Kaisa Ivaska-Papaioannou
PhD, Adjunct professor (docent)
kaisa.ivaska@utu.fi +358 29 450 4622 +358 50 407 6533 Kiinamyllynkatu 10 Turku Office: C440 ORCID identifier: https://orcid.org/0000-0001-7482-7623 |
bone; bone cell biology; bone metabolism; bone turnover markers; bone marrow adiposity; osteoporosis; diabetes; biomedicine; cell biology
Bone and Energy Metabolism, BoneLab Turku
Senior Lecturer in Cell Biology and Metabolism
Docent in Cell Biology 2012
Bone and energy metabolism
Our reserach group is interested in the crosstalk between bone cells and energy metabolism.
Bone is not only a structural organ but interacts with other cell types in the bone marrow microenvironment and interestingly, also with extra-skeletal cells via bone-derived hormones, osteokines.
Our current research focuses on role of osteokines in local and whole body energy metabolism, and in the interactions between bone-forming osteoblasts and bone marrow adipocytes in the bone microenvironment. We are also interested in the effects of type 2 diabetes on bone cells and bone metabolism. We use cell culture and cell-based methods, in vivo models and patient samples obtained from our clinical collaborators.
Our long term goal is to understand how changes in energy metabolism affect bone cells, bone marrow adipocytes and osteokines in the bone microenvironment.
Group members: Niki Jalava (doctoral researcher), Nicko Widjaja (doctoral researcher), Saana Lauren (undergraduate student)
Funding: Finnish Cultural Foundation, Päivikki and Sakari Sohlberg Foundation
Alumni: Mlja Arponen (PhD 2024), Ronja Ojala (MD PhD 2024), Trine Link (MSc 2026), Iida Karhu (MSc 2024), Aapo Alhokankare (MSc 2023), Yimeng Chen (MSc 2022), Sana Rais (MSc 2022), Nicko Widjaja (MSc 2021), Tiina Kähkönen (PhD 2019), Milja Arponen (MSc 2016), Anna-Reetta Virta (MSc 2014)
PhD theses from the lab: Type 2 diabetes and bone: The interactions between glucose and bone-forming osteoblasts. Milja Arponen, 2024; Effects of exercise training on bone marrow metabolism. Ronja Ojala. 2024.
Cell biology and histology for students in Medicine (first year) and Biomedicine (Bachelor’s Degree Programme). Textbooks Alberts et al. Essential Cell Biology, Young et al. Wheater's Functional Histology.
Laboratory course "Cell and Molecular Biology (laboratory work)" for students in Biomedicine
Laboratory course "Methods in Cell Biology" and for medical students selected for Molecular Medicine Research Track (2-yr programme)
Participating actively in the planning of the curriculum (in particular, first year BSc studies).
- Urinary osteocalcin and serum pro-C-type natriuretic peptide predict linear catch-up growth in infants (2012)
- Journal of Bone and Mineral Research
(A1 Refereed original research article in a scientific journal) - Bone turnover markers and prediction of fracture: a prospective follow-up study of 1040 elderly women for a mean of nine years (2010)
- Journal of Bone and Mineral Research
(A1 Refereed original research article in a scientific journal) - Osteocalcin gene polymorphisms influence concentration of serum osteocalcin and enhance fracture identification (2010)
- Journal of Bone and Mineral Research
(A1 Refereed original research article in a scientific journal) - Polymorphisms in the macrophage migration inhibitory factor gene and bone loss in postmenopausal women (2010)
- BONE
(A1 Refereed original research article in a scientific journal) - Use of Bone Turnover Markers in Osteoporosis (2010)
- Clinical Reviews in Bone and Mineral Metabolism
(A2 Refereed review article in a scientific journal ) - Bone turnover markers are correlated with quantitative ultrasound of the calcaneus: 5-year longitudinal data (2009)
- Osteoporosis International
(A1 Refereed original research article in a scientific journal) - Bone turnover markers are correlated with total skeletal uptake of 99mTc-methylene diphosphonate (99mTc-MDP). (2009)
- BMC Medical Physics
(A1 Refereed original research article in a scientific journal) - Overexpression of cathepsin K accelerates the resorption cycle and osteoblast differentiation in vitro (2009)
- BONE
(A1 Refereed original research article in a scientific journal) - Serial assessment of serum bone metabolism markers identifies women with the highest rate of bone loss and osteoporosis risk (2008)
- Journal of Clinical Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - Urinary osteocalcin and other markers of bone metabolism: the effect of risedronate therapy (2008)
- Scandinavian Journal of Clinical and Laboratory Investigation
(A1 Refereed original research article in a scientific journal)
