Semi Helin - UTU Research Portal - UTU Research Portal

Semi Helin

- Senior Researcher,
Turku PET Centre (Independent units)

semhel@utu.fi

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Intranasal naloxone rapidly occupies brain mu-opioid receptors in human subjects (2019)
- Neuropsychopharmacology
Jarkko Johansson, Jussi Hirvonen, Zsófia Lovró, Laura Ekblad, Valtteri Kaasinen, Olli Rajasilta, Semi Helin, Jouni Tuisku, Saija Sirén, Mirka Pennanen, Arvind Agrawal, Roger Crystal, Petri J. Vainio, Hannu Alho, Mika Scheinin
Midlife Insulin Resistance as a Predictor for Late-Life Cognitive Function and Cerebrovascular Lesions (2019)
- Journal of Alzheimer's Disease
Toppala S, Ekblad LL, Lotjonen J, Helin S, Hurme S, Johansson J, Jula A, Karrasch M, Koikkalainen J, Laine H, Parkkola R, Viitanen M, Rinne JO
Regulation of human brown adipose tissue by adenosine and A2A receptors – studies with [15O]H2O and [11C]TMSX PET/CT (2019)
- European Journal of Nuclear Medicine and Molecular Imaging
Minna Lahesmaa, Vesa Oikonen, Semi Helin, Pauliina Luoto, Mueez U Din, Alexander Pfeifer, Pirjo Nuutila, Kirsi A. Virtanen
Binge eating disorder and morbid obesity are associated with lowered mu-opioid receptor availability in the brain (2018)
- Psychiatry Research: Neuroimaging
Juho Joutsa, Henry K. Karlsson, Joonas Majuri,, Pirjo Nuutila, Semi Helin, Valtteri Kaasinen, Lauri Nummenmaa
Correction to: Regulation of human brown adipose tissue by adenosine and A2A receptors – studies with [15O]H2O and [11C]TMSX PET/CT (2018)
- European Journal of Nuclear Medicine and Molecular Imaging
Minna Lahesmaa, Vesa Oikonen, Semi Helin, Pauliina Luoto, Mueez U Din, Alexander Pfeifer, Pirjo Nuutila, Kirsi A. Virtanen
Midlife insulin resistance, APOE genotype, and late-life brain amyloid accumulation (2018)
- Neurology
Ekblad LL, Johansson J, Helin S, Viitanen M, Laine H, Puukka P, Jula A, Rinne JO
Neuroinflammation appears early and then plateaus in a mouse model of Alzheimer's disease shown by PET imaging (2018)
- Journal of Nuclear Medicine
Francisco R. López-Picón, Anniina Snellman, Olli Eskola, Semi Helin, Olof Solin, Merja Haaparanta-Solin, Juha O. Rinne
S-[F-18] THK-5117-PET and [C-11] PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-beta Plaques and Tau in Brain Biopsies (2018)
- Journal of Alzheimer's Disease
Leinonen V, Rauramaa T, Johansson J, Bottelbergs A, Tesseur I, van der Ark P, Pemberton D, Koivisto AM, Jääskeläinen JE, Hiltunen M, Herukka SK, Blennow K, Zetterberg H, Jokinen P, Rokka J, Heliu S, Haaparanta-Solin M, Solin O, Okamura N, Kolb HC, Rinne JO
Applicability of [C-11]PIB micro-PET imaging for in vivo follow-up of anti-amyloid treatment effects in APP23 mouse model (2017)
- Neurobiology of Aging
Snellman A, Rokka J, Lopez-Picon FR, Helin S, Re F, Löyttyniemi E, Pihlaja R, Forloni G, Salmona M, Masserini M, Solin O, Rinne JO, Haaparanta-Solin M
Brain glucose metabolism and its relation to amyloid load in middle-aged adults with childhood-onset epilepsy (2017)
- Epilepsy Research
Juho Joutsa, Juha O. Rinne, Mira Karrasch, Bruce Hermann, Jarkko Johansson, Anu Anttinen, Olli Eskola, Semi Helin, Shlomo Shinnar, Matti Sillanpää; TACOE study group
Feeding Releases Endogenous Opioids in Humans (2017)
- Journal of Neuroscience
Tuulari JJ, Tuominen L, de Boer FE, Hirvonen J, Helin S, Nuutila P, Nummenmaa L
Neurotransmitters behind pain relief with transcranial magnetic stimulation - positron emission tomography evidence for release of endogenous opioids (2017)
- European Journal of Pain
Lamusuo S, Hirvonen J, Lindholm P, Martikainen IK, Hagelberg N, Parkkola R, Taiminen T, Hietala J, Helin S, Virtanen A, Pertovaara A, Jaaskelainen SK
Bariatric surgery normalizes brain opioid receptors (2016)
- Molecular Psychiatry
Karlsson HK, Tuulari JJ, Tuominen L, Hirvonen J, Honka H, Parkkola R, Helin S, Salminen P, Nuutila P, Nummenmaa L
Weight loss after bariatric surgery normalizes brain opioid receptors in morbid obesity (2016)
- Molecular Psychiatry
Karlsson HK, Tuulari JJ, Tuominen L, Hirvonen J, Honka H, Parkkola R, Helin S, Salminen P, Nuutila P, Nummenmaa L
Aberrant mesolimbic dopamine-opiate interaction in obesity (2015)
- NeuroImage
Tuominen L, Tuulari J, Karlsson H, Hirvonen J, Helin S, Salminen P, Parkkola R, Hietala J, Nuutila P, Nummenmaa L
Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease (2015)
- Brain
Jucaite A, Svenningsson P, Rinne JO, Cselenyi Z, Varnas K, Johnstrom P, Amini N, Kirjavainen A, Helin S, Minkwitz M, Kugler AR, Posener JA, Budd S, Halldin C, Varrone A, Farde L
Lihavuus on yhteydessä opioidijärjestelmän muutokseen (2015)
- Duodecim
Karlsson Henry K, Tuominen Lauri, Tuulari Jetro J, Hirvonen Jussi, Parkkola Riitta, Helin Semi, Salminen Paulina, Nuutila Pirjo, Nummenmaa Lauri
Obesity Is Associated with Decreased mu-Opioid But Unaltered Dopamine D-2 Receptor Availability in the Brain (2015)
- Journal of Neuroscience
Karlsson HK, Tuominen L, Tuulari JJ, Hirvonen J, Parkkola R, Helin S, Salminen P, Nuutila P, Nummenmaa L
Test-retest reliability of (11)C-ORM-13070 in PET imaging of α2C-adrenoceptors in vivo in the human brain (2015)
- European Journal of Nuclear Medicine and Molecular Imaging
Jussi Lehto, Jere R. Virta, Vesa Oikonen, Anne Roivainen, Pauliina Luoto, Eveliina Arponen, Semi Helin, Johanna Hietamäki, Aila Holopainen, Marita Kailajärvi, Juha M. Peltonen, Juha Rouru, Jukka Sallinen, Kirsi Virtanen, Iina Volanen, Mika Scheinin, Juha O. Rinne
¹¹C-ORM-13070, a novel PET ligand for brain α₂C-adrenoceptors: radiometabolism, plasma pharmacokinetics, whole-body distribution and radiation dosimetry in healthy men. (2014)
- European Journal of Nuclear Medicine and Molecular Imaging
Luoto P, Suilamo S, Oikonen V, Arponen E, Helin S, Herttuainen J, Hietamäki J, Holopainen A, Kailajärvi M, Peltonen JM, Rouru J, Sallinen J, Scheinin M, Virta J, Virtanen K, Volanen I, Roivainen A, Rinne JO