PhD Urpo Lamminmäki - UTU Research Portal

Urpo Lamminmäki
PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Biotechnology (Department of Life Technologies)

urplammi@utu.fi

+358 29 450 4587

+358 50 476 5557

Kiinamyllynkatu 10

Turku

Antibody engineering, Bioaffinity assays, in vitro diagnostics

My research is largely focused to recombinant antibodies and other bioaffinity molecules. I am interested in developing techniques used for tailoring such molecules as well as applications of these molecules in various fields including diagnostics, drug development and biomarker discovery.

Methods and application of molecular biotechnology
Antibody and protein engineering techniques
Protein chemistry
Diagnostics

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Combinatorial mutagenesis with alternative CDR-L1 and-H2 loop lengths contributes to affinity maturation of antibodies (2021)
- New Biotechnology
Brockmann Eeva-Christine, Pyykkö Mikko, Hannula Heidi, Khan Kamran, Lamminmäki Urpo, Huovinen Tuomas
Detection of bladder cancer with aberrantly fucosylated ITGA3 (2021)
- Analytical Biochemistry
Islam Md Khirul, Syed Parvez, Dhondt Bert, Gidwani Kamlesh, Pettersson Kim, Lamminmäki Urpo, Leivo Janne
Development of a Fast SARS-CoV-2 IgG ELISA, Based on Receptor-Binding Domain, and Its Comparative Evaluation Using Temporally Segregated Samples From RT-PCR Positive Individuals (2021)
- Frontiers in Microbiology
Mehdi Farha, Chattopadhyay Souvick, Thiruvengadam Ramachandran, Yadav Sarla, Kumar Manjit, Sinha Sangita Kumari, Goswami Sandeep, Kshetrapal Pallavi, Wadhwa Nitya, Natchu Uma Chandramouli, Sopory Shailaja, Desiraju Bapu Koundinya, Pandey Anil K, Das Asim, Verma Nikhil, Sharma Nandini, Sharma Pragya, Bhartia Vandita, Gosain Mudita, Lodha Rakesh, Lamminmäki Urpo, Shrivastava Tripti, Bhatnagar Shinjini, Batra Gaurav
Humanization, Radiolabeling and Biodistribution Studies of an IgG(1)-Type Antibody Targeting Uncomplexed PSA for Theranostic Applications (2021)
- Pharmaceuticals
Strand Joanna, Sjöström Kjell, Lamminmäki Urpo J, Timmermand Oskar Vilhelmsson, Strand Sven-Erik, Tran Thuy A
Phage Display Selection of an Anti-Idiotype-Antibody with Broad-Specificity to Deoxynivalenol Mycotoxins (2021)
- Toxins
Leivo Janne, Vehniäinen Markus, Lamminmäki Urpo
PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates (2021)
- Clinical Cancer Research
Veach Darren R, Storey Claire M, Lückerath Katharina, Braun Katharina, von Bodman Christian, Lamminmäki Urpo, Kalidindi Teja, Strand Sven-Erik, Strand Joanna, Altai Mohamed, Damoiseaux Robert, Zanzonico Pat, Benabdallah Nadia, Pankov Dmitry, Scher Howard I, Scardino Peter, Larson Steven M, Lilja Hans, McDevitt Michael R, Thorek Daniel LJ, Ulmert David
Three two-site apoA-I immunoassays using phage expressed detector antibodies - Preliminary clinical evaluation with cardiac patients (2021)
- Journal of Pharmaceutical and Biomedical Analysis
Negi Priyanka, Heikkilä Taina, Tallgren Terhi, Malmi Päivi, Lund Juha, Sinisalo Juha, Metso Jari, Jauhiainen Matti, Pettersson Kim, Lamminmäki Urpo, Lövgren Janita
A longitudinal analysis of CA125 glycoforms in the monitoring and follow up of high grade serous ovarian cancer (2020)
