Juha Mykkänen
Dosentti (Adjunct professor)
cardiovascular and metabolic risk factors; metabolic disease; obesity; insulin resistance and type 2 diabetes; molecular genetics and genomics; metabolomics; transcriptomics; omics data analysis; statistics; type 1 diabetes; lysinuric protein intolerance; research project planning
EDUCATION AND DEGREES
2015 Adjunct professor (docent) of Molecular genetics, University of Turku (UTU)
2003 PhD, Medical genetics, UTU
1998 MSc, Genetics, UTU
CURRENT POSITION
Senior scientist, Research Centre of Applied and Preventive Cardiovascular Medicine, Medical Faculty, UTU
PAST POSITIONS
2009 – 2015 Senior scientist, Finnish Type 1 Diabetes Prediction and Prevention (DIPP) study, Department of Paediatrics and Adolescent Medicine, Turku University Hospital (TUH)
2005 – 2008 Academy of Finland Post-doctoral Researcher, Turku Centre for Biotechnology, UTU
2003 – 2008 Post-doctoral researcher, Turku Centre for Biotechnology, UTU
1998 – 2003 Post-graduate (PhD) training, Department of Medical Genetics, UTU
2000 – 2002 Part-time teacher, Department of Biology, UTU
1998 – 1999 Assistant (8 months), Department of Medical Genetics, UTU
1995 – 1997 Part-time research assistant, Department of Medical Genetics, UTU
I have dedicated my whole career on human health related research. This started already during my pre-graduate stage when I was working in Adjunct professor Jaana Lähdetie's research group at the Department of Medical Genetics (UTU) studying sperm aneuploidy of testicular cancer patients treated with radiotherapy. After my M.Sc., I familiarized with molecular genetics of hereditary diseases in children. In my doctoral dissertation I studied the molecular genetics of hereditary lysinuric protein intolerance (LPI) disease under the guidance Prof. emeritus of Pertti Aula at the Medical Genetics department. During this time I familiarized with various methods of human genomics and the so-called Finnish disease heritage.
During my post-doc studies, I moved to the Turku Centre for Biotechnology (UTU) to study the development of Type 1 diabetes as part of the Finnish DIPP study. During this time, I studied of Type 1 diabetes, molecular immunology and various genomic biomedical research methods such genome-wide microarrays. During the post-doc period I was a post-doctoral researcher of the Academy of Finland, the subject of the Molecular Markers of Type 1 diabetes, where biospecimens collected from DIPP children were analysed using various microarray platforms (in-house cDNA, Affymetrix and Illumina) in order to find genes or gene networks that change early in the course of Type 1 diabetes development.
The third phase of my research career began in 2009 as a senior researcher at the DIPP Research Clinic (Department of Paediatrics and Adolescent Medicine, TUH) led by Prof. emeritus Olli Simell. My research interest was to dissect and identify factors that modulate the risk for Type 1 diabetes related autoimmunity.
The fourth phase of my research career started in March 2015 as a senior researcher in The Cardiovascular Risk in Young Finns Study (YFS) coordinated by Academy Professor Olli Raitakari at the Research Centre of Applied and Preventive Cardiovascular Medicine (UTU), where risk factors for cardiovascular and metabolic diseases are studied in great detail. The main aim of my current research is to dissect the complex interplay of human genome, transcriptome and metabolome with risk factors of cardiovascular and metabolic diseases, both in cross-sectional and longitudinal settings, to increase our understanding of pathophysiology of cardiovascular and metabolic diseases.
Currently I supervise advanced studies or thesis in (bio)medicine.
- (2025)
- Scientific ReportsJournal of Clinical Endocrinology and Metabolism
Boelius, Hanna-Mari; Aatsinki, Anna-Katariina; Heiskanen, Marja A.; Haapala, Eero A.; Munukka, Eveliina; Mykkänen, Juha; Kartiosuo, Noora; Lahti, Leo; Keskitalo, Anniina; Huovinen, Pentti; Niinikoski, Harri; Viikari, Jorma; Rönnemaa, Tapani; Lagström, Hanna; Jula, Antti; Rovio, Suvi P.; Raitakari, Olli T.; Pahkala, Katja
- Blood pressure in childhood, young- and mid-adulthood: association with carotid plaque severity (2025) Meng, Yaxing; Koskinen, Juhani S.; Thomson, Russell; Juonala, Markus; Pahkala, Katja; Mykkanen, Juha; Rovio, Suvi P.; Kaehoenen, Mika; Lehtimaki, Terho; Viikari, Jorma S. A.; Raitakari, Olli T.; Magnussen, Costan G.
- Cardiometabolic determinants of aortic and carotid intima-media thickness in adolescence (2025) Laitinen, Tomi T.; Mikola, Hanna; Pahkala, Katja; Mykkänen, Juha; Rovio, Suvi P.; Niinikoski, Harri; Rönnemaa, Tapani; Viikari, Jorma S. A.; Jula, Antti; Lagström, Hanna; Salo, Pia; Nuotio, Joel; Ala-Korpela, Mika; Juonala, Markus; Magnussen, Costan G.; Raitakari, Olli T.
- Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study (2025)
- The Lancet healthy longevity
Heiskanen, Marja A; Mykkänen, Juha; Pahkala, Katja; Juonala, Markus; Kähönen, Mika; Lehtimäki, Terho; Laitinen, Tomi P; Jokinen, Eero; Tossavainen, Päivi; Linko-Parvinen, Anna; Pallari, Hanna-Mari; Blennow, Kaj; Zetterberg, Henrik; Viikari, Jorma; Raitakari, Olli; Rovio, Suvi P
- Polygenic prediction of body mass index and obesity through the life course and across ancestriesRandomized 20-year infancy-onset dietary intervention, life-long cardiovascular risk factors and retinal microvasculature2025
- Nature MedicineEuropean Heart Journal
Smit Roelof A. J.; Wade Kaitlin H.; Hui Qin; Arias Joshua D.; Yin Xianyong; Christiansen Malene R.; Yengo Loic; Preuss Michael H.; Nakabuye Mariam; Rocheleau Ghislain; Graham Sarah E.; Buchanan Victoria L.; Chittoor Geetha; Graff Marielisa; Guindo-Martínez Marta; Lu Yingchang; Marouli Eirini; Sakaue Saori; Spracklen Cassandra N.; Vedantam Sailaja; Wilson Emma P.; Chen Shyh-Huei; Ferreira Teresa; Ji Yingjie; Karaderi Tugce; Lüll Kreete; Machado Moara; Malden Deborah E.; Medina-Gomez Carolina; Moore Amy; Rüeger Sina; Akiyama Masato; Allison Matthew A.; Alvarez Marcus; Andersen Mette K.; Appadurai Vivek; Arbeeva Liubov; Bartell Eric; Bhaskar Seema; Bielak Lawrence F.; Bis Joshua C.; Bollepalli Sailalitha; Bork-Jensen Jette; Bradfield Jonathan P.; Bradford Yuki; Brandl Caroline; Braund Peter S.; Brody Jennifer A.; Broeckel Ulrich; Burgdorf Kristoffer S.; Cade Brian E.; Cai Qiuyin; Camarda Silvia; Campbell Archie; Cañadas-Garre Marisa; Chai Jin-Fang; Chesi Alessandra; Choi Seung Hoan; Christofidou Paraskevi; Couture Christian; Cuellar-Partida Gabriel; Danning Rebecca; Degenhardt Frauke; Delgado Graciela E.; Delitala Alessandro; Demirkan Ayşe; Deng Xuan; Dietl Alexander; Dimitriou Maria; Dimitrov Latchezar; Dorajoo Rajkumar; Eichelmann Fabian; Eliasen Anders U.; Engmann Jorgen E.; Erdos Michael R.; Fairhurst-Hunter Zammy; Farmaki Aliki-Eleni; Faul Jessica D.; Fernandez-Lopez Juan-Carlos; Forer Lukas; Frank Mirjam; Freitag-Wolf Sandra; Fritsche Lars G.; Fuchsberger Christian; Galesloot Tessel E.; Gao Yan; Geller Frank; Giannakopoulou Olga; Giulianini Franco; Gjesing Anette P.; Goel Anuj; Gordon Scott D.; Gorski Mathias; Grove Jakob; Guo Xiuqing; Gustafsson Stefan; Haessler Jeffrey; Hansen Thomas F.; Havulinna Aki S.; Haworth Simon J.; Heard-Costa Nancy; Hemerich Daiane; Highland Heather M.; Hindy George; Ho Yuk-Lam; Hofer Edith; Holliday Elizabeth; Horn Katrin; Hornsby Whitney E.; Hottenga Jouke-Jan; Huang Hongyan; Huang Jie; Huerta-Chagoya Alicia; Huo Shaofeng; Hwang Mi Yeong; Hwu Chii-Min; Iha Hiroyuki; Ikeda Daisuke D.; Isono Masato; Jackson Anne U.; Jansen Iris E.; Jiang Yunxuan; Johansson Ingegerd; Jonsson Anna; Jørgensen Torben; Kalafati Ioanna P.; Kanai Masahiro; Kanoni Stavroula; Kårhus Line L.; Kasturiratne Anuradhani; Katsuya Tomohiro; Kawaguchi Takahisa; Kember Rachel L.; Kentistou Katherine A.; Kim Daeeun; Kim Han-Na; Kim Young Jin; Kleber Marcus E.; Knol Maria J.; Kurbasic Azra; Lauzon Marie; Le Phuong; Lea Rodney; Lee Jong-Young; Lee Wen-Jane; Leonard Hampton L.; Li Hengtong; Li Shengchao A.; Li Xiaohui; Li Xiaoyin; Liang Jingjing; Lin Honghuang; Lin Kuang; Liu Jun; Liu Xueping; Lo Ken Sin; Long Jirong; Lores-Motta Laura; Luan Jian’an; Lyssenko Valeriya; Lyytikäinen Leo-Pekka; Mahajan Anubha; Malik Md Zubbair; Mamakou Vasiliki; Mangino Massimo; Manichaikul Ani; Marten Jonathan; Mattheisen Manuel; McDaid Aaron F.; Mei Quanshun; Meiselbach Heike; Melendez Tori L.; Milaneschi Yuri; Miller Jason E.; Millwood Iona Y.; Mishra Pashupati P.; Mitchell Ruth E.; Møllehave Line T.; Mononen Nina; Mucha Sören; Munz Matthias; Mykkänen Juha; Nakatochi Masahiro; Nardone Giuseppe Giovanni; Nelson Christopher P.; Nethander Maria; Nho Chu Won; Nielsen Aneta A.; Nolte Ilja M.; Nongmaithem Suraj S.; Noordam Raymond; Ntalla Ioanna; Nutile Teresa; Pandit Anita; Pauper Marc; Petersen Eva R. 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Gustav; Snieder Harold; Spector Tim D.; Spedicati Beatrice; Stampfer Meir J.; Stark Klaus J.; Strachan David P.; Tabara Yasuharu; Tai E. Shyong; Tang Hua; Tardif Jean-Claude; Thanaraj Thangavel A.; Tönjes Anke; Tuomi Tiinamaija; Tuomilehto Jaakko; Tusié-Luna Maria-Teresa; van Dam Rob M.; van der Harst Pim; Van der Velde Nathalie; van Duijn Cornelia M.; van Schoor Natasja M.; Vitart Veronique; Vohl Marie-Claude; Völker Uwe; Vollenweider Peter; Völzke Henry; Vrieze Scott; Wacher-Rodarte Niels H.; Walker Mark; Wander Gurpreet S.; Wareham Nicholas J.; Watanabe Richard M.; Watkins Hugh; Weir David R.; Werge Thomas M.; Widen Elisabeth; Willemsen Gonneke; Willett Walter C.; Wilson James F.; Wilson Peter W. F.; Wong Tien Y.; Woo Jeong-Taek; Wright Alan F.; Xu Huichun; Yajnik Chittaranjan S.; Yang Jian; Yokota Mitsuhiro; Yuan Jian-Min; Zeggini Eleftheria; Zemel Babette S.; Zheng Wei; Zhu Xiaofeng; Zillikens M. Carola; Zonderman Alan B.; Zwart John-Anker; {name=23andMe Research Team, sequence=additional, affiliation=[]}; {name=DiscovEHR (DiscovEHR and MyCode Community Health Initiative), sequence=additional, affiliation=[]}; {name=eMERGE (Electronic Medical Records and Genomics Network), sequence=additional, affiliation=[]}; {name=GPC-UGR, sequence=additional, affiliation=[]}; {name=The PRACTICAL Consortium, sequence=additional, affiliation=[]}; {name=Understanding Society Scientific Group, sequence=additional, affiliation=[]}; {name=VA Million Veteran Program, sequence=additional, affiliation=[]}; Abecasis Goncalo R.; Assimes Themistocles L.; Auton Adam; Boehnke Michael; Chasman Daniel I.; Esko Tõnu; Stefansson Kari; Lettre Guillaume; Lindgren Cecilia M.; Ng Maggie C. Y.; O’Donnell Christopher J.; Thorsteinsdottir Unnur; Visscher Peter M.; Walters Robin G.; Winkler Thomas W.; Wood Andrew R.; Deloukas Panos; Frayling Timothy M.; Justice Anne E.; Kilpeläinen Tuomas O.; Locke Adam E.; Mohlke Karen L.; North Kari E.; Okada Yukinori; Willer Cristen J.; Young Kristin L.; Fatumo Segun; McCaffery Jeanne M.; Timpson Nicholas J.; Hirschhorn Joel N.; Sun Yan V.; Berndt Sonja I.; Loos Ruth J. F.
- Prevalence of carotid atherosclerosis in 3-92-year-old Finns. The 3-generational cardiovascular risk in young Finns study (2025)
- AtherosclerosisAtherosclerosis
Raitakari, Olli T.; Koskinen, Juhani S.; Pahkala, Katja; Rovio, Suvi; Mykkänen, Juha; Kartiosuo, Noora; Stenbacka, Sini; Lisinen, Irina; Loo, Britt-Marie; Lehtimäki, Terho; Kähönen, Mika; Juonala, Markus; Laitinen, Tomi P.; Jokinen, Eero; Kaikkonen, Jari; Tossavainen, Päivi; Viikari, Jorma S.A.
- The effect of polychlorinated biphenyls on type 2 diabetes risk is mediated via DNA methylation (2025)
- Environment InternationalJournal of the American Heart Association
Kartiosuo, Noora; Auranen, Kari; Mansell, Toby; Novakovic, Boris; Nevalainen, Jaakko; Pahkala, Katja; Rovio, Suvi; Mykkänen, Juha; Viikari, Jorma; Juonala, Markus; Rantakokko, Panu; Kiviranta, Hannu; Kaikkonen, Jari; Lehtimäki, Terho; Raitoharju, Emma; Mishra, Pashupati P.; Kähönen, Mika; Ponsonby, Anne-Louise; Tanner, Sam; Burgner, David; Raitakari, Olli; Saffery, Richard
- Association of Serum Trimethylamine-N-Oxide Concentration from Childhood to Early Adulthood with Age and Sex (2024) Almer, Gunter; Enko, Dietmar; Kartiosuo, Noora; Niinikoski, Harri; Lehtimäki, Terho; Munukka, Eveliina; Viikari, Jorma; Rönnemaa, Tapani; Rovio, Suvi P; Mykkänen, Juha; Lagström, Hanna; Jula, Antti; Herrmann, Markus; Raitakari, Olli T; Meinitzer, Andreas; Pahkala, Katja
- Associations of Cumulative Adulthood, Childhood and Lifelong Insulin With Adulthood Retinal Microvasculature (2024) Repo, Oskari; Juonala, Markus; Rovio, Suvi P.; Mykkänen, Juha; Nevalainen, Jaakko; Kähönen, Mika; Lehtimäki, Terho; Laitinen, Tomi P.; Viikari, Jorma; Raitakari, Olli; Tapp, Robyn; Pahkala, Katja
- Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis (2024) Takaoka, M; Zhao, X; Lim, HY, Magnussen, CG; Ang, O; Suffee, N; Schrank, PR; Ong, WS; Tsiantoulas, D; Sommer, F; Mohanta, SK; Harrison, J; Meng, Y; Laurans, L; Wu, F; Lu, Y; Masters, L; Newland, SA; Denti, L; Hong, M; Chajadine, M; Juonala, M; Koskinen, JS; Kähönen, M; Pahkala, K; Rovio, SP; Mykkänen, J; Thomson, R; Kaisho, T; Habenicht, AJR; Clement, M; Tedgui, A; Ait-Oufella, H; Zhao, TX; Nus, M; Ruhrberg, C; Taleb, S; Williams, JW; Raitakari, OT; Angeli, V; Mallat, Z
- Exploring machine learning strategies for predicting cardiovascular disease risk factors from multi-omic data (2024)
- BMC Medical Informatics and Decision Making
Drouard Gabin, Mykkänen Juha, Heiskanen Jarkko, Pohjonen Joona, Ruohonen Saku, Pahkala Katja, Lehtimäki Terho, Wang Xiaoling, Ollikainen Miina, Ripatti Samuli, Pirinen Matti, Raitakari Olli, Kaprio Jaakko
- (2024) Repo, Oskari; Juonala, Markus; Niinikoski, Harri; Rovio, Suvi; Mykkänen, Juha; Lagström, Hanna; Cheung, Carol Y; Yang, Dawei; Vaahtoranta-Lehtonen, Hanna; Jula, Antti; Nevalainen, Jaakko; Rönnemaa, Tapani; Viikari, Jorma; Raitakari, Olli; Tapp, Robyn; Pahkala, Katja
- Subclinical atherosclerosis in young adults predicting cardiovascular disease : The cardiovascular risk in young Finns study (2024) Raitakari Olli T., Magnussen Costan G., Juonala Markus, Kartiosuo Noora, Pahkala Katja, Rovio Suvi, Koskinen Juhani S., Mykkänen Juha, Laitinen Tomi P., Kähönen Mika, Nuotio Joel, Viikari Jorma S.A.
- Glycoprotein Acetyls: A Novel Inflammatory Biomarker of Early Cardiovascular Risk in the Young (2022) Chiesa Scott T., Charakida Marietta, Georgiopoulos Georgios, Roberts Justin D., Stafford Simon J., Park Chloe, Mykkänen Juha, Kähönen Mika, Lehtimäki Terho, Ala‐Korpela Mika, Raitakari Olli, Pietiäinen Milla, Pussinen Pirkko, Muthurangu Vivek, Hughes Alun D., Sattar Naveed, Timpson Nicholas J., Deanfield John E.
- Long-term tracking and population characteristics of lipoprotein (a) in the Cardiovascular Risk in Young Finns Study (2022) Raitakari Olli, Kivelä Annukka, Pahkala Katja, Rovio Suvi, Mykkänen Juha, Ahola-Olli Ari, Loo Britt-Marie, Lyytikäinen Leo-Pekka, Lehtimäki Terho, Kähönen Mika, Juonala Markus, Rönnemaa Tapani, Lamina Claudia, Kronenberg Florian, Viikari Jorma
- Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values (2022) Drouard Gabin, Ollikainen Miina, Mykkänen Juha, Raitakari Olli, Lehtimaki Terho, Kähönen Mika, Mishra Pashupati P, Wang Xiaoling L, Kaprio Jaakko
- Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples (2022) Laajala Essi, Halla-Aho Viivi, Grönroos Toni, Kalim Ubaid Ullah, Vähä-Mäkilä Mari, Nurmio Mirja, Kallionpää Henna, Lietzén Niina, Mykkänen Juha, Rasool Omid, Toppari Jorma, Oresic Matej, Knip Mikael, Lund Riikka, Lahesmaa Riitta, Lähdesmäki Harri
- Type 1 Diabetes in Children With Genetic Risk May Be Predicted Very Early With a Blood miRNA (2022) Suomi Tomi, Kalim Ubaid Ullah, Rasool Omid, Laiho Asta, Kallionpää Henna, Vähä-Mäkilä Mari, Nurmio Mirja, Mykkänen Juha, Härkönen Taina, Hyöty Heikki, Ilonen Jorma, Veijola Riitta, Toppari Jorma, Knip Mikael, Elo Laura L, Lahesmaa Riitta
- Umbilical cord blood DNA methylation in children who later develop type 1 diabetes (2022) Laajala Essi, Kalim Ubaid U, Grönroos Toni, Rasool Omid, Halla-aho Viivi, Konki Mikko, Kattelus Roosa, Mykkänen Juha, Nurmio Mirja, Vähä-Mäkilä Mari, Kallionpää Henna, Lietzen Niina, Ghimire Bishwa R, Laiho Asta, Hyöty Heikki, Elo Laura L, Ilonen Jorma, Knip Mikael, Lund Riikka J, Orešič Matej, Veijola Riitta, Lähdesmäki Harri, Toppari Jorma, Lahesmaa Riitta
- Childhood exposure to parental smoking and life-course overweight and central obesity (2021) Jaakkola Johanna M, Rovio Suvi P, Pahkala Katja, Viikari Jorma, Rönnemaa Tapani, Jula Antti, Niinikoski Harri, Mykkänen Juha, Juonala Markus, Hutri-Kähönen Nina, Kähönen Mika, Lehtimäki Terho, Raitakari Olli T
