PhD, Adjunct professor (docent) Kaisa Ivaska-Papaioannou - UTU Research Portal

Kaisa Ivaska-Papaioannou
PhD, Adjunct professor (docent)

- Docent,
- University Lecturer
Institute of Biomedicine (Faculty of Medicine)

kaisa.ivaska@utu.fi

+358 29 450 4622

+358 50 407 6533

Kiinamyllynkatu 10

Turku

: C440

: https://orcid.org/0000-0001-7482-7623

bone; bone cell biology; bone metabolism; bone turnover markers; bone marrow adiposity; osteoporosis; diabetes; biomedicine; cell biology

Bone and Energy Metabolism, BoneLab Turku

Senior Lecturer in Cell Biology and Metabolism

Docent in Cell Biology 2012

Bone and energy metabolism

Our reserach group is interested in the crosstalk between bone cells and energy metabolism.

Bone is not only a structural organ but interacts with other cell types in the bone marrow microenvironment and interestingly, also with extra-skeletal cells via bone-derived hormones, osteokines.

Our current research focuses on role of osteokines in local and whole body energy metabolism, and in the interactions between bone-forming osteoblasts and bone marrow adipocytes in the bone microenvironment. We are also interested in the effects of type 2 diabetes on bone cells and bone metabolism. We use cell culture and cell-based methods, in vivo models and patient samples obtained from our clinical collaborators.

Our long term goal is to understand how changes in energy metabolism affect bone cells, bone marrow adipocytes and osteokines in the bone microenvironment.

Group members: Niki Jalava (doctoral researcher), Nicko Widjaja (doctoral researcher), Trine Link (undergraduate student)

Funding: Academy of Finland (2019-24), Laboratoriolääketieteen edistämissäätiö, Turku University Foundation, Diabetes Wellness Finland, Finnish Cultural Foundation

Alumni: Mlja Arponen (PhD 2024), Ronja Ojala (MD PhD 2024), Iida Karhu (MSc 2024), Aapo Alhokankare (MSc 2023), Yimeng Chen (MSc 2022), Sana Rais (MSc 2022), Nicko Widjaja (MSc 2021), Tiina Kähkönen (PhD 2019), Milja Arponen (MSc 2016), Anna-Reetta Virta (MSc 2014)

Cell biology and histology for students in Medicine (first year) and Biomedicine (Bachelor’s Degree Programme). Textbooks Alberts et al. Essential Cell Biology, Young et al. Wheater's Functional Histology.

Laboratory course "Cell and Molecular Biology (laboratory work)" for students in Biomedicine

Laboratory course "Methods in Cell Biology" and for medical students selected for Molecular Medicine Research Track (2-yr programme)

Participating actively in the planning of the curriculum (in particular, first year BSc studies).