- Gynecologic Oncology
Liina Salminen, Nimrah Nadeem, Shruti Jain, Seija Grènman, Olli Carpén, Sakari Hietanen, Sinikka Oksa, Urpo Lamminmäki, Kim Pettersson, Kamlesh Gidwani, Kaisa Huhtinen, Johanna Hynninen
Enhanced cell density cultivation and rapid expression-screening of recombinant Pichia pastoris clones in microscale (2020)
- Scientific Reports
Neha Kaushik, Urpo Lamminmäki, Navin Khanna, Gaurav Batra
Exploratory Analysis of CA125-MGL and –STn Glycoforms in the Differential Diagnostics of Pelvic Masses (2020)
- The Journal of Applied Laboratory Medicine
Liina Salminen, Nimrah Nadeem, Anne Lone Rolfsen, Anne Dørum, Teemu D Laajala, Seija Grènman, Sakari Hietanen, Taija Heinosalo, Antti Perheentupa, Matti Poutanen, Nils Bolstad, Olli Carpén, Urpo Lamminmäki, Kim Pettersson, Kamlesh Gidwani, Johanna Hynninen, Kaisa Huhtinen
Glycovariant-based lateral flow immunoassay to detect ovarian cancer–associated serum CA125 (2020)
- Communications Biology
Sherif Bayoumy, Heidi Hyytiä, Janne Leivo, Sheikh M. Talha, Kaisa Huhtinen, Matti Poutanen, Johanna Hynninen, Antti Perheentupa, Urpo Lamminmäki, Kamlesh Gidwani & Kim Pettersson
Recombinant Antibodies with Unique Specificities Allow for Sensitive and Specific Detection of Uncarboxylated Osteocalcin in Human Circulation (2020)
- Calcified Tissue International
Arponen Milja, Brockmann Eeva-Christine, Kiviranta Riku, Lamminmäki Urpo, Ivaska Kaisa K
Site-Specific Linking of an Oligonucleotide to Mono- and Bivalent Recombinant Antibodies with SpyCatcher-SpyTag System for Immuno-PCR (2020)
- ACS Omega
Anastasiia Kushnarova-Vakal, Antti Äärelä, Tuomas Huovinen, Pasi Virta, Urpo Lamminmäki
A homogeneous assay for rapid detection of cyanobacterial peptide hepatotoxins: Microcystins and nodularins (2019)
- Clinica Chimica Acta
Akter Sultana, Vehniäinen Markus, Lamminmäki Urpo
A Nanoparticle-Based Approach for the Detection of Extracellular Vesicles (2019)
- Scientific Reports
Md. Khirul Islam, Parvez Syed, Laura Lehtinen, Janne Leivo, Kamlesh Gidwani, Saara Wittfooth, Kim Pettersson, Urpo Lamminmäki
Detection of Food Taints and Contaminants Using Novel Engineered Antibodies (2019) Rapid Antibody-based Technologies in Food Analysis Leivo J., Lamminmäki U.
Development of anti-immunocomplex specific antibodies and non-competitive time-resolved fluorescence immunoassay for the detection of estradiol (2019)
- Analytical and Bioanalytical Chemistry
Leivo J., Kivimäki L., Juntunen E., Pettersson K., Lamminmäki U.
Europium Nanoparticle-Based Sialyl-Tn Monoclonal Antibody Discriminates Epithelial Ovarian Cancer-Associated CA125 from Benign Sources (2019)
- The Journal of Applied Laboratory Medicine
Gidwani K, Nadeem N, Huhtinen K, Kekki H, Heinosalo T, Hynninen J, Perheentupa A, Poutanen M, Carpen O, Pettersson K, Lamminmäki U
Improvement of Fab expression by screening combinatorial synonymous signal sequence libraries (2019)
- Microbial Cell Factories
Kulmala A, Huovinen T, Lamminmäki U
Jobitti 2018-2020 – mitä, miksi ja miten? (2019)
- Solubiologi
Wärri A, Koulu M, Lamminmäki U, Mairinoja L, Norström A, Pietilä M, Rainio E, Salminen T, Soini S, Wittfooth S, Strauss L.