Pekka Taimen
MD, PhD
pepeta@utu.fi +358 29 450 4524 +358 50 431 1353 Kiinamyllynkatu 10 Turku Office: D5019 ORCID identifier: https://orcid.org/0000-0001-8849-4604 Official web page of research group |
pathology; histology; cell biology; prostate cancer, bladder cancer, cardiomyopathy, nuclear lamin
Pekka Taimen received his MD degree from the University of Turku in 2001 and defended his thesis at the Department of Pathology, University of Turku in 2004. In 2008-2009 PT worked as a postdoctoral fellow in the laboratory of Prof. Robert D. Goldman, Northwestern University Medical School, Chicago. Postdoctoral studies focusing on nuclear intermediate filament proteins called lamins were further continued as a junior group leader after returning back to Turku in early 2010. In 2011 PT received a specialist degree in Pathology and since then he has worked as a part-time specialist at the Pathology Division, Turku University Hospital with special focus on uropathology. From 2012 PT has worked as a Clinical lecturer in Pathology and between 2015-2019 as a part-time Academy of Finland Clinical Researcher. PT was appointed as a tenure track Assistant Professor of Molecular Pathology in January 2019 and an Associate Professor in August 2020. In January 2022, PT was appointed as a Professor of Molecular Pathology and he currently serves as the head of the pathology unit at the Faculty of Medicine, University of Turku.
Professor Pekka Taimen has 20 years of experience in cell and molecular biology as well as in translational research. The main focus of his research group is on human diseases caused by lamin mutations, such as cardiomyopathies and premature aging syndrome. More recently, PT has also actively worked on prostate and bladder cancer related projects including novel biomarkers, biobanking, patient derived cell lines and improved imaging techniques utilizing digital pathology and machine learning approaches.
Pekka Taimen has more than 10 years of experience in teaching medical students at the Institute of Biomedicine, University of Turku. He has served first as a university teacher and from 2012 as a clinical lecturer. In 2015 PT received the Lecturer of the Year award in the Faculty of Medicine.
- LMNA Mutation c.917T > G (p.L306R) Leads to Deleterious Hyper-Assembly of Lamin A/C and Associates with Severe Right Ventricular Cardiomyopathy and Premature Aging (2015)
- Human Mutation
(A1 Refereed original research article in a scientific journal) - Mathematical models for diffusion-weighted imaging of prostate cancer using b values up to 2000 s/mm2: Correlation with Gleason score and repeatability of region of interest analysis (2015)
- Magnetic Resonance in Medicine
(A1 Refereed original research article in a scientific journal) - Prebiopsy multiparametric 3T prostate MRI in patients with elevated PSA, normal digital rectal examination, and no previous biopsy (2015)
- Journal of Magnetic Resonance Imaging
(A1 Refereed original research article in a scientific journal) - Suppression of endothelial CD39/ENTPD1 is associated with pulmonary vascular remodeling in pulmonary arterial hypertension (2015)
- AJP - Lung Cellular and Molecular Physiology
(A1 Refereed original research article in a scientific journal) - Tumor-Associated Macrophages Provide Significant Prognostic Information in Urothelial Bladder Cancer (2015)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Bulbourethral gland adenocarcinoma in a 25-year-old man without comorbidities – Radical resection of proximal urethrae with Mitrofanoff-type appendicovesicostomy (2014)
- Scandinavian Journal of Urology and Nephrology
(B1 Non-refereed article in a scientific journal) - Lanthanide chelate complementation and hydrolysis enhanced luminescent chelate in real-time reverse transcription polymerase chain reaction assays for KLK3 transcripts (2014)
- Analytical Biochemistry
(A1 Refereed original research article in a scientific journal) - Loss of bone morphogenetic protein receptor 2 is associated with abnormal DNA repair in pulmonary arterial hypertension (2014)
- American Journal of Respiratory Cell and Molecular Biology
(A1 Refereed original research article in a scientific journal) - Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis (2014)
- Journal of Clinical Investigation
(A1 Refereed original research article in a scientific journal) - Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer (2014)
- European Medical Journal Urology
(A1 Refereed original research article in a scientific journal) - Patient-derived tissue culture and xenograft models for studying prostate tumor responses to therapy (2014)
- European Journal of Cancer
(Other publication) - Role of ultrasensitive prostate-specific antigen in the follow-up of prostate cancer after radical prostatectomy (2014)
- Urologic Oncology: Seminars and Original Investigations
(A1 Refereed original research article in a scientific journal) - Videoavusteinen obduktio-opetus (2014)
- Yliopistopedagogiikka
(D1 Article in a professional journal) - Attenuated Endothelial Cd39 Activity Mediates Vascular Remodeling in Pulmonary Arterial Hypertension (2013)
- Circulation
(Other publication) - Chromosomal regions associated with prostate cancer risk localize to lamin B-deficient microdomains and exhibit reduced gene transcription (2012)
- Journal of Pathology
(A1 Refereed original research article in a scientific journal) - Therapeutic potential of thymosin beta 4 in myocardial infarct and heart failure (2012)
- Annals of the New York Academy of Sciences
(A1 Refereed original research article in a scientific journal) - Topical cis-urocanic acid attenuates oedema and erythema in acute and subacute skin inflammation in the mouse (2012)
- British Journal of Dermatology
(A1 Refereed original research article in a scientific journal) - Nuclear Lamins (2010)
- Cold Spring Harbor Perspectives in Biology
(A2 Refereed review article in a scientific journal ) - Protodynamic Intracellular Acidification by cis-Urocanic Acid Promotes Apoptosis of Melanoma Cells In Vitro and In Vivo (2010)
- Journal of Investigative Dermatology
(A1 Refereed original research article in a scientific journal) - Silencing of Nuclear Mitotic Apparatus protein (NuMA) accelerates the apoptotic disintegration of the nucleus (2010)
- Apoptosis
(A1 Refereed original research article in a scientific journal)