Klaus Elenius
MD, PhD, professor
ACTIONABLE RECEPTOR TYROSINE KINASE SIGNALING
Our goal is to understand how receptor tyrosine kinases (RTK) regulate the pathogenesis of human diseases, such as cancer. This information is needed for the development of molecularly targeted therapies. To recognize aberrations of RTK signaling in diseased tissue our laboratory also works on the molecular mechanism by which RTKs control normal processes, such as embryonic development. The work mainly focuses on the ErbB family of RTKs. Our laboratory has contributed to the field by e.g. by characterizing novel RTK signaling mechanisms, by identifying novel ErbB4 isoforms, and by determining the role of ErbBs and their ligands in angiogenesis.
Current topics
- Screens for predictive RTK mutations
- Novel RTK signaling mechanisms
- Development of preclinical models for development novel RTK inhibitors
- Sequencing of RTK inhibitor drug administration with cytotoxic agents
- In vitro “basket trials” with ErbB inhibitor drugs
- RTK signaling in angiogenesis and cardiovascular diseases
- RTKs in pediatric malignancies
- Biological role of novel ErbB4 isoforms in diseases and development
Elenius Lab members
- Anne Jokilammi, PhD
- Elli Narvi, PhD
- Deepankar Chakroborty, MSc
- Juho Heliste, MD
- Marika Koivu, MSc
- Johannes Merilahti, MSc
- Veera Ojala, MSc
- Janne Nordberg, MD
- Fred Saarinen, MSc
- Katri Vaparanta, MSc
- Kaisa Aalto, BM
- Maria Helkkula, BM
- Matias Mäenpää, BM
- Peppi Kirjalainen, BM
- Jori Torkkila, BM
- Gamma-secretase-dependent signaling of receptor tyrosine kinases (2019) Merilahti JAM, Elenius K
- Genetic architecture of human plasma lipidome and its link to cardiovascular disease (2019) Tabassum R, Ramo JT, Ripatti P, Koskela JT, Kurki M, Karjalainen J, Palta P, Hassan S, Nunez-Fontarnau J, Kiiskinen TTJ, Soderlund S, Matikainen N, Gerl MJ, Surma MA, Klose C, Stitziel NO, Laivuori H, Havulinna AS, Service SK, Salomaa V, Pirinen M, Jauhiainen M, Daly MJ, Freimer NB, Palotie A, Taskinen MR, Simons K, Ripatti S, Jalanko A, Kaprio J, Donner K, Kaunisto M, Mars N, Dada A, Shcherban A, Ganna A, Lehisto A, Kilpelainen E, Brein G, Awaisa G, Harju J, Parr K, Parolo PD, Kajanne R, Lemmela S, Sipila TP, Sipila T, Lyhs U, Llorens V, Niiranen T, Kristiansson K, Mannikko L, Jimenez MG, Perola M, Wong R, Kilpi T, Hiekkalinna T, Jarvensivu E, Kaiharju E, Mattsson H, Laukkanen M, Laiho P, Lahteenmaki S, Sistonen T, Soini S, Ziemann A, Lehtonen A, Lertratanakul A, Georgantas B, Riley-Gillis B, Quarless D, Rahimov F, Heap G, Jacob H, Waring J, Davis JW, Smaoui N, Popovic R, Esmaeeli S, Waring J, Matakidou A, Challis B, Close D, Petrovski S, Karlsson A, Schleutker J, Pulkki K, Virolainen P, Kallio L, Mannermaa A, Heikkinen S, Kosma VM, Chen CY, Runz H, Liu J, Bronson P, John S, Landenpera S, Eaton S, Zhou W, Hendolin M, Tuovila O, Pakkanen R, Maranville J, Usiskin K, Hochfeld M, Plenge R, Yang R, Biswas S, Greenberg S, Laakkonen E, Kononen J, Paloneva J, Kujala U, Kuopio T, Laukkanen J, Kangasniemi E, Savinainen K, Laaksonen R, Arvas M, Ritari J, Partanen J, Hyvarinen K, Wahlfors T, Peterson A, Oh D, Chang D, Teng E, Strauss E, Kerchner G, Chen H, Chen H, Schutzman J, Michon J, Hunkapiller J, McCarthy M, Bowers N, Lu T, Bhangale T, Pulford D, Waterworth D, Kulkarni D, Xu FL, Betts J, Gordillo JE, Hoffman J, Auro K, McCarthy L, Ghosh S, Ehm M, Pitkanen K, Makela T, Loukola A, Joensuu H, Sinisalo J, Eklund K, Aaltonen L, Farkkila M, Carpen O, Kauppi P, Tienari P, Ollila T, Tuomi T, Meretoja T, Pitkaranta A, Turunen J, Hannula-Jouppi K, Pikkarainen S, Seitsonen S, Koskinen M, Palomaki A, Rinne J, Metsarinne K, Elenius K, Pirila L, Koulu L, Voutilainen M, Juonala M, Peltonen S, Aaltonen V, Loboda A, Podgornaia A, Chhibber A, Chu A, Fox C, Diogo D, Holzinger E, Eicher J, Gormley P, Mehta V, Wang XL, Kettunen J, Pylkas K, Kalaoja M, Karjalainen M, Hinttala R, Kaarteenaho R, Vainio S, Mantere T, Remes A, Huhtakangas J, Junttila J, Tasanen K, Huilaja L, Luodonpaa M, Hautala N, Karihtala P, Kauppila S, Harju T, Blomster T, Soininen H, Harvima I, Pihlajamaki J, Kaarniranta K, Pelkonen M, Laakso M, Hiltunen M, Kiviniemi M, Kaipiainen-Seppanen O, Auvinen P, Kalviainen R, Julkunen V, Malarstig A, Hedman A, Marshal C, Whelan C, Lehtonen H, Parkkinen J, Linden K, Kalpala K, Miller M, Bing N, McDonough S, Chen X, Hu XL, Wu Y, Auranen A, Jussila A, Uusitalo-Jarvinen H, Kankaanranta H, Uusitalo H, Peltola J, Kahonen M, Isomaki P, Laitinen T, Salmi T, Muslin A, Wang C, Chatelain C, Xu E, Auge F, Call K, Klinger K, Crohns M, Gossel M, Palin K, Rivas M, Siirtola H, Tabuenca JG
- Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulation (2019) Tamirat M., Koivu M., Elenius K., Johnson M.
