MD/PhD Olli Raitakari - UTU Research Portal

Olli Raitakari
MD/PhD

- Professor,
Cardiovascular Medicine (CAPC) (Centre for Population Health Research (POP Centre))
- ,
InFLAMES Flagship (Faculty of Medicine)

olli.raitakari@utu.fi

+358 29 450 2304

Kiinamyllynkatu 10

Turku

: https://orcid.org/0000-0001-9365-3702

10_representative_publications.pdf

cardiovascular and metabolic diseases; risk factors; vascular epidemiology; genetic epidemiology; epidemiology; dietary intervention; cohort studies; follow-up studies

EDUCATION AND DEGREES

2001   Docent in Clinical Physiology
1997-1999  Postdoc training, Royal Prince Alfred Hospital, Sydney, Australia
1997   Docent in Epidemiology
1996   Specialist in Clinical Physiology
1995   Doctorate, PhD
1989   Licentiate in Medicine, MD

CURRENT POSITIONS

2017- Professor in Cardiovascular Medicine, Director of the Research Centre of Applied and
Preventive Cardiovascular Medicine, University of Turku, Finland

PAST POSITIONS

2012-2016 Academy Professor, University of Turku

2007-2016 Professor in Cardiovascular Medicine (part time), University of Turku

2007-2008 Senior Scientist Grant, Academy of Finland

2004-2016 Chief Physician, Department of Clinical Physiology and Nuclear Medicine, Turku
University Hospital (leave of absence 2012-2016)

2002-2004 Consultant in Clinical Physiology and Nuclear Medicine, Turku University Hospital

2002 (1 mo) Head of Nuclear Medicine Department, Turku University Hospital

2000-2003 (3 mo) Head of Clinical Physiology Department, Turku University Hospital

2000-2005 Senior Fellow Post, Academy of Finland

1998-2000 Postdoctoral Research Post, Academy of Finland

1996-1997 Consultant in Clinical Physiology, Turku University Hospital

1991-1996 Positions as Resident in Clinical Chemistry, Nuclear Medicine, and Clinical
Physiology, Turku University Hospital

1988-1990 Positions as General Practioner and Resident in Internal Medicine or Surgery

Evidence suggest that many non-communicable disease outcomes have roots in childhood and may even stem of adverse ancestral exposures. Improved knowledge how various ancestral and early-life exposures lead to adult disease outcomes is essential in developing better preventive practices and policies that lead to improved public health. My mission has been to contribute to this knowledge-base by working in epidemiologic cohort studies with follow-up from childhood to adulthood. I am the Principal Investigator of the Cardiovascular Risk in Young Finns Study (YFS), the largest study in Europe with a follow-up of cardiovascular risk factors from childhood to adulthood. I am also the Director of the STRIP Study, which is a leading long-term pediatric dietary intervention study testing the hypothesis that modifying the fat quality diet will have beneficial effects on cardiovascular risk early in life. During the past years, I have organized several field studies in these cohorts, and introduced novel technologies, such as imaging studies, genetic epidemiology methods and metabolomics approaches in these unique population resources. Our research has contributed to the understanding of pre-clinical development of atherosclerosis in children and young adults, including the effects of diet, life-style, metabolic risk factors, psychological traits and psychosocial factors, inflammation, hormones and genetic markers. For example, by applying non-invasive imaging methods in the Young Finns Study, we have demonstrated that exposure to adverse lipids, elevated blood pressure and obesity in childhood is related to atherosclerosis development in adulthood (JAMA 2003). Subsequent work stemmed from this initial observation has led to numerous original publications that have shown in detail how exposure to a large range of aetiogenic factors early in life contribute to the development of cardio-metabolic outcomes in adulthood. For example, by pooling international i3C Consortium data, we have demonstrated that overweight or obese children who became non-obese by adulthood had similar risks of many cardio-metabolic adult outcomes as individuals who were never obese (NEJM 2011). Thus, the results of our studies have clearly demonstrated that individual’s exposure to various stressors in early life is contributing to his/her adult phenotype and disease risk. The results have had significant impact on preventive practices. As a concrete demonstration of the international recognition and impact of my team’s work, many of our studies are widely cited in all updated paediatric guidelines on cardiovascular prevention both in Europe and in US.

