MD, PhD, Professor of Biomedicine Sari Mäkelä - UTU Research Portal

Sari Mäkelä
MD, PhD, Professor of Biomedicine

- Professor,
Institute of Biomedicine (Faculty of Medicine)

sarmak@utu.fi

+358 29 450 2536

+358 40 514 3714

Kiinamyllynkatu 10

Turku

: https://orcid.org/0000-0002-8698-4076

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Glucocorticoid receptor-induced non-muscle caldesmon regulates metastasis in castration-resistant prostate cancer (2023)
- Oncogenesis
Virtanen Verneri, Paunu Kreetta, Kukkula Antti, Niva Saana, Junila Ylva, Toriseva Mervi, Jokilehto Terhi, Mäkelä Sari, Huhtaniemi Riikka, Poutanen Matti, Paatero Ilkka, Sundvall Maria
High intratumoral dihydrotestosterone is associated with antiandrogen resistance in VCaP prostate cancer xenografts in castrated mice (2022)
- iScience
Huhtaniemi Riikka, Sipilä Petra, Junnila Arttu, Oksala Riikka, Knuuttila Matias, Mehmood Arfa, Aho Eija, Laajala Teemu D., Aittokallio Tero, Laiho Asta, Elo Laura, Ohlsson Claes, Thulin Malin H., Kallio Pekka, Mäkelä Sari, Mustonen Mika V.J., Poutanen Matti
CC chemokine ligand 2 (CCL2) stimulates aromatase gene expression in mammary adipose tissue (2021)
- FASEB Journal
Martínez-Chacón Gabriela, Yatkin Emrah, Polari Lauri, Dinç Deniz D, Peuhu Emilia, Hartiala Pauliina, Saarinen Niina, Mäkelä Sari
Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts (2018)
- American Journal of Pathology
Huhtaniemi R, Oksala R, Knuuttila M, Mehmood A, Aho E, Laajala TD, Nicorici D, Aittokallio T, Laiho A, Elo L, Ohlsson C, Kallio P, Mäkelä S, Mustonen MVJ, Sipilä P, Poutanen M
Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts (2018)
- American Journal of Pathology
Knuuttila M, Mehmood A, Huhtaniemi R, Yatkin E, Häkkinen MR, Oksala R, Laajala TD, Ryberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M
IL-10 suppresses TNF-α-induced expression of human aromatase gene in mammary adipose tissue (2018)
- FASEB Journal
Gabriela Martínez-Chacón, Kristy A. Brown, Maria M. Docanto, Himanshu Kumar, Seppo Salminen, Niina Saarinen, Sari Mäkelä
Intratumoral androgen levels are linked to TMPRSS2-ERG fusion in prostate cancer (2018)
- Endocrine-Related Cancer
Knuuttila M, Mehmood A, Maki-Jouppila J, Ryberg H, Taimen P, Knaapila J, Ettala O, Bostrom PJ, Ohlsson C, Venalainen MS, Laiho A, Elo LL, Sipila P, Makela SI, Poutanen M
From pure compounds to complex exposure: Effects of dietary cadmium and lignans on estrogen, epidermal growth factor receptor, and mitogen activated protein kinase signaling in vivo (2016)
- Toxicology Letters
Ali I, Hurmerinta T, Nurmi T, Berglund M, Ruegg J, Poutanen M, Halldin K, Makela S, Damdimopoulou P
Optimized design and analysis of preclinical intervention studies in vivo (2016)
- Scientific Reports
Laajala TD, Jumppanen M, Huhtaniemi R, Fey V, Kaur A, Knuuttila M, Aho E, Oksala R, Westermarck J, Mäkelä S, Poutanen M*, Aittokallio T*
Transcriptional response networks for elucidating mechanisms of action of multitargeted agents (2016)
- Drug Discovery Today
Kibble M, Khan SA, Saarinen N, Iorio F, Saez-Rodriguez J, Mäkelä S, Aittokallio T
Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products (2015)
- Natural Product Reports
Kibble M, Saarinen N, Tang J, Wennerberg K, Mäkelä S, Aittokallio T
Weight gain and inflammation regulate aromatase expression in male adipose tissue, as evidenced by reporter gene activity (2015)
- Molecular and Cellular Endocrinology
Polari L., Yatkin E., Martínez Chacón M., Ahotupa M., Smeds A., Strauss L., Zhang F., Poutanen M., Saarinen N., Mäkelä S.
Castration induces up-regulation of intratumoral androgen biosynthesis and androgen receptor expression in an orthotopic VCaP human prostate cancer xenograft model (2014)
- American Journal of Pathology
Matias Knuuttila, Emrah Yatkin, Jenny Kallio, Saija Savolainen, Teemu D. Laajala, Tero Aittokallio, Riikka Oksala, Merja Häkkinen, Pekka Keski-Rahkonen, Seppo Auriola, Matti Poutanen, Sari Mäkelä
Castration induces upregulation of intratumoral androgen biosynthesis and androgen receptor expression in orthotopic VCaP human prostate cancer xenograft model (2014)
- Cancer Research
Matias Knuuttila, Emrah Yatkin, Jenny Kallio, Saija Savolainen, Teemu Daniel Laajala, Tero Aittokallio, Riikka Oksala, Merja Häkkinen, Pekka Keski-Rahkonen, Seppo Auriola, Matti Poutanen, Sari Mäkelä
Deficiency of ERβ and prostate tumorigenesis in FGF8b transgenic mice (2014)
- Endocrine-Related Cancer
Teresa Elo, Lan Yu, Eeva Valve, Sari Mäkelä, Pirkko Härkönen
Lihavuuden vaikutus estrogeenisignalointiin ja rintasyöpäriskiin (2014)
- Lääkärilehti
Saarinen Niina, Mäkelä Sari
Novel Lignan and Stilbenoid Mixture Shows Anticarcinogenic Efficacy in Preclinical PC-3M-luc2 Prostate Cancer Model (2014)
- PLoS ONE
Yatkin E, Polari L, Laajala TD, Smeds A, Eckerman C, Holmbom B, Saarinen N, Aittokallio T, Mäkelä S.
A reporter mouse model reveals that human CYP19A1 (aromatase) gene expression is induced in breast cancer xenograft stroma and surrounding mammary gland by the cancer cells in vivo. (2013)
- Cancer Research
Järvensivu P, Strauss L, Mäkelä S, Poutanen M, Saarinen N
Seminal vesicles and urinary bladder as sites of aromatization of androgens in men, evidenced by a CYP19A1-driven luciferase reporter mouse and human tissue specimens (2013)
- FASEB Journal
Strauss L, Rantakari P, Sjogren K, Salminen A, Lauren E, Kallio J, Damdimopoulou P, Bostrom M, Bostrom PJ, Pakarinen P, Zhang FP, Kujala P, Ohlsson C, Makela S, Poutanen M
Cadmium-Induced Effects on Cellular Signaling Pathways in the Liver of Transgenic Estrogen Reporter Mice (2012)
- Toxicological Sciences
Ali I, Damdimopoulou P, Stenius U, Adamsson A, Makela SI, Akesson A, Berglund M, Hakansson H, Halldin K