

Methods and application of molecular biotechnology
Antibody and protein engineering techniques
Protein chemistry
Diagnostics

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Lectin nanoparticle assays for detecting breast cancer-associated glycovariants of cancer antigen 15-3 (CA15-3) in human plasma (2019)
- PLoS ONE
Joonas Terävä, Leena Tiainen, Urpo Lamminmäki, Pirkko-Liisa Kellokumpu-Lehtinen, Kim Pettersson, Kamlesh Gidwani
Noncompetitive Chromogenic Lateral-Flow Immunoassay for Simultaneous Detection of Microcystins and Nodularin (2019)
- Biosensors
Sultana Akter, Teemu Kustila, Janne Leivo, Gangatharan Muralitharan, Markus Vehniäinen, Urpo Lamminmäki
A cancer-specific detection of serum CA125 improves differential diagnosis of epithelial ovarian cancer from benign conditions. (2018)
- Clinical Cancer Research
Huhtinen K, Gidwani K, Kekki H, Hynninen J, Salminen L, Perheentupa A, Poutanen M, Auranen A, Grenman S, Lamminmaki U, Carpen O, Pettersson K
Array-in-well epitope mapping of phage-displayed antibodies (2018) Epitope Mapping Protocols Urpo Lamminmäki, Gaurav Batra, Petri Saviranta
CA125 glycoform assay improves the performance of conventional CA125 in the diagnostics of epithelial ovarian cancer (2018)
- International Journal of Gynecological Cancer
Salminen L, Gidwani K, Rolfsen AL, Nadeem N, Bolstad N, Dorum A, Grenman S, Hietanen S, Perheentupa A, Poutanen M, Carpen O, Lamminmaki U, Pettersson K, Hynninen J, Huhtinen K
Molecular tools for selective recovery and detection of lignin-derived molecules (2018)
- Green Chemistry
Milla Salmela, Hanna Sanmark, Elena Efimova, Alexander Efimov, Vesa P. Hytönen, Urpo Lamminmäki, Suvi Santala, Ville Santala
Array-in-well binding assay for multiparameter screening of phage displayed antibodies (2017)
- Methods
Susan Pérez-Gamarra, Liisa Hattara, Gaurav Batra, Petri Saviranta, Urpo Lamminmäki
Effect of DNA sequence of Fab fragment on yield characteristics and cell growth of E-coli (2017)
- Scientific Reports
Kulmala A, Huovinen T, Lamminmaki U
Non-competitive ELISA with broad specificity for microcystins and nodularins (2017)
- Advances in Oceanography and Limnology
Sultana Akter, Markus Vehniäinen, Jussi Meriluoto, Lisa Spoof, Urpo Lamminmäki
Rapid and Highly Sensitive Non-Competitive Immunoassay for Specific Detection of Nodularin (2017)
- Microorganisms
Akter S, Vehniainen M, Kankaanpaa HT, Lamminmaki U
Super-sensitive time-resolved fluoroimmunoassay for thyroid-stimulating hormone utilizing europium(III) nanoparticle labels achieved by protein corona stabilization, short binding time, and serum preprocessing. (2017)
- Analytical and Bioanalytical Chemistry
Näreoja T, Rosenholm JM, Lamminmäki U, Hänninen PE
A Nanoparticle-Lectin Immunoassay Improves Discrimination of Serum CA125 from Malignant and Benign Sources (2016)
- Clinical Chemistry
Gidwani Kamlesh, Huhtinen Kaisa, Kekki Henna, van Vliet Sandra, Hynninen Johanna, Koivuviita Niina, Perheentupa Antti, Poutanen Matti, Auranen Annika, Grenman Seija, Lamminmaki Urpo, Carpen Olli, van Kooyk Yvette, Pettersson Kim
Broad-Spectrum Noncompetitive Immunocomplex Immunoassay for Cyanobacterial Peptide Hepatotoxins (Microcystins and Nodularins) (2016)
- Analytical Chemistry
Sultana Akter, Markus Vehniäinen, Lisa Spoof, Sonja Nybom, Jussi Meriluoto, and Urpo Lamminmäki
Casamino acids facilitate the secretion of recombinant dengue virus serotype-3 envelope domain III in Pichia pastoris (2016)
- BMC Biotechnology
Kaushik N, Rohila D, Arora U, Raut R, Lamminmaki U, Khanna N, Batra G
Development of recombinant antibody-based enzyme-linked immunosorbent assay (ELISA) for the detection of skatole (2016)
- Analytical Biochemistry
Janne Leivo, Joonas Mäkela, Jaana Rosenberg, Urpo Lamminmäki
Identification and analysis of anti-HDL scFv-antibodies obtained from phage display based synthetic antibody library – Phage display derived HDL antibodies (2016)
- Clinical Biochemistry
Priyanka Negi,Janita Lövgren,Päivi Malmi,Nina Sirkka,Jari Metso,Tuomas Huovinen,Eeva-Christine Brockmann,Kim Pettersson,Matti Jauhiainen,Urpo Lamminmäki
Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis (2016)
- Science Translational Medicine
Thorek DLJ, Watson PA, Lee SG, Ku AT, Bournazos S, Braun K, Kim K, Sjostrom K, Doran MG, Lamminmaki U, Santos E, Veach D, Turkekul M, Casey E, Lewis JS, Abou DS, van Voss MRH, Scardino PT, Strand SE, Alpaugh ML, Scher HI, Lilja H, Larson SM, Ulmert D
Next generation sequencing of all variable loops of synthetic single framework scFv-Application in anti-HDL antibody selections (2016)
- New Biotechnology
Lovgren J, Pursiheimo JP, Pyykko M, Salmi J, Lamminmaki U
Recombinant antibodies for specific detection of clostridial [Fe-Fe] hydrogenases (2016)
- Scientific Reports
Mangayil R, Karp M, Lamminmaki U, Santala V
Role of lectin microarrays in cancer diagnosis (2016)
- Proteomics
Parvez Syed, Kamlesh Gidwani, Henna Kekki, Janne Leivo, Kim Pettersson, Urpo Lamminmäki