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Genome-wide association study does not reveal major genetic determinants for anti-cytomegalovirus antibody response (2012)
- Genes and Immunity
Kuparinen T, Seppala I, Jylhava J, Marttila S, Aittoniemi J, Kettunen J, Viikari J, Kahonen M, Raitakari O, Lehtimaki T, Hurme M
Genome-wide association study identifies multiple loci influencing human serum metabolite levels (2012)
- Nature Genetics
Kettunen J, Tukiainen T, Sarin AP, Ortega-Alonso A, Tikkanen E, Lyytikainen LP, Kangas AJ, Soininen P, Wurtz P, Silander K, Dick DM, Rose RJ, Savolainen MJ, Viikari J, Kahonen M, Lehtimaki T, Pietilainen KH, Inouye M, McCarthy MI, Jula A, Eriksson J, Raitakari OT, Salomaa V, Kaprio J, Jarvelin MR, Peltonen L, Perola M, Freimer NB, Ala-Korpela M, Palotie A, Ripatti S
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture (2012)
- Nature Genetics
Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OME, Amin N, Kemp JP, Koller DL, Li G, Liu CT, Minster RL, Moayyeri A, Vandenput L, Willner D, Xiao SM, Yerges-Armstrong LM, Zheng HF, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Thorleifsson G, Wilson SG, Wilson JF, Aalto V, Alen M, Aragaki AK, Aspelund T, Center JR, Dailiana Z, Duggan DJ, Garcia M, Garcia-Giralt N, Giroux S, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Khusainova R, Kim GS, Kooperberg C, Koromila T, Kruk M, Laaksonen M, Lacroix AZ, Lee SH, Leung PC, Lewis JR, Masi L, Mencej-Bedrac S, Nguyen TV, Nogues X, Patel MS, Prezelj J, Rose LM, Scollen S, Siggeirsdottir K, Smith AV, Svensson O, Trompet S, Trummer O, van Schoor NM, Woo J, Zhu K, Balcells S, Brandi ML, Buckley BM, Cheng SL, Christiansen C, Cooper C, Dedoussis G, Ford I, Frost M, Goltzman D, Gonzalez-Macias J, Kahonen M, Karlsson M, Khusnutdinova E, Koh JM, Kollia P, Langdahl BL, Leslie WD, Lips P, Ljunggren O, Lorenc RS, Marc J, Mellstrom D, Obermayer-Pietsch B, Olmos JM, Pettersson-Kymmer U, Reid DM, Riancho JA, Ridker PM, Rousseau F, Slagboom PE, Tang NLS, Urreizti R, Van Hul W, Viikari J, Zarrabeitia MT, Aulchenko YS, Castano-Betancourt M, Grundberg E, Herrera L, Ingvarsson T, Johannsdottir H, Kwan T, Li R, Luben R, Medina-Gomez C, Palsson ST, Reppe S, Rotter JI, Sigurdsson G, van Meurs JBJ, Verlaan D, Williams FMK, Wood AR, Zhou YH, Gautvik KM, Pastinen T, Raychaudhuri S, Cauley JA, Chasman DI, Clark GR, Cummings SR, Danoy P, Dennison EM, Eastell R, Eisman JA, Gudnason V, Hofman A, Jackson RD, Jones G, Jukema JW, Khaw KT, Lehtimaki T, Liu YM, Lorentzon M, McCloskey E, Mitchell BD, Nandakumar K, Nicholson GC, Oostra BA, Peacock M, Pols HAP, Prince RL, Raitakari O, Reid IR, Robbins J, Sambrook PN, Sham PC, Shuldiner AR, Tylavsky FA, van Duijn CM, Wareham NJ, Cupples LA, Econs MJ, Evans DM, Harris TB, Kung AWC, Psaty BM, Reeve J, Spector TD, Streeten EA, Zillikens MC, Thorsteinsdottir U, Ohlsson C, Karasik D, Richards JB, Brown MA, Stefansson K, Uitterlinden AG, Ralston SH, Ioannidis JPA, Kiel DP, Rivadeneira F
Genome-wide meta-analysis of common variant differences between men and women (2012)
- Human Molecular Genetics
