Jatta Helin
Senior Researcher, Laboratory operations and compliance manager
Drug development; translational in vivo research; molecular imaging; positron emission tomography; radiopharmacokinetics; receptor binding; kinetic analysis; compartment modelling; ADME
Quantitative kinetic modeling of small animal PET imaging data
The main goal of our research is to provide quantitative modeling tools that enable kinetic analyses of animal PET imaging data. Tracer kinetic models can be exploited to measure blood flow, membrane transport, metabolism, and ligand-receptor interactions noninvasively and quantitatively in various animal disease models tailored for metabolic disorders, and neurodegenerative and neuropsychiatric diseases. Ongoing projects aim at translating preclinically achieved data into human PET imaging protocols to be used in research and clinical settings.
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- (2025)
- Journal of Imaging Informatics in MedicineFrontiers in Endocrinology
- Correction to: Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA (EJNMMI Research, (2024), 14, 1, (25), 10.1186/s13550-024-01085-7) (2024)
- EJNMMI Research
- Evaluation of bone marrow glucose uptake and adiposity in male rats after diet and exercise interventions (2024)
- Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA (2024)
- EJNMMI Research
- In-target production of [11C]CH4 from a nitrogen/hydrogen gas target as a function of beam current, irradiation time, and target temperature (2024)
- EJNMMI Radiopharmacy and Chemistry
- 2024
- Journal of Functional Morphology and KinesiologyMolecular Imaging and Biology
- (2023)
- International Journal of Biomedical ImagingJournal of Cerebral Blood Flow and Metabolism
- Direct Comparison of [18F]F-DPA with [18F]DPA-714 and [11C]PBR28 for Neuroinflammation Imaging in the same Alzheimer’s Disease Model Mice and Healthy Controls (2022)
- (S)-[18F]THK5117 brain uptake is associated with Aβ plaques and MAO-B enzyme in a mouse model of Alzheimer's disease (2021)
- Neuropharmacology
- Comparison of high and low molar activity TSPO tracer [18F]F-DPA in a mouse model of Alzheimer’s disease (2020)
- Ruthenium-Mediated 18F-Fluorination and Preclinical Evaluation of a New CB1 Receptor Imaging Agent [18F]FPATPP (2020)
- ACS Chemical Neuroscience
- Effect of genotype and age on cerebral [F-18]FDG uptake varies between transgenic APP(swe)-PS1(dE9) and Tg2576 mouse models of Alzheimer's disease (2019)
- Scientific Reports
- Imaging glucose metabolism, neuroinflammation, and cannabinoid receptor 1 in transgenic mouse models of Alzheimer’s disease (2019) Takkinen Jatta
- In vivo characterization of a novel norepinephrine transporter PET tracer [18F]NS12137 in adult and immature Sprague-Dawley rats (2019)
- Theranostics
- Radiosynthesis and Preclinical Evaluation of an α2A-Adrenoceptor Tracer Candidate, 6-[18F]Fluoro-marsanidine (2019)
- Molecular Imaging and Biology
- [18F]F-DPA for the detection of activated microglia in a mouse model of Alzheimer's disease (2018)
- Nuclear Medicine and Biology
- 18F-labeled norepinephrine transporter tracer [18F]NS12137: radiosynthesis and preclinical evaluation (2018)
- Nuclear Medicine and Biology
- [F-18]FMPEP-d(2) PET imaging shows age- and genotype-dependent impairments in the availability of cannabinoid receptor 1 in a mouse model of Alzheimer's disease (2018)
- Neurobiology of Aging
- Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18F-FDG and 18F-DPA-714 PET imaging (2017)
- Journal of Cerebral Blood Flow and Metabolism
- Radiosynthesis and Preclinical Evaluation of [F-18]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats (2017)
- Molecular Imaging and Biology
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