Noora Kotaja
PhD, Professor of Molecular Medicine
nookot@utu.fi +358 29 450 4639 +358 50 477 3367 Kiinamyllynkatu 10 Turku Työhuone: C539 ORCID-tunniste: https://orcid.org/0000-0003-1503-9170 |
Hedelmällisyys, spermatogeneesi, sukusolut, geenisäätely, RNA-säätely, ei-koodaavat RNA:t, epigeneettinen periytyminen
RNA-säätely miesten sukusoluissa
Noora Kotaja is a Professor of Molecular
Medicine at the Institute of Biomedicine, University of Turku, Finland. She
obtained PhD in Biomedicine at the University of Helsinki under supervision of
Profs. Olli Jänne and Jorma Palvimo. The title of her PhD thesis was
"Function of PIAS proteins in steroid receptor-dependent signaling" ,
and it was approved with distinction and awarded with PhD theseis award from
the Finnish Academy of Science.She did her postdoctoral training at the
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg,
France, in the research group of Dr. Paolo Sassone-Corsi on germ cell-specific
regulation of gene expression. In 2006, she returned back in Finland to
establish her own research group at the University of Turku, where she received
first an Academy Research Fellow post from the Academy of Finland, followed by
a tenure track Professor position in 2012. Her scientific achievements have
been recognized by L'Oreal Finland for Women in Science award in 2006, Unto
Uotila award form the Finnish Endrocrine Society in 2008 and Young Researcher
award from the International Netwolrk of Young Researchers in Male Fertiliy in
2011 and Yourn Andrologist award from the International Society of Andrology in
2013.
Noora Kotaja's research focuses on the mechanisms of spermatogenesis and
germline-mediated epigenetic inheritance. In particular, her research group is
interested in the epigenetic and posttranscriptional regulation of gene
expression in meiotic and post-meiotic male germ cells, and the role of large
germ cell-specific ribonucleoprotein granules (germ granules) in the control of
germ cell's transcriptome. The research in the Kotaja group combines experimental animal studies
with human cohort studies to elucidate key epigenetic processes required for
the production of fertile spermatozoa and correct transgenerational
transmission of epigenetic information. The research may provide important
novel insights into the development of diagnosis, treatment and prevention
strategies for male infertility. Importantly, the research will also clarify the
mechanisms of epigenetic inheritance, which could help us to understand and
potentially prevent the transmission of acquired diseases such as metabolic
disorders.
- Molekyylibiologia
- Biolääketieteen tutkimusmenetelmät
- Lisääntymisbiologia
- Enrichment of Pachytene Spermatocytes and Spermatids from Mouse Testes Using Standard Laboratory Equipment (2019)
- Journal of Visualized Experiments
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction (2019)
- Nature Communications
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Transcription Factor USF1 Is Required for Maintenance of Germline Stem Cells in Male Mice (2019)
- Endocrinology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Cilia-related protein SPEF2 regulates osteoblast differentiation (2018)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via Its Interaction with TDRD12 (2018)
- Cell Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Germ granule-mediated RNA regulation in male germ cells (2018)
- Reproduction
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Hydroxysteroid (17β) dehydrogenase 1 expressed by Sertoli cells contributes to steroid synthesis and is required for male fertility (2018)
- FASEB Journal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - FYCO1 and autophagy control the integrity of the haploid male germ cell-specific RNP granules (2017)
- Autophagy
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - SPEF2 functions in microtubule-mediated transport in elongating spermatids to ensure proper male germ cell differentiation (2017)
- Development
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The Genetics of Postmeiotic Male Germ Cell Differentiation from Round Spermatids to Mature Sperm (2017) Genetics of Human Infertility Lehtiniemi T., Kotaja N.
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa) - DICER Regulates the Formation and Maintenance of Cell-Cell Junctions in the Mouse Seminiferous Epithelium. (2015)
- Biology of Reproduction
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - KIF1-binding protein interacts with KIF3A in haploid male germ cells (2015)
- Reproduction
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - microRNA in Human Reproduction (2015) microRNA: Medical Evidence Iris Eisenberg, Noora Kotaja, Debra Goldman-Wohl, Tal Imbar
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa) - piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis (2015)
- Genes and Development
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Retromer vesicles interact with RNA granules in haploid male germ cells (2015)
- Molecular and Cellular Endocrinology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - An atlas of chromatoid body components (2014)
- RNA
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Germ Cell-Specific Targeting of DICER or DGCR8 Reveals a Novel Role for Endo-siRNAs in the Progression of Mammalian Spermatogenesis and Male Fertility (2014)
- PLoS ONE
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Isolation of chromatoid bodies from mouse testis as a rich source of short RNAs (2014) Animal Endo-siRNAs Meikar O, Kotaja N.
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa) - MicroRNAs and spermatogenesis (2014)
- Fertility and Sterility
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Retinoblastoma protein (RB) interacts with E2F3 to control terminal differentiation of Sertoli cells (2014)
- Cell Death and Disease
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )