PhD Urpo Lamminmäki - UTU Research Portal

Urpo Lamminmäki
PhD

- ,
InFLAMES Flagship (Faculty of Medicine)
- Professor,
Biotechnology (Department of Life Technologies)

urplammi@utu.fi

+358 29 450 4587

+358 50 476 5557

Kiinamyllynkatu 10

Turku

Areas of expertise

Antibody engineering, Bioaffinity assays, in vitro diagnostics

Research

My research is largely focused to recombinant antibodies and other bioaffinity molecules. I am interested in developing techniques used for tailoring such molecules as well as applications of these molecules in various fields including diagnostics, drug development and biomarker discovery.

Teaching

Methods and application of molecular biotechnology
Antibody and protein engineering techniques
Protein chemistry
Diagnostics

Publications

4 of 5

Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis (2016)
- Science Translational Medicine
Thorek DLJ, Watson PA, Lee SG, Ku AT, Bournazos S, Braun K, Kim K, Sjostrom K, Doran MG, Lamminmaki U, Santos E, Veach D, Turkekul M, Casey E, Lewis JS, Abou DS, van Voss MRH, Scardino PT, Strand SE, Alpaugh ML, Scher HI, Lilja H, Larson SM, Ulmert D
(A1 Refereed original research article in a scientific journal)
Next generation sequencing of all variable loops of synthetic single framework scFv-Application in anti-HDL antibody selections (2016)
- New Biotechnology
Lovgren J, Pursiheimo JP, Pyykko M, Salmi J, Lamminmaki U
(A1 Refereed original research article in a scientific journal)
Recombinant antibodies for specific detection of clostridial [Fe-Fe] hydrogenases (2016)
- Scientific Reports
Mangayil R, Karp M, Lamminmaki U, Santala V
(A1 Refereed original research article in a scientific journal)
Role of lectin microarrays in cancer diagnosis (2016)
- Proteomics
Parvez Syed, Kamlesh Gidwani, Henna Kekki, Janne Leivo, Kim Pettersson, Urpo Lamminmäki
(A2 Refereed review article in a scientific journal )
Structural basis for Myf and Psa fimbriae-mediated tropism of pathogenic strains of Yersinia for host tissues (2016)
- Molecular Microbiology
Pakharukova N, Roy S, Tuittila M, Rahman MM, Paavilainen S, Ingars AK, Skaldin M, Lamminmäki U, Härd T, Teneberg S, Zavialov AV.
(A1 Refereed original research article in a scientific journal)
Detection of cyanobacterial sxt genes and paralytic shellfish toxins in freshwater lakes and brackish waters on Åland Islands, Finland (2015)
- Harmful Algae
Henna Savela, Lisa Spoof, Niina Perälä, Mikko Preede, Urpo Lamminmäki, Sonja Nybom, Kerstin Häggqvist, Jussi Meriluoto, Markus Vehniäinen
(A1 Refereed original research article in a scientific journal)
Eph Receptors as Drug Targets: Single-Chain Antibodies and Beyond (2015)
- Current Drug Targets
Lamminmaki U, Nikolov D, Himanen J
(A1 Refereed original research article in a scientific journal)
Fast conversion of scFv to Fab antibodies using type IIs restriction enzymes (2015)
- Journal of Immunological Methods
Sanmark H, Huovinen T, Matikka T, Pettersson T, Lahti M, Lamminmaki U
(A1 Refereed original research article in a scientific journal)
GTP-Specific Fab Fragment-Based GTPase Activity Assay (2015)
- Analytical Chemistry
Kopra K, Rozwandowicz-Jansen A, Syrjanpaa M, Blazevits O, Ligabue A, Veltel S, Lamminmaki U, Abankwa D, Harma H
(A1 Refereed original research article in a scientific journal)
Phage display aided improvement of a unique prostate-specific antigen (PSA) antibody unreactive with Lys(145)-Lys(146) internally cleaved forms (2015)
- Journal of Immunological Methods
Ferdhos Khan Liton, Mari T. Peltola, Markus Vehniäinen, Erica Kuusela, Tiina Pettersson, Urpo Lamminmäki, Kim Pettersson, Eeva-Christine Brockmann
(A1 Refereed original research article in a scientific journal)
Precise construction of oligonucleotide-Fab fragment conjugate for homogeneous immunoassay using HaloTag technology (2015)
- Analytical Biochemistry
Pakkila H, Peltomaa R, Lamminmaki U, Soukka T
(A1 Refereed original research article in a scientific journal)
A homogeneous quenching resonance energy transfer assay for H-Ras activation cycle monitoring and inhibitor screening (2014)
- New Biotechnology
Kari Kopra, Arjan van Aldrichem, Markku Syrjänpää, Stefan Veltel, Pekka Hänninen, Daniel Abankwa, Urpo Lamminmäki, Harri Härmä
(Other publication)
Generation and characterization of a single-chain anti-EphA2 antibody (2014)
- Growth Factors
Goldgur Y, Susi P, Karelehto E, Sanmark H, Lamminmäki U, Oricchio E, Wendel G, Nikolov D, Himanen JP
(A1 Refereed original research article in a scientific journal)
Lactobacillus helveticus MIMLh5-specific antibodies for detection of S-layer protein in Grana Padano protected-designation-of-origin cheese (2014)
- Applied and Environmental Microbiology
Milda Stuknytė, Eeva-Christine Brockmann, Tuomas Huovinen, Simone Guglielmetti, Diego Mora, Valentina Taverniti, Stefania Arioli, Ivano De Noni, Urpo Lamminmäki
(A1 Refereed original research article in a scientific journal)
Rapid quantification of mcyB copy numbers on dry chemistry PCR chips and predictability of microcystin concentrations in freshwater environments (2014)
- Harmful Algae
Henna Savela, Markus Vehniäinen, Lisa Spoof, Sonja Nybom, Jussi Meriluoto, Urpo Lamminmäki
(A1 Refereed original research article in a scientific journal)
The selection performance of an antibody library displayed on filamentous phage coat proteins p9, p3 and truncated p3 (2014)
- BMC Research Notes
Tuomas Huovinen, Markku Syrjänpää, Hanna Sanmark, Titta Seppä, Sultana Akter, Liton Md Ferdhos Khan, Urpo Lamminmäki
(A1 Refereed original research article in a scientific journal)
A simple heterogeneous one-step assay for screening estrogenic compounds (2013)
- Biotechnology Letters
Huovinen T, Rytkonen K, Lamminmaki U, Pellinen T
(A1 Refereed original research article in a scientific journal)
Genetically Encoded Protease Substrate Based on Lanthanide-Binding Peptide for Time-Gated Fluorescence Detection (2013)
- Analytical Chemistry
Vuojola J, Syrjanpaa M, Lamminmaki U, Soukka T
(A1 Refereed original research article in a scientific journal)
Identification of a Novel Bacterial Outer Membrane Interleukin-1B-Binding Protein from Aggregatibacter actinomycetemcomitans (2013)
- PLoS ONE
Paino A, Ahlstrand T, Nuutila J, Navickaite I, Lahti M, Tuominen H, Välimaa H, Lamminmäki U, Pöllänen MT, Ihalin R
(A1 Refereed original research article in a scientific journal)
Multiresidue Detection of Fluoroquinolones: Specificity Engineering of a Recombinant Antibody with Oligonucleotide-Directed Mutagenesis (2013)
- Journal of Agricultural and Food Chemistry
Leivo J, Lamminmäki U, Lövgren T, Vehniäinen M
(A1 Refereed original research article in a scientific journal)