Ph.D. dos Jarmo Käpylä - UTU Research Portal

Jarmo Käpylä
Ph.D. dos

- University Lecturer,
Biochemistry (Department of Life Technologies)

jakapy@utu.fi

+358 29 450 4704

+358 40 191 1153

Tykistökatu 6

Turku

ORCID identifier: https://orcid.org/0000-0003-3036-713X

Areas of expertise

Protein structure and function

Research

Extracellular matrix, integrins

Teaching

Lectures: Molecular biology, Proteins

Lab courses: Molecular biology techniques, Protein techniques

Publications

2 of 2

Structure of Collagen Receptor Integrin alpha I-1 Domain Carrying the Activating Mutation E317A (2011)
- Journal of Biological Chemistry
Lahti M, Bligt E, Niskanen H, Parkash V, Brandt AM, Jokinen J, Patrikainen P, Kapyla J, Heino J, Salminen TA
(A1 Refereed original research article in a scientific journal)
The structure of collagen receptor integrin alpha1I domain in active conformation (2011)
- Journal of Biological Chemistry
Matti Lahti, Eva Bligt, Henri Niskanen, Anna Brandt, V Parkash, Johanna Jokinen, Pekka Patrikainen, Jarmo Käpylä, Jyrki Heino, Tiina Salminen
(A1 Refereed original research article in a scientific journal)
A small-molecule inhibitor of integrin alpha 2 beta 1 introduces a new strategy for antithrombotic therapy (2010)
- Thrombosis and Haemostasis
Nissinen L, Pentikainen OT, Jouppila A, Kapyla J, Ojala M, Nieminen J, Lipsanen A, Lappalainen H, Eckes B, Johnson MS, Lassila R, Marjamaki A, Heino J
(A1 Refereed original research article in a scientific journal)
Lumican inhibits cell migration through alpha 2 beta 1 integrin (2010)
- Experimental Cell Research
Zeltz C, Brezillon S, Kapyla J, Eble JA, Bobichon H, Terryn C, Perreau C, Franz CM, Heino J, Maquart FX, Wegrowski Y
(A1 Refereed original research article in a scientific journal)
Molecular mechanism of alpha 2 beta 1 integrin interaction with human echovirus 1 (2010)
- EMBO Journal
Jokinen J, White DJ, Salmela M, Huhtala M, Käpylä J, Sipila K, Puranen JS, Nissinen L, Kankaanpaa P, Marjomaki V, Hyypia T, Johnson MS, Heino J
(A1 Refereed original research article in a scientific journal)
Effects of conformational activation of integrin alpha 1I and alpha 2I domains on selective recognition of laminin and collagen subtypes. – Integrin alpha I domain activation (2008)
- Experimental Cell Research
Tulla M, Lahti M, Puranen JS, Brandt A, Kapyla J, Domogatskaya A, Salminen TA, Tryggvason K, Johnson MS, Heino J
(A1 Refereed original research article in a scientific journal)
Small molecule designed to target metal binding site in the alpha 2I domain inhibits integrin function (2007)
- Journal of Medicinal Chemistry
Kapyla J, Pentikainen OT, Nyronen T, Nissinen L, Lassander S, Jokinen J, Lahti M, Marjamaki A, Johnson MS, Heino J,
(A1 Refereed original research article in a scientific journal)
The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: Structural studies and mechanistic implications (1998) Tuominen V, Heikinheimo P, Kajander T, Torkkel T, Hyytia T, Kapyla J, Lahti R, Cooperman BS, Goldman A
(A1 Refereed original research article in a scientific journal)
Structure and function analysis of Escherichia coli inorganic pyrophosphatase: is a hydroxide ion the key to catalysis? (1995)
- Biochemistry
Salminen T, Käpylä J, Heikinheimo P, Kankare J, Goldman A, Heinonen J, Baykov AA, Cooperman BS, Lahti R.
(A1 Refereed original research article in a scientific journal)