- The Mutational Profile of Unicystic Ameloblastoma (2019)
- Journal of Dental Research
Heikinheimo K, Huhtala JM, Thiel A, Kurppa KJ, Heikinheimo H, Kovac M, Kragelund C, Warfvinge G, Dawson H, Elenius K, Ristimäki A, Baumhoer D, Morgan PR
- Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin (2018) Narvi E, Vaparanta K, Karrila A, Chakroborty D, Knuutila S, Pulliainen A, Sundvall M, Elenius K
- Geenidiagnostiikkaan perustuva syövän hoito - tätä päivää, tulevaisuutta vai toiveajattelua? (2018) Alanne E, Joensuu H, Elenius K
- Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target (2018)
- BMC Cardiovascular Disorders
Juho Heliste, Anne Jokilammi, Ilkka Paatero, Deepankar Chakroborty, Christoffer Stark, Timo Savunen, Maria Laaksonen, Klaus Elenius
- Genome-wide screen of gamma-secretase-mediated intramembrane cleavage of receptor tyrosine kinases (2017)
- Molecular Biology of the Cell
Merilahti JAM, Ojala VK, Knittle AM, Pulliainen AT, Elenius K
- Human Metaplastic Breast Carcinoma and Decorin (2017) Boström P, Sainio A, Eigėlienė N, Jokilammi A, Elenius K, Koskivuo I, Järveläinen H
- SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase (2017)
- Journal of Biological Chemistry
Knittle AM, Helkkula M, Johnson MS, Sundvall M, Elenius K
- Activating ERBB4 mutations in non-small cell lung cancer (2016) Kurppa K., Denessiouk K., Johnson M., Elenius K.
- Farmakogenetiikka saapuu klinikkaan (2016) Juho Heliste, Klaus Elenius, Mikko Niemi, Varpu Elenius
- Novel Targets for the Treatment of Ameloblastoma (2015)
- Journal of Dental Research
K. Heikinheimo, K.J. Kurppa, K. Elenius
- ErbB4, a receptor tyrosine kinase, coordinates organization of the seminiferous tubules in the developing testis. (2014)
- Molecular Endocrinology -Baltimore-
Florence Naillat, Ville Veikkolainen, Ilkka Miinalainen, Petra Sipilä, Matti Poutanen, Klaus Elenius, Seppo J. Vainio
- ERBB4 Promoter Polymorphism Is Associated with Poor Distant Disease-Free Survival in High-Risk Early Breast Cancer (2014) Kari J. Kurppa, Matjaz Rokavec, Maria Sundvall, Pirkko-Liisa Kellokumpu-Lehtinen, Heikki Joensuu, Hiltrud Brauch, Klaus Elenius
- High frequency of BRAF V600E mutations in ameloblastoma (2014) Kari J Kurppa, Javier Catón, Peter R Morgan, Ari Ristimäki, Blandine Ruhin, Jari Kellokoski, Klaus Elenius, Kristiina Heikinheimo
- Hypoxia-inducible Factor-1α Induces ErbB4 Signaling in the Differentiating Mammary Gland (2014)
- Journal of Biological Chemistry
Ilkka Paatero, Tiffany N. Seagroves, Katri Vaparanta, Wen Han, Frank E. Jones, Randall S. Johnson, Klaus Elenius
- Overexpression of ERBB4 JM-a CYT-1 and CYT-2 isoforms in transgenic mice reveal isoform-specific roles in mammary gland development and carcinogenesis (2014) Vikram B Wali, Maureen Gilmore-Hebert, Ramanaiah Mamillapalli, Jonathan W Haskins, Kari J Kurppa, Klaus Elenius, Carmen J Booth, David F Stern
- Sähköiset potilastietojärjestelmät geenitestien hyödyntämisessä (2014) Elenius K, Kankuri-Tammilehto M
- CYT-1 isoform of ErbB4 is an independent prognostic factor in serous ovarian cancer and selectively promotes ovarian cancer cell growth in vitro (2013) Paatero I, Lassus H, Junttila TT, Kaskinen M, Butzow R, Elenius K
