Pekka Taimen
MD, PhD
pepeta@utu.fi +358 29 450 4524 +358 50 431 1353 Kiinamyllynkatu 10 Turku Office: D5019 ORCID identifier: https://orcid.org/0000-0001-8849-4604 Official web page of research group |
pathology; histology; cell biology; prostate cancer, bladder cancer, cardiomyopathy, nuclear lamin
Pekka Taimen received his MD degree from the University of Turku in 2001 and defended his thesis at the Department of Pathology, University of Turku in 2004. In 2008-2009 PT worked as a postdoctoral fellow in the laboratory of Prof. Robert D. Goldman, Northwestern University Medical School, Chicago. Postdoctoral studies focusing on nuclear intermediate filament proteins called lamins were further continued as a junior group leader after returning back to Turku in early 2010. In 2011 PT received a specialist degree in Pathology and since then he has worked as a part-time specialist at the Pathology Division, Turku University Hospital with special focus on uropathology. From 2012 PT has worked as a Clinical lecturer in Pathology and between 2015-2019 as a part-time Academy of Finland Clinical Researcher. PT was appointed as a tenure track Assistant Professor of Molecular Pathology in January 2019 and an Associate Professor in August 2020. In January 2022, PT was appointed as a Professor of Molecular Pathology and he currently serves as the head of the pathology unit at the Faculty of Medicine, University of Turku.
Professor Pekka Taimen has 20 years of experience in cell and molecular biology as well as in translational research. The main focus of his research group is on human diseases caused by lamin mutations, such as cardiomyopathies and premature aging syndrome. More recently, PT has also actively worked on prostate and bladder cancer related projects including novel biomarkers, biobanking, patient derived cell lines and improved imaging techniques utilizing digital pathology and machine learning approaches.
Pekka Taimen has more than 10 years of experience in teaching medical students at the Institute of Biomedicine, University of Turku. He has served first as a university teacher and from 2012 as a clinical lecturer. In 2015 PT received the Lecturer of the Year award in the Faculty of Medicine.
- Palliative MRI-guided transurethral ultrasound ablation for symptomatic locally advanced prostate cancer (2020)
- Scandinavian Journal of Urology
(A1 Refereed original research article in a scientific journal) - Prediction of prostate cancer aggressiveness using 18 F-Fluciclovine (FACBC) PET and multisequence multiparametric MRI (2020)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Prognostic Role of Survivin and Macrophage Infiltration Quantified on Protein and mRNA Level in Molecular Subtypes Determined by RT-qPCR of KRT5, KRT20, and ERBB2 in Muscle-Invasive Bladder Cancer Treated by Adjuvant Chemotherapy (2020)
- International Journal of Molecular Sciences
(A1 Refereed original research article in a scientific journal) - Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB (2020)
- Human Molecular Genetics
(A1 Refereed original research article in a scientific journal) - Prostate Cancer Risk Stratification in Men With a Clinical Suspicion of Prostate Cancer Using a Unique Biparametric MRI and Expression of 11 Genes in Apparently Benign Tissue: Evaluation Using Machine-Learning Techniques (2020)
- Journal of Magnetic Resonance Imaging
(A1 Refereed original research article in a scientific journal) - Reply to Xuefeng Liu's Letter to the Editor, re: Kimmo Kettunen, Peter J. Bostrom, Tarja Lamminen, et al. Personalized Drug Sensitivity Screening for Bladder Cancer Using Conditionally Reprogrammed Patient-derived Cells. Eur Urol 2019;76:430-4: Can Patient-derived Cancer Models Change the Costliest Cancer Type? (2020)
- European Urology
(B1 Non-refereed article in a scientific journal) - Salvage Magnetic Resonance Imaging–guided Transurethral Ultrasound Ablation for Localized Radiorecurrent Prostate Cancer: 12-Month Functional and Oncological Results (2020)
- European Urology Open Science
(A1 Refereed original research article in a scientific journal) - ANO7 rs77559646 Is Associated With First-line Docetaxel Treatment Response in Metastatic Castration-resistant Prostate Cancer (2019)
- Anticancer Research
(A1 Refereed original research article in a scientific journal) - Clinical Utility of Mutant Antibody-Based Assays for Determination of Internally Cleaved and Intact Forms of Free Prostate-Specific Antigen (2019)
- The Journal of Applied Laboratory Medicine
(A1 Refereed original research article in a scientific journal) - Combined inhibition of tumor suppressors PTEN and PP2A drives anoikis resistance and is associated with therapy relapse in prostate cancer (2019)
- Cancer Research
(Other publication) - Correlation between 18F-1-amino-3-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) uptake and expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter 1 (LAT1) in primary prostate cancer (2019)
- EJNMMI Research
(A1 Refereed original research article in a scientific journal) - Feasibility of MRI-guided transurethral ultrasound for lesion-targeted ablation of prostate cancer (2019)
- Scandinavian Journal of Urology
(A1 Refereed original research article in a scientific journal) - Histopathological evaluation of prostate specimens after thermal ablation may be confounded by the presence of thermally-fixed cells (2019)
- International Journal of Hyperthermia
(A1 Refereed original research article in a scientific journal) - IMPROD biparametric MRI in men with a clinical suspicion of prostate cancer (IMPROD Trial): Sensitivity for prostate cancer detection in correlation with whole-mount prostatectomy sections and implications for focal therapy (2019)
- Journal of Magnetic Resonance Imaging
(A1 Refereed original research article in a scientific journal) - Lamiinikardiomyopatia (2019)
- Sydänääni: Suomen Kardiologisen Seuran Lehti
(D1 Article in a professional journal) - Modeling of LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells (2019)
- Cells
(A1 Refereed original research article in a scientific journal) - Personalized Drug Sensitivity Screening for Bladder Cancer Using Conditionally Reprogrammed Patient-derived Cells (2019)
- European Urology
(A1 Refereed original research article in a scientific journal) - Prebiopsy IMPROD Biparametric Magnetic Resonance Imaging Combined with Prostate-Specific Antigen Density in the Diagnosis of Prostate Cancer: An External Validation Study (2019)
- European Urology Oncology
(A1 Refereed original research article in a scientific journal) - Qualitative and Quantitative Reporting of a Unique Biparametric MRI: Towards Biparametric MRI-Based Nomograms for Prediction of Prostate Biopsy Outcome in Men With a Clinical Suspicion of Prostate Cancer (IMPROD and MULTI-IMPROD Trials) (2019)
- Journal of Magnetic Resonance Imaging
(A1 Refereed original research article in a scientific journal) - Quantitative Analysis of Nuclear Lamins Imaged by Super-Resolution Light Microscopy (2019)
- Cells
(B1 Non-refereed article in a scientific journal)