Kaisa Huhtinen
PhD, Adjunct Professor in Cancer Biology
Ovarian cancer; personalized medicine; early diagnostics; prediction; prognosis; biomarker; genomics; drug target; interdicipline research;
- MUC1 and glycan probing of CA19-9 captured biomarkers from cyst fluids and serum provides enhanced recognition of ovarian cancer (2025) Afrin Ruma, Shamima; Vinod, Rufus; Jain, Shruti; Huhtinen, Kaisa; Hynninen, Johanna; Leivo, Janne; Pettersson, Kim; Sundfeldt, Karin; Gidwani, Kamlesh
- Deciphering cancer genomes with GenomeSpy : a grammar-based visualization toolkit (2024) Lavikka, Kari; Oikkonen, Jaana; Li, Yilin; Muranen, Taru; Micoli, Giulia; Marchi, Giovanni; Lahtinen, Alexandra; Huhtinen, Kaisa; Lehtonen, Rainer; Hietanen, Sakari; Hynninen, Johanna; Virtanen, Anni; Hautaniemi, Sampsa
- Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma (2024) Jamalzadeh Sanaz, Dai Jun, Lavikka Kari, Li Yilin, Jiang Jing, Huhtinen Kaisa, Virtanen Anni, Oikkonen Jaana, Hietanen Sakari, Hynninen Johanna, Vähärautio Anna, Häkkinen Antti, Hautaniemi Sampsa
- HRD related signature 3 predicts clinical outcome in advanced tubo-ovarian high-grade serous carcinoma (2024) Koskela Heidi, Li Yilin, Joutsiniemi Titta, Muranen Taru, Isoviita Veli-Matti, Huhtinen Kaisa, Micoli Giulia, Lavikka Kari, Marchi Giovanni, Hietanen Sakari, Virtanen Anni, Hautaniemi Sampsa, Oikkonen Jaana, Hynninen Johanna
- Locus-specific LINE-1 expression in clinical ovarian cancer specimens at the single-cell level (2024) Perkiö Anna, Pradhan Barun, Genc Fatih, Pirttikoski Anna, Pikkusaari Sanna, Erkan Erdogan Pekcan, Falco Matias Marin, Huhtinen Kaisa, Narva Sara, Hynninen Johanna, Kauppi Liisa, Vähärautio Anna
- PIK3R1 fusion drives chemoresistance in ovarian cancer by activating ERK1/2 and inducing rod and ring-like structures (2024) Rausio Heidi, Cervera Alejandra, Heuser Vanina D., West Gun, Oikkonen Jaana, Pianfetti Elena, Lovino Marta, Ficarra Elisa, Taimen Pekka, Hynninen Johanna, Lehtonen Rainer, Hautaniemi Sampsa, Carpén Olli, Huhtinen Kaisa
- Aberrant glycosylation of α3 integrins as diagnostic markers in epithelial ovarian cancer (2023) Jain Shruti, Parimelazhagan Santhi Priyadharshini, Vinod Rufus, Afrin Ruma Shamima, Huhtinen Kaisa, Pettersson Kim, Sundfeldt Karin, Leivo Janne, Gidwani Kamlesh
- A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids (2023) Senkowski Wojciech., Gall-Mas Laura, Falco Matias Marin, Li Yilin, Lavikka Kari, Kriegbaum Mette C., Oikkonen Jaana, Bulanova Daria, Pietras Elin J., Voßgröne Karolin, Chen Yan Jun., Erkan Erdogan Pekcan, Dai Jun, Lundgren Anastasia, Grønning Høg Mia Kristine, Larsen Ida Marie, Lamminen Tarja, Kaipio Katja, Huvila Jutta, Virtanen Anni, Engelholm Lars, Christiansen Pernille, Santoni-Rugiu Eric, Huhtinen Kaisa, Carpén Olli, Hynninen Johanna, Hautaniemi Sampsa, Vähärautio Anna, Wennerberg Krister
- Circulating tumor DNA-based copy-number profiles enable monitoring treatment effects during therapy in high-grade serous carcinoma (2023)
- Biomedicine and Pharmacotherapy
Nguyen Mai TN, Rajavuori Anna, Huhtinen Kaisa, Hietanen Sakari, Hynninen Johanna, Oikkonen Jaana, Hautaniemi Sampsa
- Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma (2023) Lahtinen Alexandra, Lavikka Kari, Virtanen Anni, Li Yilin, Jamalzadeh Sanaz, Skorda Aikaterini, Lauridsen Anna Rössberg, Zhang Kaiynag, Marchi Giovanni, Isoviita Veli-Matti, Ariotta Valeria, Lehtonen Oskari, Muranen Taru A., Huhtinen Kaisa, Carpén Olli, Hietanen Sakari, Senkowski Wojciech, Kallunki Tuula, Häkkinen Aantti, Hynninen Johanna, Oikkonen Jaana, Hautaniemi Sampsa
