Markus Juonala
Professor
mataju@utu.fi +358 29 450 2754 +358 50 478 3572 |
Internal medicine; endocrinology; cardiovascular risk
Cardiovascular epidemiology, Young Finns Study, i3c consortium
Professor Markus Juonala (MD,
PhD, University of Turku) is a specialist in internal medicine and
endocrinology at the Turku University Hospital, Turku, Finland. Since 2001, he
has been conducting research on longitudinal studies examining the importance
of childhood risk factors on later cardiovascular health. His PhD work was
based primarily on the Cardiovascular Risk in Young Finns Study (University of
Turku, April 2005). Since 2008, he has had a major involvement in the
development of the International Childhood Cardiovascular Cohort (i3C)
Consortium that combines the efforts of the main longitudinal studies
worldwide. In June 2014, he was appointed as Professor of Internal Medicine at
the University of Turku. In 2014-2015 and 2018-2019 he has been working as the Dame Elisabeth Murdoch Fellow in Murdoch Childrens Research Institute
(MCRI).
His career
publications total is 270 (h-index 44) with published highlights including a
first-author paper in the New England Journal of Medicine, the first-ranked
general medicine journal, one paper in JAMA, the third-ranked general medicine
journal and 30 papers (11 as first/last author) published in either the number
one, two, or three ranked cardiovascular disease journals (17 in Circulation,
five in the Journal of the American College of Cardiology, eight in the
European Heart Journal).
Professor Juonala’s
principal research focus has been to provide novel information on the effects
of childhood risk factors on cardiovascular health in adulthood. Beginning from
the summer of 2008 he has led a research group within the Young Finns Study and
i3c consortium with special interest on cardiometabolic risk factors. The most
important findings of his research have provided information on childhood and
early adulthood risk factors for atherosclerosis, suggesting that childhood
risk factors, such as dyslipidaemia, elevated blood pressure and smoking,
predict early atherosclerosis and its progression independent of adult risk
factors levels. Concerning cardiometabolic risk factors, his group has been
able to show that overweight and metabolic syndrome diagnosed either in childhood or adulthood
is predictive of carotid atherosclerosis and its progression in adulthood.
However, at the time of obesity epidemic, the most important findings concern
the reversibility of cardiovascular risk. His work has demonstrated that although overweight and metabolic syndrome are predictive of early atherosclerosis, favourable changes
in lifestyle associated with weight maintenance or reduction improve
cardiovascular health.
Teaching responsibilities: 1) Internal medicine for medical students, 2) Internal medicine specialisation programme for MDs
Special interest areas: Acute internal medicine, endocrinology, lipidology
- Low childhood high density lipoprotein cholesterol levels and subsequent risk for chronic inflammatory bowel disease (2018)
- Digestive and Liver Disease
- Neighbourhood socioeconomic disadvantage, risk factors, and diabetes from childhood to middle age in the Young Finns Study: a cohort study (2018)
- Lancet Public Health
- Physical Inactivity from Youth to Adulthood and Risk of Impaired Glucose Metabolism (2018)
- Medicine and Science in Sports and Exercise
- Pulse Wave Velocity Predicts the Progression of Blood Pressure and Development of Hypertension in Young Adults (2018)
- Hypertension
- Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis (2018)
- Scientific Reports
- Success in Achieving the Targets of the 20-Year Infancy-Onset Dietary Intervention: Association With Insulin Sensitivity and Serum Lipids (2018)
- Diabetes Care
- The International Childhood Cardiovascular Cohort (i3C) consortium outcomes study of childhood cardiovascular risk factors and adult cardiovascular morbidity and mortality: Design and recruitment (2018)
- Contemporary Clinical Trials
- Accumulation of Depressive Symptoms and Carotid Intima-Media Thickness: the Cardiovascular Risk in Young Finns Study (2017)
- Annals of Behavioral Medicine
- An interaction map of circulating metabolites, immune gene networks, and their genetic regulation (2017)
- Genome Biology
- Association of Socioeconomic Status in Childhood With Left Ventricular Structure and Diastolic Function in Adulthood The Cardiovascular Risk in Young Finns Study (2017)
- JAMA Pediatrics
- Bayesian hierarchical piecewise regression models: a tool to detect trajectory divergence between groups in long-term observational studies (2017)
- BMC Medical Research Methodology
- Blood pathway analyses reveal differences between prediabetic subjects with or without dyslipidaemia. The Cardiovascular Risk in Young Finns Study (2017)
- Diabetes/Metabolism Research and Reviews
- Cardiometabolic Determinants of Carotid and Aortic Distensibility From Childhood to Early Adulthood (2017)
- Hypertension
- Cardiorespiratory Fitness and Risk of Fatty Liver: The Young Finns Study (2017)
- Medicine and Science in Sports and Exercise
- Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance The Young Finns Study (2017)
- Journal of the American College of Cardiology
- Childhood age and associations between childhood metabolic syndrome and adult risk for metabolic syndrome, type 2 diabetes mellitus and carotid intima media thickness: The international childhood cardiovascular cohort consortium (2017)
- Journal of the American Heart Association
- Childhood Socioeconomic Status and Arterial Stiffness in Adulthood The Cardiovascular Risk in Young Finns Study (2017)
- Hypertension
- Clinical review of 24-35 year olds conceived with and without in vitro fertilization: study protocol (2017)
- Reproductive Health
- Does high optimism protect against the inter-generational transmission of high BMI? The Cardiovascular Risk in Young Finns Study (2017)
- Journal of Psychosomatic Research
- Exposure to Parental Smoking in Childhood is Associated with High C-Reactive Protein in Adulthood: The Cardiovascular Risk in Young Finns Study (2017)
- Journal of Atherosclerosis and Thrombosis