MD/PhD Olli Raitakari - UTU Tutkimustietojärjestelmä

Olli Raitakari
MD/PhD

- professori,
sydäntutkimuskeskus (väestötutkimuskeskus)
- ,
InFLAMES Lippulaiva (lääketieteellinen tiedekunta)

olli.raitakari@utu.fi

+358 29 450 2304

Kiinamyllynkatu 10

Turku

ORCID-tunniste: https://orcid.org/0000-0001-9365-3702

10_representative_publications.pdf

Asiantuntijuusalueet

cardiovascular and metabolic diseases; risk factors; vascular epidemiology; genetic epidemiology; epidemiology; dietary intervention; cohort studies; follow-up studies

Biografia

EDUCATION AND DEGREES

2001   Docent in Clinical Physiology
1997-1999  Postdoc training, Royal Prince Alfred Hospital, Sydney, Australia
1997   Docent in Epidemiology
1996   Specialist in Clinical Physiology
1995   Doctorate, PhD
1989   Licentiate in Medicine, MD

CURRENT POSITIONS

2017- Professor in Cardiovascular Medicine, Director of the Research Centre of Applied and
Preventive Cardiovascular Medicine, University of Turku, Finland

PAST POSITIONS

2012-2016 Academy Professor, University of Turku

2007-2016 Professor in Cardiovascular Medicine (part time), University of Turku

2007-2008 Senior Scientist Grant, Academy of Finland

2004-2016 Chief Physician, Department of Clinical Physiology and Nuclear Medicine, Turku
University Hospital (leave of absence 2012-2016)

2002-2004 Consultant in Clinical Physiology and Nuclear Medicine, Turku University Hospital

2002 (1 mo) Head of Nuclear Medicine Department, Turku University Hospital

2000-2003 (3 mo) Head of Clinical Physiology Department, Turku University Hospital

2000-2005 Senior Fellow Post, Academy of Finland

1998-2000 Postdoctoral Research Post, Academy of Finland

1996-1997 Consultant in Clinical Physiology, Turku University Hospital

1991-1996 Positions as Resident in Clinical Chemistry, Nuclear Medicine, and Clinical
Physiology, Turku University Hospital

1988-1990 Positions as General Practioner and Resident in Internal Medicine or Surgery

Tutkimus

Evidence suggest that many non-communicable disease outcomes have roots in childhood and may even stem of adverse ancestral exposures. Improved knowledge how various ancestral and early-life exposures lead to adult disease outcomes is essential in developing better preventive practices and policies that lead to improved public health. My mission has been to contribute to this knowledge-base by working in epidemiologic cohort studies with follow-up from childhood to adulthood. I am the Principal Investigator of the Cardiovascular Risk in Young Finns Study (YFS), the largest study in Europe with a follow-up of cardiovascular risk factors from childhood to adulthood. I am also the Director of the STRIP Study, which is a leading long-term pediatric dietary intervention study testing the hypothesis that modifying the fat quality diet will have beneficial effects on cardiovascular risk early in life. During the past years, I have organized several field studies in these cohorts, and introduced novel technologies, such as imaging studies, genetic epidemiology methods and metabolomics approaches in these unique population resources. Our research has contributed to the understanding of pre-clinical development of atherosclerosis in children and young adults, including the effects of diet, life-style, metabolic risk factors, psychological traits and psychosocial factors, inflammation, hormones and genetic markers. For example, by applying non-invasive imaging methods in the Young Finns Study, we have demonstrated that exposure to adverse lipids, elevated blood pressure and obesity in childhood is related to atherosclerosis development in adulthood (JAMA 2003). Subsequent work stemmed from this initial observation has led to numerous original publications that have shown in detail how exposure to a large range of aetiogenic factors early in life contribute to the development of cardio-metabolic outcomes in adulthood. For example, by pooling international i3C Consortium data, we have demonstrated that overweight or obese children who became non-obese by adulthood had similar risks of many cardio-metabolic adult outcomes as individuals who were never obese (NEJM 2011). Thus, the results of our studies have clearly demonstrated that individual’s exposure to various stressors in early life is contributing to his/her adult phenotype and disease risk. The results have had significant impact on preventive practices. As a concrete demonstration of the international recognition and impact of my team’s work, many of our studies are widely cited in all updated paediatric guidelines on cardiovascular prevention both in Europe and in US.

