Jyrki Heino - UTU Research Portal

Jyrki Heino

- Professor,
Biochemistry (Department of Life Technologies)
- ,
InFLAMES Flagship (Faculty of Medicine)

jyheino@utu.fi

+358 29 450 2197

+358 50 523 8351

Tykistökatu 6

Turku

ORCID identifier: https://orcid.org/0000-0003-2978-805X

Publications

1 of 5

C5aR1 Promotes Invasion, Metastasis, and Poor Prognosis in Cutaneous Squamous Cell Carcinoma (2025)
- American Journal of Pathology
Heiskanen, Lauri; Nissinen, Liisa; Siljamäki, Elina; Knuutila, Jaakko S.; Pellinen, Teijo; Kallajoki, Markku; Heino, Jyrki; Riihilä, Pilvi; Kähäri, Veli-Matti
(A1 Refereed original research article in a scientific journal)
Expression of C1q by Macrophages and Fibroblasts in Tumor Microenvironment Is Associated with Progression and Metastasis of Cutaneous Squamous Cell Carcinoma (2025)
- Journal of Investigative Dermatology
Viiklepp, Kristina; Knuutila, Jaakko S.; Nissinen, Liisa; Siljamäki, Elina; Rappu, Pekka; Suwal, Ujjwal; Pellinen, Teijo; Kallajoki, Markku; Meri, Seppo; Heino, Jyrki; Kähäri, Veli-Matti; Riihilä, Pilvi
(A1 Refereed original research article in a scientific journal)
Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids (2025)
- Nature Protocols
Blondeel, Eva; Ernst, Sam; De Vuyst, Felix; Diosdi, Akos; Pinheiro, Claudio; Estevao, Diogo; Rappu, Pekka; Boiy, Robin; Dedeyne, Sandor; Craciun, Ligia; Goossens, Vera; Dehairs, Jonas; Cruz, Tania; Audenaert, Dominique; Ceelen, Wim; Linnebacher, Michael; Boterberg, Tom; Vandesompele, Jo; Mestdagh, Pieter; Swinnen, Johan; Heino, Jyrki; Horvath, Peter; Oliveira, Maria Jose; Hendrix, An; De Metter, Pieter; De Wever, Olivier
(A1 Refereed original research article in a scientific journal)
Cancer-associated fibroblasts mediate resistance to neoadjuvant therapy in breast cancer (2024)
- Clinical and translational medicine
Xia, Zihan; Vermeulen, Stephanie; Suwal, Ujjwal; Rappu, Pekka; Heino, Jyrki; De Vuyst, Felix; Dedeyne, Sandor; Hendrix, An; Denys, Hannelore; De Wever, Olivier
(B1 Other refereed article (e.g., editorial, letter, comment) in a scientific journal)
Collagen prolyl 4-hydroxylase isoenzymes I and II have sequence specificity towards different X-Pro-Gly triplets (2024)
- Matrix Biology
Salo Antti M., Rappu Pekka, Koski M．Kristian, Karjalainen Emma, Izzi Valerio, Drushinin Kati, Miinalainen Ilkka, Käpylä Jarmo, Heino Jyrki, Myllyharju Johanna
(A1 Refereed original research article in a scientific journal)
Dual-ligand PROTACS mediate superior target protein degradation in vitro and therapeutic efficacy in vivo (2024)
- Chemical Science
Chen, Yong; Xia, Zihan; Suwal, Ujjwal; Rappu, Pekka; Heino, Jyrki; De Wever, Olivier; De Geest, Bruno G.
(A1 Refereed original research article in a scientific journal)
Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality in mice (2024)
- iScience
Talvi Salli, Jokinen Johanna, Sipilä Kalle, Rappu Pekka, Zhang Fu-Ping, Poutanen Matti, Rantakari Pia, Heino Jyrki
(A1 Refereed original research article in a scientific journal)
Pelophen B is a non-taxoid binding microtubule-stabilizing agent with promising preclinical anticancer properties (2024)
- Scientific Reports
Vermeulen, Stephanie; Ernst, Sam; Blondeel, Eva; Xia, Zihan; Rappu, Pekka; Heino, Jyrki; Dedeyne, Sándor; Denys, Hannelore; Sys, Gwen; Gijsels, Stefanie; Depypere, Herman; Tummers, Philippe; Ceelen, Wim; Craciun, Ligia; Demetter, Pieter; Raes, Olivier; Hendrix, An; Van der Eycken, Johan; De Wever, Olivier
(A1 Refereed original research article in a scientific journal)
Protocol to study early lung developmental branching in mouse embryos using explant culture (2024)
- STAR protocols
Talvi, Salli; Jokinen, Johanna; Rantakari, Pia; Heino, Jyrki