- Quantification of cell death and proliferation of patient-derived ovarian cancer organoids through 3D imaging and image analysis (2023) Skorda Aikaterini, Lauridsen Anna Rossberg, Huhtinen Kaisa, Lahtinen Alexandra, Senkowski Wojciech, Oikkonen Jaana, Hynninen Johanna, Hautaniemi Sampsa, Kallunki Tuula
- Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high-grade serous ovarian cancer (2023)
- Basic and Clinical Pharmacology and Toxicology
Deng Feng, Laasik Maren, Salminen Liina, Lapatto Lauri, Huhtinen Kaisa, Li Yilin, Hautaniemi Sampsa, Hynninen Johanna, Niemi Mikko, Lehtonen Rainer
- Diagnostic potential of nanoparticle aided assays for MUC16 and MUC1 glycovariants in ovarian cancer (2022)
- International Journal of Cancer
Jain Shruti, Nadeem Nimrah, Ulfenborg Benjamin, Mäkelä Maria, Ruma Shamima Afrin, Terävä Joonas, Huhtinen Kaisa, Leivo Janne, Kristjansdottir Björg, Pettersson Kim, Sundfeldt Karin, Gidwani Kamlesh
- Dubious effects of methadone as an “anticancer” drug on ovarian cancer cell-lines and patient-derived tumor-spheroids (2022) Fiegl Heidelinde, Hagenbuchner Judith, Kyvelidou Christiana, Seeber Beata, Sopper Sieghart, Tsibulak Irina, Wieser Verena, Reiser Elisabeth, Roessler Julia, Huhtinen Kaisa, Carpén Olli, Parson Walther, Sprung Susanne, Marth Christian, Ausserlechner Michael J., Zeimet Alain G.
- Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status (2022) Roering Pia, Siddiqui Arafat, Heuser Vanina D, Potdar Swapnil, Mikkonen Pia, Oikkonen Jaana, Li Yilin, Pikkusaari Sanna, Wennerberg Krister, Hynninen Johanna, Grenman Seija, Huhtinen Kaisa, Auranen Annika, Carpén Olli, Kaipio Katja
- Longitudinal single-cell RNA-seq analysis reveals stress-promoted chemoresistance in metastatic ovarian cancer (2022) Zhang Kaiyang, Erkan Erdogan Pekcan, Jamalzadeh Sanaz, Dai Jun, Andersson Noora, Kaipio Katja, Lamminen Tarja, Mansuri Naziha, Huhtinen Kaisa, Carpén Olli, Hietanen Sakari, Oikkonen Jaana, Hynninen Johanna, Virtanen Anni, Häkkinen Antti, Hautaniemi Sampsa, Vähärautio Anna
- Ovarian Cancers with Low CIP2A Tumor Expression Constitute an APR-246-Sensitive Disease Subtype (2022)
- Molecular Cancer Therapeutics
Cvrljevic Anna N., Butt Umar, Huhtinen Kaisa, Grönroos Tove J., Böckelman Camilla, Lassus Heini, Butzow Ralf, Haglund Caj, Kaipio Katja, Arsiola Tiina, Laajala Teemu D., Connolly Denise C, Ristimäki Ari, Carpen Olli, Pouwels Jeroen, Westermarck Jukka
- QuantISH: RNA in situ hybridization image analysis framework for quantifying cell type-specific target RNA expression and variability (2022) Jamalzadeh Sanaz, Häkkinen Antti, Andersson Noora, Huhtinen Kaisa, Laury Anna, Hietanen Sakari, Hynninen Johanna, Oikkonen Jaana, Carpén Olli, Virtanen Anni, Hautaniemi Sampsa
- Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality (2021) Jukonen Joonas, Moyano-Galceran Lidia, Höpfner Katrin, Pietilä Elina A, Lehtinen Laura, Huhtinen Kaisa, Gucciardo Erica, Hynninen Johanna, Hietanen Sakari, Grénman Seija, Ojala Päivi M, Carpén Olli, Lehti Kaisa
- A Novel Two-Lipid Signature Is a Strong and Independent Prognostic Factor in Ovarian Cancer (2021) Salminen Liina, Braicu EIena, Lääperi Mitja, Jylhä Antti, Oksa Sinikka, Hietanen Sakari, Sehouli Jalid, Kulbe Hagen, du Bois Andras du, Mahner Sven, Harter Philipp, Carpen Oolli, Huhtinen Kaisa, Hynninen Johanna, Hilvo Mika
