Pekka Taimen
MD, PhD
pepeta@utu.fi +358 29 450 4524 +358 50 431 1353 Kiinamyllynkatu 10 Turku Office: D5019 ORCID identifier: https://orcid.org/0000-0001-8849-4604 Official web page of research group |
pathology; histology; cell biology; prostate cancer, bladder cancer, cardiomyopathy, nuclear lamin
Pekka Taimen received his MD degree from the University of Turku in 2001 and defended his thesis at the Department of Pathology, University of Turku in 2004. In 2008-2009 PT worked as a postdoctoral fellow in the laboratory of Prof. Robert D. Goldman, Northwestern University Medical School, Chicago. Postdoctoral studies focusing on nuclear intermediate filament proteins called lamins were further continued as a junior group leader after returning back to Turku in early 2010. In 2011 PT received a specialist degree in Pathology and since then he has worked as a part-time specialist at the Pathology Division, Turku University Hospital with special focus on uropathology. From 2012 PT has worked as a Clinical lecturer in Pathology and between 2015-2019 as a part-time Academy of Finland Clinical Researcher. PT was appointed as a tenure track Assistant Professor of Molecular Pathology in January 2019 and an Associate Professor in August 2020. In January 2022, PT was appointed as a Professor of Molecular Pathology and he currently serves as the head of the pathology unit at the Faculty of Medicine, University of Turku.
Professor Pekka Taimen has 20 years of experience in cell and molecular biology as well as in translational research. The main focus of his research group is on human diseases caused by lamin mutations, such as cardiomyopathies and premature aging syndrome. More recently, PT has also actively worked on prostate and bladder cancer related projects including novel biomarkers, biobanking, patient derived cell lines and improved imaging techniques utilizing digital pathology and machine learning approaches.
Pekka Taimen has more than 10 years of experience in teaching medical students at the Institute of Biomedicine, University of Turku. He has served first as a university teacher and from 2012 as a clinical lecturer. In 2015 PT received the Lecturer of the Year award in the Faculty of Medicine.
- (2016)
- Urologic Oncology: Seminars and Original InvestigationsPLoS ONEHuman Mutation
(A1 Refereed original research article in a scientific journal) - Systemic Dosing of Thymosin Beta 4 before and after Ischemia Does Not Attenuate Global Myocardial Ischemia-Reperfusion Injury in PigsEvaluation of different mathematical models for diffusion-weighted imaging of normal prostate and prostate cancer using high b-values: A repeatability study (2016)
- Frontiers in PharmacologyJournal of Magnetic Resonance Imaging
(A1 Refereed original research article in a scientific journal) - Validation of Novel Biomarkers for Prostate Cancer Progression by the Combination of Bioinformatics, Clinical and Functional StudiesDifferential predictive roles of A- and B-type nuclear lamins in prostate cancer progression (2016)
- PLoS ONENucleus
(A1 Refereed original research article in a scientific journal) - Altered PCA3 and TMPRSS2-ERG expression in histologically benign regions of cancerous prostates: a systematic, quantitative mRNA analysis in five prostatesLMNA Mutation c.917T > G (p.L306R) Leads to Deleterious Hyper-Assembly of Lamin A/C and Associates with Severe Right Ventricular Cardiomyopathy and Premature Aging (2015)
- BMC UrologyMagnetic Resonance in Medicine
(A1 Refereed original research article in a scientific journal) - (2015)
(A1 Refereed original research article in a scientific journal) - Diffusion-weighted imaging of prostate cancer: effect of b-value distribution on repeatability and cancer characterization (2015)
- Magnetic Resonance Imaging
(A1 Refereed original research article in a scientific journal) - Suppression of endothelial CD39/ENTPD1 is associated with pulmonary vascular remodeling in pulmonary arterial hypertension (2015)
(A1 Refereed original research article in a scientific journal) - Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells (2015)
(A1 Refereed original research article in a scientific journal) - (2015)
(A1 Refereed original research article in a scientific journal) - Mathematical models for diffusion-weighted imaging of prostate cancer using b values up to 2000 s/mm2: Correlation with Gleason score and repeatability of region of interest analysis (2015)
- Magnetic Resonance in Medicine
(A1 Refereed original research article in a scientific journal) - Prebiopsy multiparametric 3T prostate MRI in patients with elevated PSA, normal digital rectal examination, and no previous biopsy (2015)
(A1 Refereed original research article in a scientific journal) - (2015)
- AJP - Lung Cellular and Molecular Physiology
(A1 Refereed original research article in a scientific journal) - Tumor-Associated Macrophages Provide Significant Prognostic Information in Urothelial Bladder CancerLanthanide chelate complementation and hydrolysis enhanced luminescent chelate in real-time reverse transcription polymerase chain reaction assays for KLK3 transcriptsMutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis (2015)
- PLoS ONE
(A1 Refereed original research article in a scientific journal) - Bulbourethral gland adenocarcinoma in a 25-year-old man without comorbidities – Radical resection of proximal urethrae with Mitrofanoff-type appendicovesicostomy (2014)
- Scandinavian Journal of Urology and NephrologyAnalytical Biochemistry
(B1 Non-refereed article in a scientific journal) - (2014)
(A1 Refereed original research article in a scientific journal) - Loss of bone morphogenetic protein receptor 2 is associated with abnormal DNA repair in pulmonary arterial hypertensionPatient-derived tissue culture and xenograft models for studying prostate tumor responses to therapy (2014)
- American Journal of Respiratory Cell and Molecular BiologyUrologic Oncology: Seminars and Original Investigations
- (2014)
- Journal of Clinical Investigation
(A1 Refereed original research article in a scientific journal) - Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer (2014)
- European Medical Journal Urology
(A1 Refereed original research article in a scientific journal) - 2014
- European Journal of Cancer
(Other publication) - (2014)
(A1 Refereed original research article in a scientific journal)