Julkaisut

24/51

Maternal and fetal genetic contribution to gestational weight gain (2018)
- International Journal of Obesity
Warrington NM, Richmond R, Fenstra B, Myhre R, Gaillard R, Paternoster L, Wang CA, Beaumont RN, Das S, Murcia M, Barton SJ, Espinosa A, Thiering E, Atalay M, Pitkanen N, Ntalla I, Jonsson AE, Freathy R, Karhunen V, Tiesler CMT, Allard C, Crawford A, Ring SM, Melbye M, Magnus P, Rivadeneira F, Skotte L, Hansen T, Marsh J, Guxens M, Holloway JW, Grallert H, Jaddoe VWV, Lowe WL, Roumeliotaki T, Hattersley AT, Lindi V, Pahkala K, Panoutsopoulou K, Standl M, Flexeder C, Bouchard L, Nohr E, Marina L, Kogevinas M, Niinikoski H, Dedoussis G, Heinrich J, Reynolds RM, Lakka T, Zeggini E, Raitakari OT, Chatzi L, Inskip HM, Bustamante M, Hivert MF, Jarvelin MR, Sorensen TIA, Pennell C, Felix JF, Jacobsson B, Geller F, Evans DM, Lawlor DA
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Meta-analysis of exome array data identifies six novel genetic loci for lung function (2018)
- Wellcome Open Research
Jackson VE, Latourelle JC, Wain LV, Smith AV, Grove ML, Bartz TM, Obeidat M, Province MA, Gao W, Qaiser B, Porteous DJ, Cassano PA, Ahluwalia TS, Grarup N, Li J, Altmaier E, Marten J, Harris SE, Manichaikul A, Pottinger TD, Li-Gao R, Lind-Thomsen A, Mahajan A, Lahousse L, Imboden M, Teumer A, Prins B, Lyytikäinen LP, Eiriksdottir G, Franceschini N, Sitlani CM, Brody JA, Bossé Y, Timens W, Kraja A, Loukola A, Tang W, Liu Y, Bork-Jensen J, Justesen JM, Linneberg A, Lange LA, Rawal R, Karrasch S, Huffman JE, Smith BH, Davies G, Burkart KM, Mychaleckyj JC, Bonten TN, Enroth S, Lind L, Brusselle GG, Kumar A, Stubbe B; Understanding Society Scientific Group, Kähönen M, Wyss AB, Psaty BM, Heckbert SR, Hao K, Rantanen T, Kritchevsky SB, Lohman K, Skaaby T, Pisinger C, Hansen T, Schulz H, Polasek O, Campbell A, Starr JM, Rich SS, Mook-Kanamori DO, Johansson Å, Ingelsson E, Uitterlinden AG, Weiss S, Raitakari OT, Gudnason V, North KE, Gharib SA, Sin DD, Taylor KD, O'Connor GT, Kaprio J, Harris TB, Pederson O, Vestergaard H, Wilson JG, Strauch K, Hayward C, Kerr S, Deary IJ, Barr RG, de Mutsert R, Gyllensten U, Morris AP, Ikram MA, Probst-Hensch N, Gläser S, Zeggini E, Lehtimäki T, Strachan DP, Dupuis J, Morrison AC, Hall IP, Tobin MD, London SJ
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Molecular genetic overlap between migraine and major depressive disorder (2018)
- European Journal of Human Genetics
Yuanhao Yang, Huiying Zhao, Dorret I Boomsma, Lannie Ligthart, Andrea C. Belin, George Davey Smith, Tonu Esko, Tobias M. Freilinger, Thomas Folkmann Hansen, M. Arfan Ikram, Mikko Kallela, Christian Kubisch, Christofidou Paraskevi, David P. Strachan, Maija Wessman; The International Headache Genetics Consortium, Arn M. J. M. van den Maagdenberg, Gisela M. Terwindt, Dale R. Nyholt
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks (2018)
- Nature Genetics
Florence Demenais, Patricia Margaritte-Jeannin, Kathleen C. Barnes, William O. C. Cookson, Janine Altmüller, Wei Ang, R. Graham Barr, Terri H. Beaty, Allan B. Becker, John Beilby, Hans Bisgaard, Unnur Steina Bjornsdottir, Eugene Bleecker, Klaus Bønnelykke, Dorret I. Boomsma, Emmanuelle Bouzigon, Christopher E. Brightling, Myriam Brossard, Guy G. Brusselle, Esteban Burchard, Kristin M. Burkart, Andrew Bush, Moira Chan-Yeung, Kian Fan Chung, Alexessander Couto Alves, John A. Curtin, Adnan Custovic, Denise Daley, Johan C. de Jongste, Blanca E. Del-Rio-Navarro, Kathleen M. Donohue, Liesbeth Duijts, Celeste Eng, Johan G. Eriksson, Martin Farrall, Yuliya Fedorova, Bjarke Feenstra, Manuel A. Ferreira, Australian Asthma Genetics Consortium (AAGC) collaborators, Maxim B. Freidin, Zofia Gajdos, Jim Gauderman, Ulrike Gehring, Frank Geller, Jon Genuneit, Sina A. Gharib, Frank Gilliland, Raquel Granell, Penelope E. Graves, Daniel F. Gudbjartsson, Tari Haahtela, Susan R. Heckbert, Dick Heederik, Joachim Heinrich, Markku Heliövaara, John Henderson, Blanca E. Himes, Hiroshi Hirose, Joel N. Hirschhorn, Albert Hofman, Patrick Holt, Jouke Hottenga, Thomas J. Hudson, Jennie Hui, Medea Imboden, Vladimir Ivanov, Vincent W. V. Jaddoe, Alan James, Christer Janson, Marjo-Riitta Jarvelin, Deborah Jarvis, Graham Jones, Ingileif Jonsdottir, Pekka Jousilahti, Michael Kabesch, Mika Kähönen, David B. Kantor, Alexandra S. Karunas, Elza Khusnutdinova, Gerard H. Koppelman, Anita L. Kozyrskyj, Eskil Kreiner, Michiaki Kubo, Rajesh Kumar, Ashish Kumar, Mikko Kuokkanen, Lies Lahousse, Tarja Laitinen, Catherine Laprise, Mark Lathrop, Susanne Lau, Young-Ae Lee, Terho Lehtimäki, Sébastien Letort, Albert M. Levin, Guo Li, Liming Liang, Laura R. Loehr, Stephanie J. London, Daan W. Loth, Ani Manichaikul, Ingo Marenholz, Fernando J. Martinez, Melanie C. Matheson, Rasika A. Mathias, Kenji Matsumoto, Hamdi Mbarek, Wendy L. McArdle, Mads Melbye, Erik Melén, Deborah Meyers, Sven Michel, Hamida Mohamdi, Arthur W. Musk, Rachel A. Myers, Maartje A. E. Nieuwenhuis, Emiko Noguchi, George T. O’Connor, Ludmila M. Ogorodova, Cameron D. Palmer, Aarno Palotie, Julie E. Park, Craig E. Pennell, Göran Pershagen, Alexey Polonikov, Dirkje S. Postma, Nicole Probst-Hensch, Valery P. Puzyrev, Benjamin A. Raby, Olli T. Raitakari, Adaikalavan Ramasamy, Stephen S. Rich, Colin F. Robertson, Muhammad T. Salam, Veikko Salomaa, Vivi Schlünssen, Robert Scott, Polina A. Selivanova, Torben Sigsgaard, Angela Simpson, Valérie Siroux, Lewis J. Smith, Maria Solodilova, Marie Standl, Kari Stefansson, David P. Strachan, Bruno H. Stricker, Atsushi Takahashi, Philip J. Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Carla M. T. Tiesler, Dara G. Torgerson, Tatsuhiko Tsunoda, Ralf J. P. van der Valk, Amaury Vaysse, Sailaja Vedantam, Andrea von Berg, Erika von Mutius, Judith M. Vonk, Johannes Waage, Nick J. Wareham, Scott T. Weiss, Wendy B. White, Magnus Wickman, Elisabeth Widén, Gonneke Willemsen, L. Keoki Williams, Inge M. Wouters, James J. Yang, Jing Hua Zhao, Miriam F. Moffatt, Carole Ober, Dan L. Nicolae
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects (2018)
- Human Molecular Genetics
Sliz E, Sebert S, Wurtz P, Kangas AJ, Soininen P, Lehtimaki T, Kahonen M, Viikari J, Mannikko M, Ala-Korpela M, Raitakari OT, Kettunen J
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Neighbourhood socioeconomic disadvantage, risk factors, and diabetes from childhood to middle age in the Young Finns Study: a cohort study (2018)
