Martti Tolvanen
PhD
martti.tolvanen@utu.fi Vesilinnantie 5 Turku ORCID-tunniste: https://orcid.org/0000-0003-3434-7646 |
Bioinformatiikka; Genomiikka; Molekyylievoluutio; Biokemia; Proteiinrakenteet; Glykobiologia
I collaborate with a group at Tampere University led by prof. Seppo Parkkila, on carbonic anhydrases.
I am a biochemist who turned into a bioinformatician during 1990's. I got an MSc in 1986 and Ph.Lic in 1989, both in biochemistry at the University of Helsinki. I did my PhD at the U of Tampere based on my research there from 2004 to 2012. I became a PhD student in 2012 and defended my thesis in 2013. I have worked at the U of Helsinki from 1985 to 1997; North Karelia Polytechnic from 1998 to 2001; U of Tampere 2001 to 2013, and U of Turku 2013 to present.
My research topic is bioinformatics of carbonic anhydrases, focusing on genomics, molecular evolution and structural aspects, such as protein and glycoprotein modelling.
I have developed and taught at least six different bioinformatics courses and taught several courses developed by others. My main specialities and greatest interest areas in teaching are research tools in molecular bioinformatics, in particular sequence analyses and comparisons, use of bioinformatics databases, and structural bioinformatics for work with protein 3D structures. My main teaching method is learning by doing, which means that all theoretical concepts are understood better when applied in the context of actual problem-solving and pursuit of understanding biomolecules and biological processes with the help of bioinformatics tools.
I have a been teaching at Finnish Universities for more than 30 years, and since 2001 I have developed on-line teaching in bioinformatics. Since 2006 I have been teaching in international master's degree programmes of bioinformatics, and more recently in wider MSc programmes which include bioinformatics as one specialization line.
On-line teaching is also a special interest of mine, from long before the pandemic times. At the U of Tampere I was part of a three-person team (Lehtiniemi-Tolvanen-Vihinen) who won the national award of on-line teaching of the Finnish Ministry of Education, in 2002.
The courses which I have been teaching in the current curriculum cycle include Bioinformatics Methods, Structural Bioinformatics, Algorithms in Bioinformatics, and Bioinformatics Project, in addition to thesis supervising and co-supervising, and being a member is various PhD thesis committees.
- Mycobacterial β-carbonic anhydrases : Molecular biology, role in the pathogenesis of tuberculosis and inhibition studies (2024)
- EnzymesJournal of Enzyme Inhibition and Medicinal Chemistry
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa) - Cloning, characterization, and inhibition of the novel beta-carbonic anhydrase from parasitic blood fluke, Schistosoma mansoni (2023)
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Biochemical and Biophysical Characterization of Carbonic Anhydrase VI from Human Milk and Saliva (2022)
- Protein Journal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology (2022)
- Physiological Reviews
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth Gyrodactylus salaris (2022)
- Journal of Enzyme Inhibition and Medicinal Chemistry
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Neural Network and Random Forest Models in Protein Function Prediction (2022)
- IEEE/ACM Transactions on Computational Biology and Bioinformatics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Carbonic anhydrases from pathogens: Protozoan CAs and related inhibitors as potential antiprotozoal agents (2019) Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target Ashok Aspatwar, Harlan Barker, Martti Tolvanen, Reza Zolfaghari Emameh, Seppo Parkkila
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa) - Catalytically inactive carbonic anhydrase-related proteins enhance transport of lactate by MCT1 (2019)
- FEBS Open Bio
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Engineered Carbonic Anhydrase VI-Mimic Enzyme Switched the Structure and Affinities of Inhibitors (2019)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens (2019)
- Genome Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Herbal Drug Use In Sickle Cell Disease Management; Trends And Perspectives In Sub-Saharan Africa (2018)
- Current Drug Discovery Technologies
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Identification and characterization of a novel zebrafish (Danio rerio) pentraxin-carbonic anhydrase (2017)
- PeerJ
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Horizontal transfer of beta-carbonic anhydrase genes from prokaryotes to protozoans, insects, and nematodes (2016)
- Parasites and Vectors
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Inactivation of ca10a and ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish (2015)
- PLoS ONE
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The beta-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides (2015)
- Bioorganic and Medicinal Chemistry
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Beta carbonic anhydrases: novel targets for pesticides and anti-parasitic agents in agriculture and livestock husbandry (2014)
- Parasites and Vectors
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Bioinformatic analysis of beta carbonic anhydrase sequences from protozoans and metazoans (2014)
- Parasites and Vectors
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Characterization of Non-Specific Cytotoxic Cell Receptor Protein 1: A New Member of the Lectin-Type Subfamily of F-Box Proteins (2011)
- PLoS ONE
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Carbonic anhydrase related protein VIII and its role in neurodegeneration and cancer (2010)
- Current Pharmaceutical Design
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Carbonic anhydrase related protein VIII and its role in neurodegeneration and cancer (2010)
- Current Pharmaceutical Design
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)