A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Cardiovascular Risk Factors in Childhood and Left Ventricular Diastolic Function in Adulthood




Julkaisun tekijät: Heiskanen JS, Ruohonen S, Rovio SP, Pahkala K, Kyto V, Kahonen M, Lehtimaki T, Viikari JSA, Juonala M, Laitinen T, Tossavainen P, Jokinen E, Hutri-Kahonen N, Raitakari OT

Kustantaja: AMER ACAD PEDIATRICS

Julkaisuvuosi: 2021

Journal: Pediatrics

Tietokannassa oleva lehden nimi: PEDIATRICS

Lehden akronyymi: PEDIATRICS

Volyymi: 147

Sivujen määrä: 8

ISSN: 0031-4005

DOI: http://dx.doi.org/10.1542/peds.2020-016691

Verkko-osoite: https://doi.org/10.1542/peds.2020-016691


Tiivistelmä
BACKGROUND AND OBJECTIVES: Cardiovascular risk factors, such as obesity, blood pressure, and physical inactivity, have been identified as modifiable determinants of left ventricular (LV) diastolic function in adulthood. However, the links between childhood cardiovascular risk factor burden and adulthood LV diastolic function are unknown. To address this lack of knowledge, we aimed to identify childhood risk factors associated with LV diastolic function in the participants of the Cardiovascular Risk in Young Finns Study.METHODS: Study participants (N = 1871; 45.9% men; aged 34-49 years) were examined repeatedly between the years 1980 and 2011. We determined the cumulative risk exposure in childhood (age 6-18 years) as the area under the curve for systolic blood pressure, adiposity (defined by using skinfold and waist circumference measurements), physical activity, serum insulin, triglycerides, total cholesterol, and high- and low-density lipoprotein cholesterols. Adulthood LV diastolic function was defined by using E/e ratio.RESULTS: Elevated systolic blood pressure and increased adiposity in childhood were associated with worse adulthood LV diastolic function, whereas higher physical activity level in childhood was associated with better adulthood LV diastolic function (P<.001 for all). The associations of childhood adiposity and physical activity with adulthood LV diastolic function remained significant (both P<.05) but were diluted when the analyses were adjusted for adulthood systolic blood pressure, adiposity, and physical activity. The association between childhood systolic blood pressure and adult LV diastolic function was diluted to nonsignificant (P=.56).CONCLUSIONS: Adiposity status and the level of physical activity in childhood are independently associated with LV diastolic function in adulthood.


Last updated on 2021-24-06 at 08:13