- Lancet Public Health
Kivimäki Mika, Vahtera Jussi, Tabák Adam G, Halonen, Jaana I, Vineis Paolo, Pentti Jaana, Pahkala Katja, Rovio Suvi, Viikari Jorma, Kähönen Mika, Juonala Markus, Ferrie Jane E, Stringhini Silvia, Raitakari Olli T
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries (2018)
- PLoS ONE
Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo XQ, Franceschini N, Cheng CY, Sim XL, Vojinovic D, Marten J, Musani SK, Li CW, Bentley AR, Brown MR, Schwander K, Richard MA, Noordam R, Aschard H, Bartz TM, Bielak LF, Dorajoo R, Fisher V, Hartwig FP, Horimoto ARVR, Lohman KK, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Wojczynski MK, Alver M, Boissel M, Cai QY, Campbell A, Chai JF, Chen X, Divers J, Gao C, Goel A, Hagemeijer Y, Harris SE, He MI, Hsu FC, Jackson AU, Kahonen M, Kasturiratne A, Komulainen P, Kuhnel B, Laguzzi F, Luan J, Matoba N, Nolte IM, Padmanabhan S, Riaz M, Rueedi R, Robino A, Said MA, Scott RA, Sofer T, Stancakova A, Takeuchi F, Tayo BO, van der Most PJ, Varga TV, Vitart V, Wang YJ, Ware EB, Warren HR, Weiss S, Wen WQ, Yanek LR, Zhang WH, Zhao JH, Afaq S, Amin N, Amini M, Arking DE, Aung T, Boerwinkle E, Borecki I, Broeckel U, Brown M, Brumat M, Burke GL, Canouil M, Chakravarti A, Charumathi S, Chen YDI, Connell JM, Correa A, Fuentes LDL, de Mutsert R, de Silva HJ, Deng X, Ding J, Duan Q, Eaton CB, Ehret G, Eppinga RN, Evangelou E, Fau JD, Felix SB, Forouhi NG, Forrester T, Franco OH, Friedlander Y, Gandin I, Gao H, Ghanbari M, Gigante B, Gu CC, Gu DF, Hagenaars SP, Hallmans G, Harris TB, He J, Heikkinen S, Heng CK, Hirata M, Howard BV, Ikram MA, John U, Katsuya T, Khor CC, Kilpelainen TO, Koh WP, Krieger JE, Kritchevsky SB, Kubo M, Kuusisto J, Lakka TA, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lewis CE, Li YZ, Lin S, Liu JJ, Liu JM, Loh M, Louie T, Magi R, McKenzie CA, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mohlke KL, Momozawa Y, Nalls MA, Nelson CP, Sotoodehnia N, Norris JM, O'Connell JR, Palmer ND, Perls T, Pedersen NL, Peters A, Peyser PA, Poulter N, Raffel LJ, Raitakari OT, Roll K, Rose LM, Rosendaal FR, Rotter JI, Schmidt CO, Schreiner PJ, Schupf N, Scott WR, Sever PS, Shi Y, Sidney S, Sims M, Sitlani CM, Smith JA, Snieder H, Starr JM, Strauch K, Stringham HM, Tan NYQ, Tang H, Taylor KD, Teo YY, Tham YC, Turner ST, Uitterlinden AG, Vollenweider P, Waldenberger M, Wang LH, Wang YX, Bin Wei W, Williams C, Yao J, Yu CZ, Yuan JM, Zhao W, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Deary IJ, Esko T, Farrall M, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Jonas JB, Kamatani Y, Kato N, Kooner JS, Kutalik Z, Laakso M, Laurie CC, Leander K, Lehtimaki T, Study LC, Magnusson PKE, Oldehinkel AJ, Penninx BWJH, Poiasek O, Porteous DJ, Rauramaa R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Wu TC, Zheng W, Bouchard C, Christensen K, Evans MK, Gudnason V, Horta BL, Kardia SLR, Liu YM, Pereira AC, Psaty BM, Ridker PM, van Dam RM, Gauderman WJ, Zhu XF, Mook-Kanamori DO, Fornage M, Rotimi CN, Cupples LA, Kelly TN, Fox ER, Hayward C, van Duijn CM, Tai ES, Wong TY, Kooperberg C, Palmas W, Rice K, Morrison AC, Elliott P, Caulfield MJ, Munroe PB, Rao DC, Province MA, Levy D, Levy D, Province MA, Munroe PB, Rao DC
