Noora Kotaja
PhD, Professor of Molecular Medicine
nookot@utu.fi +358 29 450 4639 +358 50 477 3367 Kiinamyllynkatu 10 Turku : C539 |
Male fertility; spermatogenesis; male germ cells; gene regulation; RNA regulation; non-coding RNAs; paternal epigenetic inheritance
RNA regulation in male germ cells
Noora Kotaja is a Professor of Molecular
Medicine at the Institute of Biomedicine, University of Turku, Finland. She
obtained PhD in Biomedicine at the University of Helsinki under supervision of
Profs. Olli Jänne and Jorma Palvimo. The title of her PhD thesis was
"Function of PIAS proteins in steroid receptor-dependent signaling" ,
and it was approved with distinction and awarded with PhD theseis award from
the Finnish Academy of Science.She did her postdoctoral training at the
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg,
France, in the research group of Dr. Paolo Sassone-Corsi on germ cell-specific
regulation of gene expression. In 2006, she returned back in Finland to
establish her own research group at the University of Turku, where she received
first an Academy Research Fellow post from the Academy of Finland, followed by
a tenure track Professor position in 2012. Her scientific achievements have
been recognized by L'Oreal Finland for Women in Science award in 2006, Unto
Uotila award form the Finnish Endrocrine Society in 2008 and Young Researcher
award from the International Netwolrk of Young Researchers in Male Fertiliy in
2011 and Yourn Andrologist award from the International Society of Andrology in
2013.
Noora Kotaja's research focuses on the mechanisms of spermatogenesis and
germline-mediated epigenetic inheritance. In particular, her research group is
interested in the epigenetic and posttranscriptional regulation of gene
expression in meiotic and post-meiotic male germ cells, and the role of large
germ cell-specific ribonucleoprotein granules (germ granules) in the control of
germ cell's transcriptome. The research in the Kotaja group combines experimental animal studies
with human cohort studies to elucidate key epigenetic processes required for
the production of fertile spermatozoa and correct transgenerational
transmission of epigenetic information. The research may provide important
novel insights into the development of diagnosis, treatment and prevention
strategies for male infertility. Importantly, the research will also clarify the
mechanisms of epigenetic inheritance, which could help us to understand and
potentially prevent the transmission of acquired diseases such as metabolic
disorders.
- Molecular biology
- Biomedical research methods
- Reproductive biology
- Exposure to childhood maltreatment is associated with specific epigenetic patterns in sperm (2025)
- Molecular Psychiatry
- Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs (2024)
- Nature
- Germline-specific RNA helicase DDX4 forms cytoplasmic granules in cancer cells and promotes tumor growth (2024)
- Cell Reports
- Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro (2024)
- Andrology
- P050 / Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro (2024)
- Andrology
- Small Non-Coding RNAs in Male Reproduction (2024)
- Seminars in Reproductive Medicine
- Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis (2023)
- Reproduction
- Imatinib decreases DNA synthesis, germ cell survival, and stem cell proliferation and differentiation in rodent testis (2023)
- Toxicology Letters
- Intermitochondrial cement (IMC) harbors piRNA biogenesis machinery and exonuclease domain-containing proteins EXD1 and EXD2 in mouse spermatocytes (2023)
- Andrology
- STAGETOOL, a Novel Automated Approach for Mouse Testis Histological Analysis (2023)
- Endocrinology
- SMG6 localizes to the chromatoid body and shapes the male germ cell transcriptome to drive spermatogenesis (2022)
- Nucleic Acids Research
- Testicular "Inherited Metabolic Memory" of Ancestral High-Fat Diet Is Associated with Sperm sncRNA Content (2022)
- Biomedicines
- Epigeneettinen periytyminen sukusolulinjassa (2021)
- Duodecim
- Single-Cell Proteomics Reveals the Defined Heterogeneity of Resident Macrophages in White Adipose Tissue (2021)
- Frontiers in Immunology
- Widespread formation of double-stranded RNAs in testis (2021)
- Genome Research
- Ympäristön ja elintapojen vaikutus miesten sukusolujen epigenomiin (2021)
- Duodecim
- DICER regulates the expression of major satellite repeat transcripts and meiotic chromosome segregation during spermatogenesis (2020)
- Nucleic Acids Research
- Small non-coding RNAs and epigenetic inheritance (2020) Beyond Our Genes Tiina Lehtiniemi, Margareeta Mäkelä, Noora Kotaja
- The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency (2020)
- FASEB Journal
- Transillumination-Assisted Dissection of Specific Stages of the Mouse Seminiferous Epithelial Cycle for Downstream Immunostaining Analyses (2020)
- Journal of Visualized Experiments