Pirkko Heikinheimo

- Teacher,
Department of Teacher Education (Turku) (Department of Teacher Education)
- Docent,
Faculty of Science (University of Turku)

Department of Biochemistry and Turun Normaalikoulu

pirkko.heikinheimo@utu.fi

Tykistökatu 6

Turku

: B205

2 of 2

The structure of bovine lysosomal alpha-mannosidase suggests a novel mechanism for low-pH activation (2003) Heikinheimo P, Helland R, Leiros HKS, Leiros I, Karlsen S, Evjen G, Ravelli R, Schoehn G, Ruigrok R, Tollersrud OK, McSweeney S, Hough E
Functional and structural characterization of disease-causing mutations in alpha-mannosidosis. (2002)
- American Journal of Human Genetics
Conference proceedings Stensland HMFR, Hansen GM, Heikinheimo P, Tollersrud OK, Nilssen Ø
Expression and glycosylation studies of human FGF receptor 4 (2001)
- Protein Expression and Purification
Tuominen H, Heikinheimo P, Loo B-M, Kataja K, Oker-Blom C, Uutela M, Jalkanen M, Goldman A
Toward a quantum-mechanical description of metal-assisted phosphoryl transfer in pyrophosphatase (2001) Heikinheimo P, Tuominen V, Ahonen AK, Teplyakov A, Cooperman BS, Baykov AA, Lahti R, Goldman A
Production and purification of recombinant human (alpha 2)C2 adrenergic receptor using Saccharomyces cerevisiae (2000)
- Bioseparation
Kapat A, Jaakola VP, Heimo H, Liitti S, Heikinheimo P, Glumoff T, Goldman A
Of barn owls and bankers: a lush variety of alpha/beta hydrolases (1999)
- Structure
Heikinheimo P, Goldman A, Jeffries C, Ollis DL
The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: Structural studies and mechanistic implications (1998) Tuominen V, Heikinheimo P, Kajander T, Torkkel T, Hyytia T, Kapyla J, Lahti R, Cooperman BS, Goldman A
Structural and functional consequences of substitutions at the tyrosine 55 lysine 104 hydrogen bond in Escherichia coli inorganic pyrophosphatase (1997) Fabrichniy IP, Kasho VN, Hyytia T, Salminen T, Halonen P, Dudarenkov VY, Heikinheimo P, Chernyak VY, Goldman A, Lahti R, Cooperman BS, Baykov AA
The three metal ion mechanism of inorganic pyrophosphatases (1997)
- Protein Engineering
Heikinheimo P, Tuominen V, Lahti R, Cooperman BS, Goldman A
A site-directed mutagenesis study of Saccharomyces cerevisiae pyrophosphatase - Functional conservation of the active site of soluble inorganic pyrophosphatases (1996)
- European Journal of Biochemistry
Heikinheimo P, Pohjanjoki P, Helminen A, Tasanen M, Cooperman BS, Goldman A, Baykov A, Lahti R
The structural basis for pyrophosphatase catalysis (1996)
- Structure
Heikinheimo P, Lehtonen J, Baykov A, Lahti R, Cooperman BS, Goldman A
New crystal forms of Escherichia coli and Saccharomyces cerevisiae soluble inorganic pyrophosphatases (1995)
- Acta Crystallographica Section D: Biological Crystallography
HEIKINHEIMO P, SALMINEN T, LAHTI R, COOPERMAN B, GOLDMAN A
Structure and function analysis of Escherichia coli inorganic pyrophosphatase: is a hydroxide ion the key to catalysis? (1995)
- Biochemistry
Salminen T, Käpylä J, Heikinheimo P, Kankare J, Goldman A, Heinonen J, Baykov AA, Cooperman BS, Lahti R.
Characterization of the 5′ flanking region of the Escherichia coli ppa gene encoding inorganic pyrophosphatase: mutations in the ribosome-binding site decrease the level of ppa mRNA (1991)
- Journal of general microbiology
Lahti R, Perälä M, Heikinheimo P, Pitkäranta T, Kukko-Kalske E, Heinonen J
Genetic engineering of Escherichia coli inorganic pyrophosphatase
Tyr55 and Tyr141 are important for the structural integrity (1991)
- European Journal of Biochemistry
LAHTI R, SALMINEN T, LATONEN S, HEIKINHEIMO P, POHJANOKSA K, HEINONEN J
A site-directed mutagenesis study on Escherichia coli inorganic pyrophosphatase. Glutamic acid-98 and lysine-104 are important for structural integrity, whereas aspartic acids-97 and -102 are essential for catalytic activity (1990) LAHTI R, POHJANOKSA K, PITKARANTA T, HEIKINHEIMO P, SALMINEN T, MEYER P, HEINONEN J