Boraska V, Jeroncic A, Colonna V, Southam L, Nyholt DR, Rayner NW, Perry JRB, Toniolo D, Albrecht E, Ang W, Bandinelli S, Barbalic M, Barroso I, Beckmann JS, Biffar R, Boomsma D, Campbell H, Corre T, Erdmann J, Esko T, Fischer K, Franceschini N, Frayling TM, Girotto G, Gonzalez JR, Harris TB, Heath AC, Heid IM, Hoffmann W, Hofman A, Horikoshi M, Zhao JH, Jackson AU, Hottenga JJ, Jula A, Kahonen M, Khaw KT, Kiemeney LA, Klopp N, Kutalik Z, Lagou V, Launer LJ, Lehtimaki T, Lemire M, Lokki ML, Loley C, Luan JA, Mangino M, Leach IM, Medland SE, Mihailov E, Montgomery GW, Navis G, Newnham J, Nieminen MS, Palotie A, Panoutsopoulou K, Peters A, Pirastu N, Polasek O, Rehnstrom K, Ripatti S, Ritchie GRS, Rivadeneira F, Robino A, Samani NJ, Shin SY, Sinisalo J, Smit JH, Soranzo N, Stolk L, Swinkels DW, Tanaka T, Teumer A, Tonjes A, Traglia M, Tuomilehto J, Valsesia A, van Gilst WH, van Meurs JBJ, Smith AV, Viikari J, Vink JM, Waeber G, Warrington NM, Widen E, Willemsen G, Wright AF, Zanke BW, Zgaga L, Boehnke M, d'Adamo AP, de Geus E, Demerath EW, den Heijer M, Eriksson JG, Ferrucci L, Gieger C, Gudnason V, Hayward C, Hengstenberg C, Hudson TJ, Jarvelin MR, Kogevinas M, Loos RJF, Martin NG, Metspalu A, Pennell CE, Penninx BW, Perola M, Raitakari O, Salomaa V, Schreiber S, Schunkert H, Spector TD, Stumvoll M, Uitterlinden AG, Ulivi S, van der Harst P, Vollenweider P, Volzke H, Wareham NJ, Wichmann HE, Wilson JF, Rudan I, Xue YL, Zeggini E
Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution But No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits (2012)
- Circulation: Cardiovascular Genetics
Kristiansson K, Perola M, Tikkanen E, Kettunen J, Surakka I, Havulinna AS, Stancakova A, Barnes C, Widen E, Kajantie E, Eriksson JG, Viikari J, Kahonen M, Lehtimoki T, Raitakari OT, Hartikainen AL, Ruokonen A, Pouta A, Jula A, Kangas AJ, Soininen P, Ala-Korpela M, Mannisto S, Jousilahti P, Bonnycastle LL, Jarvelin MR, Kuusisto J, Collins FS, Laakso M, Hurles ME, Palotie A, Peltonen L, Ripatti S, Salomaa V
Genotype Prediction of Adult Type 2 Diabetes From Adolescence in a Multiracial Population (2012)
- Pediatrics
Vassy JL, DasMahapatra P, Meigs JB, Schork NJ, Magnussen CG, Chen W, Raitakari OT, Pencina MJ, Jamal SM, Berenson GS, Goodman E
High-throughput quantification of circulating metabolites improves prediction of subclinical atherosclerosis (2012)
- European Heart Journal
Wurtz P, Raiko JR, Magnussen CG, Soininen P, Kangas AJ, Tynkkynen T, Thomson R, Laatikainen R, Savolainen MJ, Laurikka J, Kuukasjarvi P, Tarkka M, Karhunen PJ, Jula A, Viikari JS, Kahonen M, Lehtimaki T, Juonala M, Ala-Korpela M, Raitakari OT
Ideal Cardiovascular Health in Childhood and Cardiometabolic Outcomes in Adulthood The Cardiovascular Risk in Young Finns Study (2012)
- Circulation
Laitinen TT, Pahkala K, Magnussen CG, Viikari JSA, Oikonen M, Taittonen L, Mikkila V, Jokinen E, Hutri-Kahonen N, Laitinen T, Kahonen M, Lehtimaki T, Raitakari OT, Juonala M
Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers (2012)
- Archives of General Psychiatry
