Urpo Lamminmäki
PhD
urplammi@utu.fi +358 29 450 4587 +358 50 476 5557 Kiinamyllynkatu 10 Turku |
Antibody engineering, Bioaffinity assays, in vitro diagnostics
My research is largely focused to recombinant antibodies and other bioaffinity molecules. I am interested in developing techniques used for tailoring such molecules as well as applications of these molecules in various fields including diagnostics, drug development and biomarker discovery.
Methods and application of molecular biotechnology
Antibody and protein engineering techniques
Protein chemistry
Diagnostics
- Controlled labelling of tracer antibodies for time-resolved fluorescence-based immunoassays (2024)
- Scientific Reports
- Epitope-specific antibody fragments block aggregation of AGelD187N, an aberrant peptide in gelsolin amyloidosis (2024)
- Journal of Biological Chemistry
- Fully human monoclonal antibody targeting the cysteine-rich substrate-interacting region of ADAM17 on cancer cells (2024)
- Biomedicine and Pharmacotherapy
- Increased stable integration efficiency in CHO cells through enhanced nuclear localization of Bxb1 serine integrase (2024)
- BMC Biotechnology
- Plasma CHI3L1 associates with increased TSPO-PET measurable microglial activation in patients with progressive multiple sclerosis (2024)
- Multiple Sclerosis
- Tetraspanin immunoassay for the detection of extracellular vesicles and renal cell carcinoma (2024)
- Nano select
- Genotyped functional screening of soluble Fab clones enables in-depth analysis of mutation effects (2023)
- Scientific Reports
- ImmunoPET Directed to the Brain: A New Tool for Preclinical and Clinical Neuroscience (2023)
- Biomolecules
- Isolation and functional analysis of phage-displayed antibody fragments targeting the staphylococcal superantigen-like proteins (2023)
- MicrobiologyOpen
- Lectins as potential tools for cancer biomarker discovery from extracellular vesicles (2023)
- Biomarker research
- RECOMBINANT ANTIBODIES AGAINST ANATOXIN: A CYANOBACTERIAL NEUROTOXIN (2023)
- Clinical Chemistry and Laboratory Medicine
- Selection of biophysically favorable antibody variants using a modified Flp-In CHO mammalian display platform (2023)
- Frontiers in Bioengineering and Biotechnology
- Archaic chaperone-usher pili self-secrete into superelastic zigzag springs (2022)
- Nature
- Generation of a Large Repertoire of Monoclonal Antibodies against Dengue Virus NS1 Antigen and the Development of a Novel NS1 Detection Enzyme-Linked Immunosorbent Assay (2022)
- Journal of Immunology
- Integrins are enriched on aberrantly fucosylated tumour‐derived urinary extracellular vesicles (2022)
- Journal of Extracellular Biology
- Isolation and characterization of phage display-derived scFv antibodies against human parechovirus 1 VP0 protein (2022)
- Scientific Reports
- Single-step noncompetitive immunocomplex immunoassay for rapid aflatoxin detection (2022)
- Food Chemistry
- Synonymous Codons and Hydrophobicity Optimization of Post-translational Signal Peptide PelB Increase Phage Display Efficiency of DARPins (2022)
- ACS Synthetic Biology
- Time-resolved fluorescence based direct two-site apoA-I immunoassays and their clinical application in patients with suspected obstructive coronary artery disease (2022)
- Frontiers in Cardiovascular Medicine
- A 15-min non-competitive homogeneous assay for microcystin and nodularin based on time-resolved Förster resonance energy transfer (TR-FRET) (2021)
- Analytical and Bioanalytical Chemistry