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Oxytocin receptor gene (OXTR) variant rs1042778 moderates the influence of family environment on changes in perceived social support over time (2018)
- Journal of Affective Disorders
Henrik Dobewall, Christian Hakulinen, Liisa Keltikangas-Järvinen, Laura Pulkki-Råback, Ilkka Seppälä, Terho Lehtimäki, Olli T. Raitakari, Mirka Hintsanen
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Pediatric metabolic syndrome: Long-term risks for type 2 diabetes and cardiovascular disease (2018) Pediatric Obesity : Etiology, Pathogenesis and Treatment Magnussen C., Fraser B., Raitakari O.
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa)
Physical Inactivity from Youth to Adulthood and Risk of Impaired Glucose Metabolism (2018)
- Medicine and Science in Sports and Exercise
Petri Kallio, Katja Pahkala, Olli J. Heinonen, Tuija Tammelin, Mirja Hirvensalo, Risto Telama, Markus Juonala, Costan G. Magnussen, Suvi Rovio, Harri Helajärvi, Nina Hutri-Kähönen, Jorma Viikari, Olli T. Raitakari
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity (2018)
- Nature Communications
van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS, Gibson Q, Gudbjartsson DF, Kerr KF, Krijthe BP, Lyytikainen LP, Muller C, Muller-Nurasyid M, Nolte IM, Padmanabhan S, Ritchie MD, Robino A, Smith AV, Steri M, Tanaka T, Teumer A, Trompet S, Ulivi S, Verweij N, Yin XY, Arnar DO, Asselbergs FW, Bader JS, Barnard J, Bis J, Blankenberg S, Boerwinkle E, Bradford Y, Buckley BM, Chung MK, Crawford D, den Hoed M, Denny JC, Dominiczak AF, Ehret GB, Eijgelsheim M, Ellinor PT, Felix SB, Franco OH, Franke L, Harris TB, Holm H, Ilaria G, Iorio A, Kahonen M, Kolcic I, Kors JA, Lakatta EG, Launer LJ, Lin HH, Lin HJ, Loos RJF, Lubitz SA, Macfarlane PW, Magnani JW, Leach IM, Meitinger T, Mitchell BD, Munzel T, Papanicolaou GJ, Peters A, Pfeufer A, Pramstaller PP, Raitakari OT, Rotter JI, Rudan I, Samani NJ, Schlessinger D, Aldana CTS, Sinner MF, Smith JD, Snieder H, Soliman EZ, Spector TD, Stott DJ, Strauch K, Tarasov KV, Thorsteinsdottir U, Uitterlinden AG, Van Wagoner DR, Volker U, Volzke H, Waldenberger M, Westra HJ, Wild PS, Zeller T, Alonso A, Avery CL, Bandinelli S, Benjamin EJ, Cucca F, Dorr M, Ferrucci L, Gasparini P, Gudnason V, Hayward C, Heckbert SR, Hicks AA, Jukema JW, Kaab S, Lehtimaki T, Liu YM, Munroe PB, Parsa A, Polasek O, Psaty BM, Roden DM, Schnabel RB, Sinagra G, Stefansson K, Stricker BH, van der Harst P, van Duijn CM, Wilson JF, Gharib SA, de Bakker PIW, Isaacs A, Arking DE, Sotoodehnia N, Sotoodehnia N, Arking DE, Isaacs A, de Bakker PIW, Gharib SA, Wilson JF
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (2018)
- Nature Genetics
Veronesi G., Vestergaard H., Velez Edwards D., Vermeulen S., Varga T., Varma R., Vanhala M., Varbo A., Wallentin L., Wang F., Wagenknecht L., Walker M., Völker U., Vuckovic D., Vitart V., Vogt T., Wessel J., Waterworth D., Warren H., Wareham N., Ware E., Wang Y., Wang S., Wang C., Yao J., Yaghootkar H., Wu Y., Wood A., Witte D., Wilson J., Willer C., White H., Stringham H., Stumvoll M., Sun L., Surendran P., Stefansson K., Steinthorsdottir V., Stirrups K., Strauch K., Taylor K., Teumer A., Thompson D., Thorleifsson G., Swift A., Tada H., Tansey K., Tardif J., Tsafantakis E., Trompet S., Tybjaerg-Hansen A., Tuomilehto J., Thuesen B., Thorsteinsdottir U., Tromp G., Tönjes A., Duijn C., Laan S., Van Setten J., Leeuwen N., Uher R., Tyrer J., Uusitupa M., Uitterlinden A., Yao P., Yerges-Armstrong L., Young R., Zeggini E., Zhan X., Zhang W., Zhao J., Zhao W., Zhou W., Zondervan K., Rotter J., Pospisilik J., Rivadeneira F., Borecki I., Deloukas P., Frayling T., North K., Lettre G., Hirschhorn J., Lindgren C., Loos R., Giri A., Esko T., Guo X., Graff M., Justice A., Schurmann C., Bradfield J., Fine R., Turcot V., Highland H., Lu Y., Medina-Gomez C., Mudgal P., Ng M., Reiner A., Alfred T., Feitosa M., Masca N., Manning A., Mahajan A., Marouli E., Sivapalaratnam S., Young K., Hendricks A., Karaderi T., Lempradl A., Locke A., Benn M., Bastarache L., Barroso I., Bang L., Balkau B., Auer P., Asselbergs F., Amouyel P., Allison M., Alharthi S., Alam D., Aben K., Abecasis G., Winkler T., Willems S., Vedantam S., Broer L., Brumat M., Breen G., Brilliant M., Bowden D., Brandslund I., Bots M., Bottinger E., Böger C., Bork-Jensen J., Boeing H., Boerwinkle E., Blüher M., Boehnke M., Bergmann S., Bielak L., Crosslin D., Cox A., Corominas Galbany J., Corley J., Davies G., Danesh J., D'Eustacchio A., Cuellar-Partida G., Deary I., Mutsert R., Groot M., Bakker P., Hollander A., Heijer M., Demerath E., Dedoussis G., Campbell P., Cappellani S., Burt A., Butterworth A., Caulfield M., Chambers J., Carey D., Catamo E., Chowdhury R., Christensen C., Chasman D., Chen Y., Collins F., Cook J., Chu A., Cocca M., Fauser S., Faul J., Ferrannini E., Feng S., Florez J., Ferrieres J., Fornage M., Ford I., Franke A., Franco O., Friedrich N., Franks P., Galesloot T., Frikke-Schmidt R., Gandin I., Gan W., Ruijter H., Dennis J., Denny J., Angelantonio E., Drenos F., Du M., Dubé M., Dunning A., Easton D., Edwards T., Ellinghaus D., Ellinor P., Elliott P., Evangelou E., Farmaki A., Farooqi I., Heard-Costa N., He L., Hayward C., Have C., Hattersley A., Harris T., Harris K., Hansen T., Howson J., Hovingh G., Holmen O., Hewitt A., Hernesniemi J., Helgeland Ø., Heid I., Heath A., Grabe H., Grant S., Gordon-Larsen P., Gorski M., Giedraitis V., Gjesing A., Gasparini P., Gibson J., Hakonarson H., Hammerschlag A., Gustafsson S., Haessler J., Grove M., Gudnason V., Grarup N., Griffiths H., Kardia S., Karaleftheri M., Kathiresan S., Karpe F., Kamstrup P., Kähönen M., Kaprio J., Kanoni S., Kooner J., Komulainen P., Korhonen T., Kooperberg C., Kiemeney L., Kee F., Kitajima H., Kim E., Ingelsson E., Jackson A., Jansson J., Jarvik G., Hu Y., Huang P., Huffman J., Ikram M., Jørgensen T., Jukema J., Kahali B., Kahn R., Jensen G., Jia Y., Johansson S., Jørgensen M., Liu D., Liu Y., Linneberg A., Liu C., Lotery A., Loukola A., Lo K., Lophatananon A., Lin H., Lin K., Li J., Li-Gao R., Lind L., Lindström J., Lin L., Lin X., Larson E., Langenberg C., Lange L., Lange E., Li H., Lewis C., Lehtimäki T., Lee N., Kuulasmaa K., Kutalik Z., Kuivaniemi H., Kovacs P., Lamparter D., Lakka T., Laakso M., Kuusisto J., Nalls M., Narisu N., Nelson C., Neville M., Nielsen S., Nikus K., Njølstad P., Nordestgaard B., Montgomery