Eleanor Coffey
 Research Director Åbo Akademi University, Vice Director Turku Bioscience Centre

  

  

  

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• JNK-regulated phosphoproteome links synaptic and metabolic pathways to mood regulation  (2026)  
  • Neurobiology of Disease
   Hong, Ye; Siino, Valentina; Flinkman, Dani; Deshpande, Prasannakumar; Martinez, Sylvia Ortega; Fagerholm, Veronica; Varidaki, Artemis; Heemeryck, Pierre; Sourander, Christel; James, Peter; Coffey, Eleanor

  
  

• FPmotion: Analysis software for fiber photometry data analysis  (2025)   Hong, Ye; Coffey, Eleanor

  
  

• JNK regulates GABAAR expression at the cell surface via the receptor clustering protein GIT1 (ArfGAP1)  (2025)  
  • bioRxiv
   Varidaki, Artemis; Deshpande, Prasannakumar; Nagaeva, Elina; Sino, Valentina; Schäfer, Annika; Sourander, Christel; Lagerholm, Christoffer; James, Peter; Korpi, Esa R.; Coffey, Eleanor

  
  

• LimROTS: A Hybrid Method Integrating Empirical Bayes and Reproducibility-Optimized Statistics for Robust Differential Expression Analysis  (2025)  
  • Bioinformatics
   Anwara, Ali Mostafa; Jeba, Akewak; Lahti, Leo; Coffey, Eleanor

  
  

• Chondroitin Sulfate-Coated Heteroduplex-Molecular Spherical Nucleic Acids  (2024)  
  • ChemBioChem
   Laine, Toni; Deshpande, Prasannakumar; Tähtinen, Ville; Coffey, Eleanor T.; Virta, Pasi

  
  

• Expanding the Molecular and Clinical Phenotype of Patients With De Novo Variants in KIF5C : A Six Patient Case Series  (2024)  
  • American Journal of Medical Genetics Part A
   Gracie, Sara; Deshpande, Prasannakumar; Hollos, Patrik; De Dios, Karl; Martin, Donna M.; Pritchard, Amanda B.; Scott Schwoerer, Jessica A.; Behrmann, Meghan R.; Seaver, Laurie H.; Brown, Kathleen; Fernandez, Raymond J.; Larson, Austin; Coffey, Eleanor

  
  

• Jnk1 and downstream signalling hubs regulate anxiety-like behaviours in a zebrafish larvae phenotypic screen  (2024)  
  • Scientific Reports
   Hong, Ye; Sourander, Christel; Hackl, Benjamin; Patton, Jedidiah S.; John, Jismi; Paatero, Ilkka; Coffey, Eleanor

  
  

• LimROTS Bioconductor software package  (2024)   Youssef, Ali; Jeba, Akewak; Lahti, Leo; Coffey, Eleanor

  
  

• Regulators of proteostasis are translationally repressed in fibroblasts from patients with sporadic and LRRK2-G2019S Parkinson’s disease  (2023)  
  • NPJ Parkinson's disease
   Flinkman Dani, Hong Ye, Gnjatovic Jelena, Deshpande Prasannakumar, Ortutay Zsuzsanna, Peltonen Sirkku, Kaasinen Valtteri, James Peter, Coffey Eleanor

  
  

• Long-term osteogenic differentiation of human bone marrow stromal cells in simulated microgravity: novel proteins sighted  (2022)  
  • Cellular and Molecular Life Sciences
   Montagna Giulia, Pani Giuseppe, Flinkman Dani, Cristofaro Francesco, Pascucci Barbara, Massimino Luca, Lamparelli Luigi A., Fassina Lorenzo, James Peter, Coffey Eleanor, Rea Giuseppina, Visai Livia, Rizzo Angela M.

  
  

• PhosPiR: an automated phosphoproteomic pipeline in R  (2022)  
  • Briefings in Bioinformatics
   Hong Ye, Flinkman Dani, Suomi Tomi, Pietilä Sami, James Peter, Coffey Eleanor, Elo Laura L

  
  

• SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling  (2021)  
  • Current Biology
   Salomaa Siiri I, Miihkinen Mitro, Kremneva Elena, Paatero Ilkka, Lilja Johanna, Jacquemet Guillaume, Vuorio Joni, Antenucci Lina, Kogan Konstantin, Hassani Nia Fatemeh, Hollos Patrik, Isomursu Aleksi, Vattulainen Ilpo, Coffey Eleanor T, Kreienkamp Hans-Jürgen, Lappalainen Pekka, Ivaska Johanna

  
  

• Impact of JNK and Its Substrates on Dendritic Spine Morphology  (2020)  
  • Cells
   Emilia Komulainen, Artemis Varidaki, Natalia Kulesskaya, Hasan Mohammad, Christel Sourander, Heikki Rauvala, Eleanor T. Coffey

  
  

• Optogenetic Control of Spine-Head JNK Reveals a Role in Dendritic Spine Regression  (2020)  
  • eNeuro
   Hollos P, John JM, Lehtonen JV, Coffey ET

  
  

• PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins  (2020)  
  • Cell communication and signaling
   Niina M. Santio, Veera Vainio, Tuuli Hoikkala, Kwan Long Mung, Mirka Lång, Riitta Vahakoski, Justyna Zdrojewska, Eleanor T. Coffey, Elena Kremneva, Eeva-Marja Rainio, Päivi J. Koskinen

  
  

• Protein synthesis is suppressed in sporadic and familial Parkinson's disease by LRRK2  (2020)  
  • FASEB Journal
   Prasannakumar Deshpande, Dani Flinkman, Ye Hong, Elena Goltseva, Valentina Siino, Lihua Sun, Sirkku Peltonen, Laura L. Elo, Valtteri Kaasinen, Peter James, Eleanor T. Coffey

  
  

• L-alpha-amino adipic acid provokes depression-like behaviour and a stress related increase in dendritic spine density in the pre-limbic cortex and hippocampus in rodents  (2019)  
  • Behavioural Brain Research
   David J., Gormley S., McIntosh A.L., Kebede V., Thuery G., Varidaki A., Coffey E.T., Harkin A.

  
  

• JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche  (2018)  
  • Molecular Psychiatry
   H Mohammad, F Marchisella, S Ortega-Martinez, P Hollos, K Eerola, E Komulainen, N Kulesskaya, E Freemantle, V Fagerholm, E Savontous, H Rauvala, B D Peterson, H van Praag, E T Coffey

  
  

• JNK Regulation of Depression and Anxiety  (2018)  
  • Brain Plasticity
   Patrik Hollos, Francesca Marchisella, Eleanor T. Coffey

  
  

• Repositioning Microtubule Stabilizing Drugs for Brain Disorders  (2018)  
  • Frontiers in Cellular Neuroscience
   Varidaki A, Hong Y, Coffey ET