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Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes (2018)
- Molecular and Cellular Endocrinology
T. E. Kähkönen, K. K. Ivaska, M. Jian, K. G. Büki, H. K. Väänänen, P. Härkönen
Testicular Function and Bone in Young Men with Severe Childhood-Onset Obesity (2018)
- Hormone Research in Paediatrics
Laakso S, Viljakainen H, Lipsanen-Nyman M, Turpeinen U, Ivaska KK, Anand-Ivell R, Ivell R, Mäkitie O
Changes in bone metabolism after bariatric surgery by gastric bypass or sleeve gastrectomy (2017)
- BONE
Kaisa K Ivaska, Ville Huovinen, Minna Soinio, Jarna C Hannukainen, Virva Saunavaara, Paulina Salminen, Mika Helmiö, Riitta Parkkola, Pirjo Nuutila, Riku Kiviranta
Bone mineral density is increased after a 16-week resistance training intervention in elderly women with decreased muscle strength (2016)
- European Journal of Endocrinology
Huovinen V, Ivaska KK, Kiviranta R, Bucci M, Lipponen H, Sandboge S, Raiko J, Eriksson JG, Parkkola R, Iozzo P, Nuutila P
Obese young adults exhibit lower total and lower free serum 25-hydroxycholecalciferol in a randomized vitamin D intervention (2016)
- Clinical Endocrinology
Holmlund-Suila E, Pekkinen M, Ivaska KK, Andersson S, Mäkitie O, Viljakainen H
Increased Body Adiposity and Serum Leptin Concentrations in Very Long-Term Adult Male Survivors of Childhood Acute Lymphoblastic Leukemia (2015)
- Hormone Research in Paediatrics
Jahnukainen K, Heikkinen R, Henriksson M, Andersson S, Ivaska KK, Puukko-Viertomies LR, Makitie O
The effects of acute hyperinsulinemia on bone metabolism (2015)
- Endocrine Connections
Ivaska KK, Heliövaara MK, Ebeling P, Bucci M, Huovinen V, Väänänen HK, Nuutila P, Koistinen HA
High Adiposity and Serum Leptin Accompanied by Altered Bone Turnover Markers in Severe Juvenile Idiopathic Arthritis. (2014)
- Journal of Rheumatology
Markula-Patjas KP, Ivaska KK, Pekkinen M, Andersson S, Moilanen E, Viljakainen HT, Mäkitie O
Suppressed bone turnover in obesity: a link to energy metabolism? A case-control study (2014)
- Journal of Clinical Endocrinology and Metabolism
Viljakainen H, Ivaska KK, Paldánius P, Lipsanen-Nyman M, Saukkonen T, Pietiläinen KH, Andersson S, Laitinen K, Mäkitie O
The effect of fibroblast growth factor receptor inhibition on the growth of breast cancer cells (2014)
- European Journal of Cancer
Kahkonen TE, Toriseva M, Ivaska KK, Harkonen P
Does The Choice Of Surgical Technique Affect Bone Turnover Changes After Bariatric Surgery? (2013)
- Journal of Bone and Mineral Research
Ivaska K, Soinio M, Hannukainen J, Salminen P, Nuutila P, Kiviranta R
Inactivation of the androgen receptor in bone-forming cells leads to trabecular bone loss in adult female mice (2013)
- BoneKEy Reports
Maatta JA, Buki KG, Ivaska KK, Nieminen-Pihala V, Elo TD, Kahkonen T, Poutanen M, Harkonen P, Vaananen K
Total and Carboxylated Osteocalcin Associate with Insulin Levels in Young Adults Born with Normal or Very Low Birth Weight (2013)
- PLoS ONE
Paldanius PM, Ivaska KK, Hovi P, Andersson S, Eriksson JG, Vaananen K, Kajantie E, Makitie O
Polymorphisms in the inflammatory genes CIITA, CLEC15A and IFNG influence BMD, bone loss and fracture in elderly women (2012)
- PLoS ONE
Swanberg M, McGuigan FE, Ivaska KK, Gerdhem P, Åkesson K
Tactile/kinesthetic stimulation (TKS) increases tibial speed of sound and urinary osteocalcin (U-MidOC and unOC) in premature infants (29-32 weeks PMA) (2012)
- BONE
Haley S, Beachy J, Ivaska KK, Slater H, Smith S, Moyer-Mileur LJ
Urinary osteocalcin and serum pro-C-type natriuretic peptide predict linear catch-up growth in infants (2012)
- Journal of Bone and Mineral Research
Kilpeläinen Leena, Ivaska Kaisa K, Kuiri-Hänninen Tanja, Väänänen H Kalervo, Rehfeld Jens F, Goetze Jens P, Sankilampi Ulla, Dunkel Leo
Bone turnover markers and prediction of fracture: a prospective follow-up study of 1040 elderly women for a mean of nine years (2010)
- Journal of Bone and Mineral Research
Ivaska K K, Gerdhem P, Akesson K, Väänänen H K, Obrant K J
Osteocalcin gene polymorphisms influence concentration of serum osteocalcin and enhance fracture identification (2010)
- Journal of Bone and Mineral Research
McGuigan F, Kumar J, Ivaska K K, Obrant K J, Gerdhem P, Luthman H, Åkesson K
Polymorphisms in the macrophage migration inhibitory factor gene and bone loss in postmenopausal women (2010)
- BONE
Swanberg M, McGuigan F, Ivaska K, Gerdhem P, Lerner U H, Bucala R, Kuchel G, Kenny A, Akesson K
Use of Bone Turnover Markers in Osteoporosis (2010)
- Clinical Reviews in Bone and Mineral Metabolism
Lenora J, Ivaska KK, Gerdhem P