G., Mook-Kanamori D., Moore C., Mori T., Morris A., Morris A., Müller-Nurasyid M., Munroe P., Meidtner K., Medland S., Mistry V., Milani L., Mohlke K., Mitchell P., Moitry M., Moilanen L., Lubitz S., Luan J., Männistö S., Lyytikäinen L., Mazul A., Marenne G., McKean-Cowdin R., McCarthy M., Rasheed A., Rauramaa R., Puolijoki H., Raitakari O., Polasek O., Polderman T., Peyser P., Pirie A., Peters A., Petersen E., Pers T., Person T., Perry J., Perry J., Pennell C., Perola M., Peloso G., Peissig P., Pedersen O., Pattie A., Patel A., Pasterkamp G., Palmer N., Palmer C., Padmanabhan S., Packard C., Owen K., Ophoff R., Olde Loohuis L., O'Donoghue M., O'Connel J., Nyholt D., Southam L., Spector T., Speliotes E., Starr J., Sim X., Slater A., Small K., Smith A., Scott R., Segura-Lepe M., Shah S., Sheu W., Sattar N., Schoen R., Schreiner P., Schulze M., Salomaa V., Saleheen D., Sapkota Y., Samani N., Rolandsson O., Robino A., Ruth K., Rudan I., Rivas M., Rioux J., Robertson N., Roberts D., Renström F., Reilly D., Ridker P., Rheinberger M.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Pulse Wave Velocity Predicts the Progression of Blood Pressure and Development of Hypertension in Young Adults (2018)
- Hypertension
Teemu Koivistoinen, Leo-Pekka Lyytikäinen, Heikki Aatola, Tiina Luukkaala, Markus Juonala, Jorma Viikari, Terho Lehtimäki, Olli T. Raitakari, Mika Kähönen, Nina Hutri-Kähönen
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Seerumin aminohappojen yhteydet insuliiniresistenssin kehittymiseen nuorilla aikuisilla (2018)
- BestPractice Diabetes ja sydänsairaudet
Olli Raitakari
(D1 Artikkeli ammattilehdessä)
Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis (2018)
- Scientific Reports
Santosh D. Bhosale, Robert Moulder, Mikko S. Venäläinen, Juhani S. Koskinen, Niina Pitkänen, Markus T. Juonala, Mika A. P. Kähönen, Terho J. Lehtimäki, Jorma S. A. Viikari, Laura L. Elo, David R. Goodlett, Riitta Lahesmaa, Olli T. Raitakari
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (2018)
- Nature Communications
Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Liewald DCM, Okely JA, Ahola-Olli AV, Barnes CLK, Bertram L, Bis JC, Burdick KE, Christoforou A, DeRosse P, Djurovic S, Espeseth T, Giakoumaki S, Giddaluru S, Gustavson DE, Hayward C, Hofer E, Ikram MA, Karlsson R, Knowles E, Lahti J, Leber M, Li S, Mather KA, Melle I, Morris D, Oldmeadow C, Palviainen T, Payton A, Pazoki R, Petrovic K, Reynolds CA, Sargurupremraj M, Scholz M, Smith JA, Smith AV, Terzikhan N, Thalamuthu A, Trompet S, Lee SJD, Ware EB, Windham BG, Wright MJ, Yang J, Yu J, Ames D, Amin N, Amouyel P, Andreassen OA, Armstrong NJ, Assareh AA, Attia JR, Attix D, Avramopoulos D, Bennett DA, Boehmer AC, Boyle PA, Brodaty H, Campbell H, Cannon TD, Cirulli ET, Congdon E, Conley ED, Corley J, Cox SR, Dale AM, Dehghan A, Dick D, Dickinson D, Eriksson JG, Evangelou E, Faul JD, Ford I, Freimer NA, Gao H, Giegling I, Gillespie NA, Gordon SD, Gottesman RF, Griswold ME, Gudnason V, Harris TB, Hartmann AM, Hatzimanolis A, Heiss G, Holliday EG, Joshi PK, Kahonen M, Kardia SLR, Karlsson I, Kleineidam L, Knopman DS, Kochan NA, Konte B, Kwok JB, Hellard S, Lee T, Lehtimaki T, Li SC, Liu T, Koini M, London