Riikka Lund
Epigenomiikka; genomiikka; pluripotentit kantasolut; biolääketiede; sairauksien molekyylitason mekanismit
Riikka Lund is a Reseach Director (10 %) at the Turku Bioscience Centre and works also as a Senior Scientist, Bioinformatics, at Orion. She completed her M.Sc. degree in 2001 with a major in genetics at the Department of Biology, Faculty of Mathematics and Natural Sciences, University of Turku, Finland. She carried out part of her studies at the Royal Melbourne institute of Technology, Australia. She gained her PhD in 2004 in Molecular Immunology and Medical Genetics at the Faculty of Medicine, University of Turku. She did her postdoc at the Centre for Stem Cell Biology, University of Sheffield in 2007-2008 with the focus on understanding genomic stability of pluripotent stem cells. In addition, to develop her expertise and update her skills in the latest technologies and research methods, she has carried out several short visits to national and international units (e.g. 2018 University of Southern Denmark; 2013 Broad Institute, USA; 2011 Diagenode, Belgium; 2009, 2006 University of Sheffied, UK; 2005 University of California, USA; 2002 Affymetrix, USA; 2001 Deutches Rheuma-Forschungszentrum, Germany). In 2013 she was awarded with the Millenium Distinct Technology Award for her contributions in stem cell research. In 2014 she become Adjunct Professor in Molecular Biology in the faculty of Medicine, University of Turku. In 2013-2022 she worked as the head of Finnish Functional Genomics Centre, a functional genomics core facility operating in Turku, Finland. In addition, she lead the Biomedical Epigenomics research group and was engaged in teaching. She has also been co-PI in the Biocenter Finland Genome-wide methods platform (https://www.biocenter.fi/index.php/technology-platform-services/genome-wide-methods), in 2016-2022 was a co-director of the Computational and Molecular Methodologies for Life Sciences (CompLifeSci) Biocity Turku Research Programme and has served in many other international expertise task, such as editorial board member of Scientific Reports journal.
Biomedical Epigenomics group run by Lund exploits the latest technologies and cutting-edge methods to study genome function during early human development, aging and in diseases. The aim of the research is to understand how genetic and environmental factors influence development and health status of an individual and to reveal the molecular mechanisms of disease development. Furthermore, the goal is to find novel type of disease marker candidates and targets for drug development. By providing novel innovative approaches enabling prediction, early diagnosis and efficient precision treatment of diseases the ultimate goal of this research is to promote lifelong health.
Epigenomiikka; genomiikka; transkriptomiikka; "next-generation" sekvensointi; kantasolut ja regeneratiivinen lääketiede.
- From maternal glucocorticoid and thyroid hormones to epigenetic regulation of offspring gene expression: An experimental study in a wild bird species (2023)
- Evolutionary Applications
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Early DNA methylation changes in children developing beta cell autoimmunity at a young age (2022)
- Diabetologia
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - LuxRep: a technical replicate-aware method for bisulfite sequencing data analysis (2022)
- BMC Bioinformatics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples (2022)
- Epigenetics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Umbilical cord blood DNA methylation in children who later develop type 1 diabetes (2022)
- Diabetologia
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Evaluation of tools for identifying large copy number variations from ultra-low-coverage whole-genome sequencing data (2021)
- BMC Genomics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Placental DNA methylation marks are associated with maternal depressive symptoms during early pregnancy (2021)
- Neurobiology of Stress
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Analysis of H3K4me3 and H3K27me3 bivalent promotors in HER2+ breast cancer cell lines reveals variations depending on estrogen receptor status and significantly correlates with gene expression (2020)
- BMC Medical Genomics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Plasma cell-free DNA methylation marks for episodic memory impairment: a pilot twin study (2020)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities (2020)
- Genome Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Decorin Expression and Oncosuppression in Human Embryonic Carcinomas (2019)
- Archives of Clinical and Medical Case Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Early Detection of Peripheral Blood Cell Signature in Children Developing Beta-Cell Autoimmunity at a Young Age (2019)
- Diabetes
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer's disease (2019)
- Clinical Epigenetics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The impact of probiotic supplementation during pregnancy on DNA methylation of obesity-related genes in mothers and their children (2019)
- European Journal of Nutrition
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Atopic asthma after rhinovirus-induced wheezing is associated with DNA methylation change in the SMAD3 gene promoter (2018)
- Allergy: European Journal of Allergy and Clinical Immunology: Supplement
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer (2017)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Epigenomic Landscapes of hESC-Derived Neural Rosettes: Modeling Neural Tube Formation and Diseases (2017)
- Cell Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Methylome Analysis of Human Bone Marrow MSCs Reveals Extensive Age- and Culture-Induced Changes at Distal Regulatory Elements (2017)
- Stem Cell Reports
Petri Lehenkari, Riikka Lund, Saara Laitinen, R. David Hawkins
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA+ and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells (2017)
- Stem Cell Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Activation of Plasmacytoid Dendritic Cells in Colon-Draining Lymph Nodes during Citrobacter rodentium Infection Involves Pathogen-Sensing and Inflammatory Pathways Distinct from Conventional Dendritic Cells (2016)
- Journal of Immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )