Markus Juonala
Professor
mataju@utu.fi +358 29 450 2754 +358 50 478 3572 |
Internal medicine; endocrinology; cardiovascular risk
Cardiovascular epidemiology, Young Finns Study, i3c consortium
Professor Markus Juonala (MD,
PhD, University of Turku) is a specialist in internal medicine and
endocrinology at the Turku University Hospital, Turku, Finland. Since 2001, he
has been conducting research on longitudinal studies examining the importance
of childhood risk factors on later cardiovascular health. His PhD work was
based primarily on the Cardiovascular Risk in Young Finns Study (University of
Turku, April 2005). Since 2008, he has had a major involvement in the
development of the International Childhood Cardiovascular Cohort (i3C)
Consortium that combines the efforts of the main longitudinal studies
worldwide. In June 2014, he was appointed as Professor of Internal Medicine at
the University of Turku. In 2014-2015 and 2018-2019 he has been working as the Dame Elisabeth Murdoch Fellow in Murdoch Childrens Research Institute
(MCRI).
His career
publications total is 270 (h-index 44) with published highlights including a
first-author paper in the New England Journal of Medicine, the first-ranked
general medicine journal, one paper in JAMA, the third-ranked general medicine
journal and 30 papers (11 as first/last author) published in either the number
one, two, or three ranked cardiovascular disease journals (17 in Circulation,
five in the Journal of the American College of Cardiology, eight in the
European Heart Journal).
Professor Juonala’s
principal research focus has been to provide novel information on the effects
of childhood risk factors on cardiovascular health in adulthood. Beginning from
the summer of 2008 he has led a research group within the Young Finns Study and
i3c consortium with special interest on cardiometabolic risk factors. The most
important findings of his research have provided information on childhood and
early adulthood risk factors for atherosclerosis, suggesting that childhood
risk factors, such as dyslipidaemia, elevated blood pressure and smoking,
predict early atherosclerosis and its progression independent of adult risk
factors levels. Concerning cardiometabolic risk factors, his group has been
able to show that overweight and metabolic syndrome diagnosed either in childhood or adulthood
is predictive of carotid atherosclerosis and its progression in adulthood.
However, at the time of obesity epidemic, the most important findings concern
the reversibility of cardiovascular risk. His work has demonstrated that although overweight and metabolic syndrome are predictive of early atherosclerosis, favourable changes
in lifestyle associated with weight maintenance or reduction improve
cardiovascular health.
Teaching responsibilities: 1) Internal medicine for medical students, 2) Internal medicine specialisation programme for MDs
Special interest areas: Acute internal medicine, endocrinology, lipidology
- Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs (2021)
- Clinical Epigenetics
- Modest decrease in severity of obesity in adolescence associates with low arterial stiffness (2021)
- Atherosclerosis
- Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study (2021)
- Scientific Reports
- Physical inactivity from youth to adulthood and adult cardiometabolic risk profile (2021)
- Preventive Medicine
- Sleep and cardiometabolic health in children and adults: examining sleep as a component of the 24-h day (2021)
- Sleep Medicine
- Sleep and cardiometabolic risk: a cluster analysis of actigraphy-derived sleep profiles in adults and children (2021)
- Sleep
- Takeaway food, sugar-sweetened beverages and preclinical cardiometabolic phenotypes in children and adults (2021)
- European Journal of Preventive Cardiology
- The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions. The Cardiovascular Risk in Young Finns Study (2021)
- Free Radical Biology and Medicine
- The Timing and Sequence of Cardiovascular Health Decline (2021)
- American Journal of Preventive Medicine
- Toe pressure and toe brachial index are predictive of cardiovascular mortality regardless of the most diseased arterial segment in symptomatic lower-extremity artery disease—A retrospective cohort study (2021)
- PLoS ONE
- Uncovering the shared lipidomic markers of subclinical osteoporosis-atherosclerosis comorbidity: The Young Finns Study (2021)
- BONE
- Weight change from childhood to adulthood and cardiovascular risk factors and outcomes in adulthood: A systematic review of the literature (2021)
- Obesity Reviews
- Within-visit SBP variability from childhood to adulthood and markers of cardiovascular end-organ damage in mid-life (2021)
- Journal of Hypertension
- Age-Specific Estimates and Comparisons of Youth Tri-Ponderal Mass Index and Body Mass Index in Predicting Adult Obesity-Related Outcomes (2020)
- Journal of Pediatrics
- American Heart Association ideal cardiovascular health score and subclinical atherosclerosis in 22-35-year-old adults conceived with and without assisted reproductive technologies (2020)
- Human Reproduction
- A network approach to the analysis of psychosocial risk factors and their association with health (2020)
- Journal of Health Psychology
- A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling (2020)
- American Journal of Human Genetics
- Association of Body Mass Index in Youth With Adult Cardiometabolic Risk (2020)
- Journal of the American Heart Association
- Association of brachial-cuff excess pressure with carotid intima-media thickness in Australian adults: a cross-sectional study (2020)
- Journal of Hypertension
- Associations of retinal microvascular caliber with large arterial function and structure: A population-based study of 11 to 12 year-olds and midlife adults (2020)
- Microcirculation