(A1 Refereed original research article in a scientific journal)
Inhibition of TGF-β signaling, invasion, and growth of cutaneous squamous cell carcinoma by PLX8394 (2023)
- Oncogene
Siljamäki Elina, Riihilä Pilvi, Suwal Ujjwal, Nissinen Liisa, Rappu Pekka, Kallajoki Markku, Kähäri Veli-Matti, Heino Jyrki
(A1 Refereed original research article in a scientific journal)
Integrins α1β1 and α2β1: The Generalist Collagen Receptors (2023) Integrins in Health and Disease Heino Jyrki, Siljamäki Elina
(A3 Refereed book chapter or chapter in a compilation book)
What does it take to be a collagen receptor? (2023)
- Matrix Biology
Farndale Richard, Sonnenberg Arnoud, DiPersio C Michael, Eble Johannes A, Heino Jyrki, Gullberg Donald
(B1 Non-refereed article in a scientific journal)
C1r Upregulates Production of Matrix Metalloproteinase-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma (2022)
- Journal of Investigative Dermatology
Viiklepp Kristina, Nissinen Liisa, Ojalill Marjaana, Riihilä Pilvi, Kallajoki Markku, Meri Seppo, Heino Jyrki, Kähäri Veli-Matti
(A1 Refereed original research article in a scientific journal)
Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism (2022)
- Developmental Cell
Sipilä Kalle, Rognoni Emanuel, Jokinen Johanna, Tewary Mukul, Rudan Matteo Vietri, Talvi Salli, Jokinen Ville, Dahlström Käthe M, Liakath-Ali Kif, Mobasseri Atefeh, Du-Harpur Xinyi, Käpylä Jarmo, Nutt Stephen L, Salminen Tiina A, Heino Jyrki, Watt Fiona M
(A1 Refereed original research article in a scientific journal)
Inflammation-related citrullination of matrisome proteins in human cancer (2022)
- Frontiers in Oncology
Rappu Pekka, Suwal Ujjwal, Siljamäki Elina, Heino Jyrki
(A1 Refereed original research article in a scientific journal)
Kymmenen vuotta ”toistettavuuskriisiä” (2022)
- InFLAMES Flagship Blog
Heino Jyrki
(E1 Popularised article)
MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity (2021)
- Nature Methods
Peirsman Arne, Blondeel Eva, Ahmed Tasdiq, Anckaert Jasper, Audenaert Dominique, Boterberg Tom, Buzas Krisztina, Carragher Neil, Castellani Gastone, Castro Flavia, Dangles-Marie Virginie, Dawson John, De Tullio Pascal, De Vlieghere Elly, Dedeyne Sándor, Depypere Herman, Diosdi Akos, Dmitriev Ruslan I, Dolznig Helmut, Fischer Suzanne, Gespach Christian, Goossens Vera, Heino Jyrki, Hendrix An, Horvath Peter, Kunz-Schughart Leoni A., Maes Sebastiaan, Mangodt Christophe, Mestdagh Pieter, Michlíková Soña, Oliveira Maria José, Pampaloni Francesco, Piccinini Filippo, Pinheiro Cláudio, Rahn Jennifer, Robbins Stephen M., Siljamaki Elina, Steigemann Patrick, Sys Gwen, Takayama Shuichi, Tesei Anna, Tulkens Joeri, Van Waeyenberge Michiel, Vandesompele Jo, Wagemans Glenn, Weindorfer Claudia, Yigit Nurten, Zablowsky Nina, Zanoni Michele, Blondeel Phillip, De Wever Olivier
(A1 Refereed original research article in a scientific journal)
Feasibility of Mechanical Extrusion to Coat Nanoparticles with Extracellular Vesicle Membranes (2020)
- Cells
Van Deun J, Roux Q, Deville S, Van Acker T, Rappu P, Miinalainen I, Heino J, Vanhaecke F, De Geest BG, De Wever O, Hendrix A
(A1 Refereed original research article in a scientific journal)
H-Ras activation and fibroblast-induced TGF-β signaling promote laminin-332 accumulation and invasion in cutaneous squamous cell carcinoma (2020)
- Matrix Biology
Siljamäki E, Rappu P, Riihilä P, Nissinen L, Kähäri VM, Heino J.
(A1 Refereed original research article in a scientific journal)
Integration of Matrisome Omics: Towards System Biology of the Tumor Matrisome (2020) Extracellular Matrix Omics Valerio Izzi, Jarkko Koivunen, Pekka Rappu, Jyrki Heino, Taina Pihlajaniemi
(A3 Refereed book chapter or chapter in a compilation book)