E, LongstrethJr WT, Lopez OL, Loukola A, Luck T, Lundervold AJ, Lundquist A, Lyytikainen LP, Martin NG, Montgomery GW, Murray AD, Need AC, Noordam R, Nyberg L, Ollier W, Papenberg G, Pattie A, Polasek O, Poldrack RA, Psaty BM, Reppermund S, Riedel-Heller SG, Rose RJ, Rotter JI, Roussos P, Rovio SP, Saba Y, Sabb FW, Sachdev PS, Satizabal CL, Schmid M, Scott RJ, Scult MA, Simino J, Slagboom PE, Smyrnis N, Soumare A, Stefanis NC, Stott DJ, Straub RE, Sundet K, Taylor AM, Taylor KD, Tzoulaki I, Tzourio C, Uitterlinden A, Vitart V, Voineskos AN, Kaprio J, Wagner M, Wagner H, Weinhold L, Wen KH, Widen E, Yang Q, Zhao W, Adams HHH, Arking DE, Bilder RM, Bitsios P, Boerwinkle E, Chiba-Falek O, Corvin A, Jager PL, Debette S, Donohoe G, Elliott P, Fitzpatrick AL, Gill M, Glahn DC, Hagg S, Hansell NK, Hariri AR, Ikram MK, Jukema JW, Vuoksimaa E, Keller MC, Kremen WS, Launer L, Lindenberger U, Palotie A, Pedersen NL, Pendleton N, Porteous DJ, Raikkonen K, Raitakari OT, Ramirez A, Reinvang I, Rudan I, Rujescu D, Schmidt R, Schmidt H, Schofield PW, Schofield PR, Starr JM, Steen VM, Trollor JN, Turner ST, Duijn CM, Villringer A, Weinberger DR, Weir DR, Wilson JF, Malhotra A, McIntosh AM, Gale CR, Seshadri S, MosleyJr TH, Bressler J, Lencz T, Deary IJ,
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Success in Achieving the Targets of the 20-Year Infancy-Onset Dietary Intervention: Association With Insulin Sensitivity and Serum Lipids (2018)
- Diabetes Care
Laitinen TT, Nuotio J, Juonala M, Niinikoski H, Rovio S, Viikari JSA, Ronnemaa T, Magnussen CG, Jokinen E, Lagstrom H, Jula A, Simell O, Raitakari OT, Pahkala K
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis (2018)
- Diabetologia
McKeown N.M., Dashti H.S., Ma J., Haslam D.E., Kiefte-de Jong J.C., Smith C.E., Tanaka T., Graff M., Lemaitre R.N., Rybin D., Sonestedt E., Frazier-Wood A.C., Mook-Kanamori D.O., Li Y., Wang C.A., Leermakers E.T.M., Mikkilä V., Young K.L., Mukamal K.J., Cupples L.A., Schulz C.-A., Chen T.-A., Li-Gao R., Huang T., Oddy W.H., Raitakari O., Rice K., Meigs J.B., Ericson U., Steffen L.M., Rosendaal F.R., Hofman A., Kähönen M., Psaty B.M., Brunkwall L., Uitterlinden A.G., Viikari J., Siscovick D.S., Seppälä I., North K.E., Mozaffarian D., Dupuis J., Orho-Melander M., Rich S.S., de Mutsert R., Qi L., Pennell C.E., Franco O.H., Lehtimäki T., Herman M.A.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population (2018)
- Ophthalmology: Journal of The American Academy of Ophthalmology
Mauschitz MM, Bonnemaijer PWM, Diers K, Rauscher FG, Elze T, Engel C, Loeffler M, Colijn JM, Ikram MA, Vingerling JR, Williams KM, Hammond CJ, Creuzot-Garcher C, Bron AM, Silva R, Nunes S, Delcourt C, Cougnard-Grégoire A, Holz FG, Klaver CCW, Breteler MMB, Finger RP; on behalf of the European Eye Epidemiology (E3) Consortium
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
The co-occurrence between depressive symptoms and paranoid ideation: A population-based longitudinal study (2018)
- Journal of Affective Disorders
Aino Saarinen, Mirka Hintsanen, Christian Hakulinen, Laura Pulkki-Råback, Terho Lehtimäki, Olli Raitakari, Liisa Keltikangas-Järvinen
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )