PhD Urpo Lamminmäki - UTU Research Portal

Urpo Lamminmäki
PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Biotechnology (Department of Life Technologies)

urplammi@utu.fi

+358 29 450 4587

+358 50 476 5557

Kiinamyllynkatu 10

Turku

Antibody engineering, Bioaffinity assays, in vitro diagnostics

My research is largely focused to recombinant antibodies and other bioaffinity molecules. I am interested in developing techniques used for tailoring such molecules as well as applications of these molecules in various fields including diagnostics, drug development and biomarker discovery.

Methods and application of molecular biotechnology
Antibody and protein engineering techniques
Protein chemistry
Diagnostics

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A homogeneous assay for rapid detection of cyanobacterial peptide hepatotoxins: Microcystins and nodularins (2019)
- Clinica Chimica Acta
Akter Sultana, Vehniäinen Markus, Lamminmäki Urpo
A Nanoparticle-Based Approach for the Detection of Extracellular Vesicles (2019)
- Scientific Reports
Md. Khirul Islam, Parvez Syed, Laura Lehtinen, Janne Leivo, Kamlesh Gidwani, Saara Wittfooth, Kim Pettersson, Urpo Lamminmäki
Detection of Food Taints and Contaminants Using Novel Engineered Antibodies (2019) Rapid Antibody-based Technologies in Food Analysis Leivo J., Lamminmäki U.
Development of anti-immunocomplex specific antibodies and non-competitive time-resolved fluorescence immunoassay for the detection of estradiol (2019)
- Analytical and Bioanalytical Chemistry
Leivo J., Kivimäki L., Juntunen E., Pettersson K., Lamminmäki U.
Europium Nanoparticle-Based Sialyl-Tn Monoclonal Antibody Discriminates Epithelial Ovarian Cancer-Associated CA125 from Benign Sources (2019)
- The Journal of Applied Laboratory Medicine
Gidwani K, Nadeem N, Huhtinen K, Kekki H, Heinosalo T, Hynninen J, Perheentupa A, Poutanen M, Carpen O, Pettersson K, Lamminmäki U
Improvement of Fab expression by screening combinatorial synonymous signal sequence libraries (2019)
- Microbial Cell Factories
Kulmala A, Huovinen T, Lamminmäki U
Jobitti 2018-2020 – mitä, miksi ja miten? (2019)
- Solubiologi
Wärri A, Koulu M, Lamminmäki U, Mairinoja L, Norström A, Pietilä M, Rainio E, Salminen T, Soini S, Wittfooth S, Strauss L.
Lectin nanoparticle assays for detecting breast cancer-associated glycovariants of cancer antigen 15-3 (CA15-3) in human plasma (2019)
- PLoS ONE
Joonas Terävä, Leena Tiainen, Urpo Lamminmäki, Pirkko-Liisa Kellokumpu-Lehtinen, Kim Pettersson, Kamlesh Gidwani
Noncompetitive Chromogenic Lateral-Flow Immunoassay for Simultaneous Detection of Microcystins and Nodularin (2019)
- Biosensors
Sultana Akter, Teemu Kustila, Janne Leivo, Gangatharan Muralitharan, Markus Vehniäinen, Urpo Lamminmäki
A cancer-specific detection of serum CA125 improves differential diagnosis of epithelial ovarian cancer from benign conditions. (2018)
- Clinical Cancer Research
Huhtinen K, Gidwani K, Kekki H, Hynninen J, Salminen L, Perheentupa A, Poutanen M, Auranen A, Grenman S, Lamminmaki U, Carpen O, Pettersson K
Array-in-well epitope mapping of phage-displayed antibodies (2018) Epitope Mapping Protocols Urpo Lamminmäki, Gaurav Batra, Petri Saviranta
CA125 glycoform assay improves the performance of conventional CA125 in the diagnostics of epithelial ovarian cancer (2018)
- International Journal of Gynecological Cancer
Salminen L, Gidwani K, Rolfsen AL, Nadeem N, Bolstad N, Dorum A, Grenman S, Hietanen S, Perheentupa A, Poutanen M, Carpen O, Lamminmaki U, Pettersson K, Hynninen J, Huhtinen K
Molecular tools for selective recovery and detection of lignin-derived molecules (2018)
- Green Chemistry
Milla Salmela, Hanna Sanmark, Elena Efimova, Alexander Efimov, Vesa P. Hytönen, Urpo Lamminmäki, Suvi Santala, Ville Santala
Array-in-well binding assay for multiparameter screening of phage displayed antibodies (2017)
- Methods
Susan Pérez-Gamarra, Liisa Hattara, Gaurav Batra, Petri Saviranta, Urpo Lamminmäki
Effect of DNA sequence of Fab fragment on yield characteristics and cell growth of E-coli (2017)
- Scientific Reports
Kulmala A, Huovinen T, Lamminmaki U
Non-competitive ELISA with broad specificity for microcystins and nodularins (2017)
- Advances in Oceanography and Limnology
Sultana Akter, Markus Vehniäinen, Jussi Meriluoto, Lisa Spoof, Urpo Lamminmäki
Rapid and Highly Sensitive Non-Competitive Immunoassay for Specific Detection of Nodularin (2017)
- Microorganisms
Akter S, Vehniainen M, Kankaanpaa HT, Lamminmaki U
Super-sensitive time-resolved fluoroimmunoassay for thyroid-stimulating hormone utilizing europium(III) nanoparticle labels achieved by protein corona stabilization, short binding time, and serum preprocessing. (2017)
- Analytical and Bioanalytical Chemistry
Näreoja T, Rosenholm JM, Lamminmäki U, Hänninen PE
A Nanoparticle-Lectin Immunoassay Improves Discrimination of Serum CA125 from Malignant and Benign Sources (2016)
- Clinical Chemistry
Gidwani Kamlesh, Huhtinen Kaisa, Kekki Henna, van Vliet Sandra, Hynninen Johanna, Koivuviita Niina, Perheentupa Antti, Poutanen Matti, Auranen Annika, Grenman Seija, Lamminmaki Urpo, Carpen Olli, van Kooyk Yvette, Pettersson Kim
Broad-Spectrum Noncompetitive Immunocomplex Immunoassay for Cyanobacterial Peptide Hepatotoxins (Microcystins and Nodularins) (2016)
- Analytical Chemistry
Sultana Akter, Markus Vehniäinen, Lisa Spoof, Sonja Nybom, Jussi Meriluoto, and Urpo Lamminmäki