Markus Juonala
Professor
mataju@utu.fi +358 29 450 2754 +358 50 478 3572 |
Internal medicine; endocrinology; cardiovascular risk
Cardiovascular epidemiology, Young Finns Study, i3c consortium
Professor Markus Juonala (MD,
PhD, University of Turku) is a specialist in internal medicine and
endocrinology at the Turku University Hospital, Turku, Finland. Since 2001, he
has been conducting research on longitudinal studies examining the importance
of childhood risk factors on later cardiovascular health. His PhD work was
based primarily on the Cardiovascular Risk in Young Finns Study (University of
Turku, April 2005). Since 2008, he has had a major involvement in the
development of the International Childhood Cardiovascular Cohort (i3C)
Consortium that combines the efforts of the main longitudinal studies
worldwide. In June 2014, he was appointed as Professor of Internal Medicine at
the University of Turku. In 2014-2015 and 2018-2019 he has been working as the Dame Elisabeth Murdoch Fellow in Murdoch Childrens Research Institute
(MCRI).
His career
publications total is 270 (h-index 44) with published highlights including a
first-author paper in the New England Journal of Medicine, the first-ranked
general medicine journal, one paper in JAMA, the third-ranked general medicine
journal and 30 papers (11 as first/last author) published in either the number
one, two, or three ranked cardiovascular disease journals (17 in Circulation,
five in the Journal of the American College of Cardiology, eight in the
European Heart Journal).
Professor Juonala’s
principal research focus has been to provide novel information on the effects
of childhood risk factors on cardiovascular health in adulthood. Beginning from
the summer of 2008 he has led a research group within the Young Finns Study and
i3c consortium with special interest on cardiometabolic risk factors. The most
important findings of his research have provided information on childhood and
early adulthood risk factors for atherosclerosis, suggesting that childhood
risk factors, such as dyslipidaemia, elevated blood pressure and smoking,
predict early atherosclerosis and its progression independent of adult risk
factors levels. Concerning cardiometabolic risk factors, his group has been
able to show that overweight and metabolic syndrome diagnosed either in childhood or adulthood
is predictive of carotid atherosclerosis and its progression in adulthood.
However, at the time of obesity epidemic, the most important findings concern
the reversibility of cardiovascular risk. His work has demonstrated that although overweight and metabolic syndrome are predictive of early atherosclerosis, favourable changes
in lifestyle associated with weight maintenance or reduction improve
cardiovascular health.
Teaching responsibilities: 1) Internal medicine for medical students, 2) Internal medicine specialisation programme for MDs
Special interest areas: Acute internal medicine, endocrinology, lipidology
- HDL cholesterol efflux capacity is inversely associated with subclinical cardiovascular risk markers in young adults: The cardiovascular risk in Young Finns study (2020)
- Scientific Reports
- HIF3A cord blood methylation and systolic blood pressure at 4 years - a population-based cohort study (2020)
- Epigenetics
- Ideal cardiovascular health in adolescents and young adults is associated with alexithymia over two decades later: Findings from the cardiovascular risk in Young Finns Study (2020)
- Psychiatry Research
- Inflammation mediates the relationship between obesity and retinal vascular calibre in 11-12 year-olds children and mid-life adults (2020)
- Scientific Reports
- Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells (2020)
- Nature
- Lipidomic architecture shared by subclinical markers of osteoporosis and atherosclerosis: The Cardiovascular Risk in Young Finns Study (2020)
- BONE
- Longitudinal association of a body mass index (BMI) genetic risk score with growth and BMI changes across the life course: The Cardiovascular Risk in Young Finns Study (2020)
- International Journal of Obesity
- Lower grip strength in youth with obesity identifies those with increased cardiometabolic risk (2020)
- Obesity Research and Clinical Practice
- Non-HDL Cholesterol Levels in Childhood and Carotid Intima-Media Thickness in Adulthood (2020)
- Pediatrics
- Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers (2020)
- Nature Medicine
- Polygenic Hyperlipidemias and Coronary Artery Disease Risk (2020)
- Circulation: Genomic and Precision Medicine
- Prediction of adult class II/III obesity from childhood BMI: the i3C consortium (2020)
- International Journal of Obesity
- Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma (2020)
- PLoS Genetics
- Sepelvaltimotaudin primaari- ja sekundaariprevention tilanne Suomessa (2020)
- Sydänääni: Suomen Kardiologisen Seuran Lehti
- Socioeconomic status, remoteness and tracking of nutritional status from childhood to adulthood in an Australian Aboriginal Birth Cohort: the ABC study (2020)
- BMJ Open
- Systemic vascular resistance predicts the development of hypertension: the cardiovascular risk in young Finns study (2020)
- Blood Pressure
- The associations of physical activity and physical capability with cardiovascular health among working-age finnish women (2020)
- Translational sports medicine
- The "Goldilocks Day" for Children's Skeletal Health: Compositional Data Analysis of 24-Hour Activity Behaviors (2020)
- Journal of Bone and Mineral Research
- The role of polygenic risk and susceptibility genes in breast cancer over the course of life (2020)
- Nature Communications
- Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan (2020)
- Nature Medicine