Hartz SM, Short SE, Saccone NL, Culverhouse R, Chen LS, Schwantes-An TH, Coon H, Han YH, Stephens SH, Sun JZ, Chen XN, Ducci F, Dueker N, Franceschini N, Frank J, Geller F, Guobjartsson D, Hansel NN, Jiang CH, Keskitalo-Vuokko K, Liu Z, Lyytikainen LP, Michel M, Rawal R, Hum S, Rosenberger A, Scheet P, Shaffer JR, Teumer A, Thompson JR, Vink JM, Vogelzangs N, Wenzlaff AS, Wheeler W, Xiao XJ, Yang BZ, Aggen SH, Balmforth AJ, Baumeister SE, Beaty T, Bennett S, Bergen AW, Boyd HA, Broms U, Campbell H, Chatterjee N, Chen JC, Cheng YC, Cichon S, Couper D, Cucca F, Dick DM, Foroud T, Furberg H, Giegling I, Gu FY, Hall AS, Hallfors J, Han SZ, Hartmann AM, Hayward C, Heikkila K, Hewitt JK, Hottenga JJ, Jensen MK, Jousilahti P, Kaakinen M, Kittner SJ, Konte B, Korhonen T, Landi MT, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Muley T, Murray T, Nauck M, North K, Pergadia M, Polasek O, Ramos EM, Ripatti S, Risch A, Ruczinski I, Rudan I, Salomaa V, Schlessinger D, Styrkarsdottir U, Terracciano A, Uda M, Willemsen G, Wu XF, Abecasis G, Barnes K, Bickeboller H, Boerwinkle E, Boomsma DI, Caporaso N, Duan JB, Edenberg HJ, Francks C, Gejman PV, Gelernter J, Grabe HJ, Hops H, Jarvelin MR, Viikari J, Kahonen M, Kendler KS, Lehtimaki T, Levinson DF, Marazita ML, Marchini J, Melbye M, Mitchell BD, Murray JC, Nothen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Sanders AR, Schwartz AG, Shete S, Shi JX, Spitz M, Stefansson K, Swan GE, Thorgeirsson T, Volzke H, Wei QY, Wichmann HE, Amos CI, Breslau N, Cannon DS, Ehringer M, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Stitzel JA, Weiss RB, Kraft P, Bierut LJ
Indoleamine 2,3-Dioxygenase Activation and Depressive Symptoms: Results From the Young Finns Study (2012)
- Psychosomatic Medicine
Elovainio M, Hurme M, Jokela M, Pulkki-Raback L, Kivimaki M, Hintsanen M, Hintsa T, Lehtimaki T, Viikari J, Raitakari OT, Keltikangas-Jarvinen L
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function (2012)
- Human Molecular Genetics
Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Boger CA, Endlich K, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao XY, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa MF, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tonjes A, Dehghan A, Lambert JC, Holliday EG, Sorice R, Kutalik Z, Lehtimaki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Coassin S, Pistis G, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu F, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding JZ, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T, Meisinger C, Gieger C, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nothlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Volker U, Volzke H, Kovacs P, Stumvoll M, Magi R, Hofman A, Uitterlinden AG, Rivadeneira F, Aulchenko YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Stengel B, Ruggiero D, Bergmann S, Kahonen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Kramer BK, Portas L, Ford I, Buckley BM, Adam M, Thun GA, Paulweber B, Haun M, Sala C, Mitchell P, Ciullo M, Kim SK, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema JW, Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Siscovick DS, van Duijn CM, Borecki IB, Kardia SLR, Liu YM, Curhan GC, Rudan I, Gyllensten U, Wilson JF, Franke A, Pramstaller PP, Rettig R, Prokopenko I, Witteman J, Hayward C, Ridker PM, Parsa A, Bochud M, Heid IM, Kao WHL, Fox CS, Kottgen A
Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure (2012)
- PLoS Genetics
Gaal EI, Salo P, Kristiansson K, Rehnstrom K, Kettunen J, Sarin AP, Niemela M, Jula A, Raitakari OT, Lehtimaki T, Eriksson JG, Widen E, Gunel M, Kurki M, Fraunberg MVZ, Jaaskelainen JE, Hernesniemi J, Jarvelin MR, Pouta A, Newton-Cheh C, Salomaa V, Palotie A, Perola M
Is Sedentary Behavior Associated With Metabolic Syndrome In Adults? The Cardiovascular Risk In Young Finns Study (2012)
- Medicine and Science in Sports and Exercise
Helajarvi H, Pahkala K, Heinonen OJ, Ilkka H, Tammelin T, Hirvensalo M, Mansikkaniemi K, Viikari J, Raitakari O
Lapsuuden elintavat vaikuttavat valtimotaudin kehittymiseen (2012)
- Lääkärilehti
Juonala Markus, Viikari Jorma, Simell Olli, Niinikoski Harri, Raitakari Olli T
Leadership Component of Type A Behavior Predicts Physical Activity in Early Midlife (2012)
- International Journal of Behavioral Medicine
Yang XL, Telama R, Hirvensalo M, Hintsa T, Pulkki-Raback L, Hintsanen M, Keltikangas-Jarvinen L, Viikari JSA, Raitakari OT
Left Ventricular Mass and Geometry in Adolescence Early Childhood Determinants (2012)
- Hypertension
Hietalampi H, Pahkala K, Jokinen E, Ronnemaa T, Viikari JSA, Niinikoski H, Heinonen OJ, Salo P, Simell O, Raitakari OT
Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding (2012)
- Evolution
Verweij KJH, Yang J, Lahti J, Veijola J, Hintsanen M, Pulkki-Raback L, Heinonen K, Pouta A, Pesonen AK, Widen E, Taanila A, Isohanni M, Miettunen J, Palotie A, Penke L, Service SK, Heath AC, Montgomery GW, Raitakari O, Kahonen M, Viikari J, Raikkonen K, Eriksson JG, Keltikangas-Jarvinen L, Lehtimaki T, Martin NG, Jarvelin MR, Visscher PM, Keller MC, Zietsch BP
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (2012)
- Nature Genetics
Okada, Sim, Go, Wu, Gu, Takeuchi, Takahashi, Maeda, Tsunoda, Chen, Lim, Wong, Liu, Young, Aung, Seielstad, Teo, Kim, Lee, Han, Kang, Chen, Tsai, Chang, Fann, Mei, Rao, Hixson, Chen, Katsuya, Isono, Ogihara, Chambers, Zhang, Kooner, KidneyGen Consortium, CKDGen Consortium, Albrecht, GUGC consortium, Yamamoto, Kubo, Nakamura, Kamatani, Kato, He, Chen, Cho, Tai, Tanaka
Metabolic Signatures of Insulin Resistance in 7,098 Young Adults (2012)
- Diabetes
Wurtz P, Makinen VP, Soininen P, Kangas AJ, Tukiainen T, Kettunen J, Savolainen MJ, Tammelin T, Viikari JS, Ronnemaa T, Kahonen M, Lehtimaki T, Ripatti S, Raitakari OT, Jarvelin MR, Ala-Korpela M
Moderating Effects of Leisure-Time Physical Activity on the Association Between Job Strain and Depressive Symptoms The Cardiovascular Risk in Young Finns Study (2012)
- Journal of Occupational and Environmental Medicine
Yang XL, Telama R, Hirvensalo M, Hintsanen M, Hintsa T, Pulkki-Raback L, Keltikangas-Jarvinen L, Viikari JSA, Raitakari OT