Pasi Virta
Professor
pamavi@utu.fi +358 29 450 3209 +358 50 328 5719 |
Synthesis of oligonucleotide, peptide nucleic acid, peptide (including antibodies) and carbohydrate conjugates, Drug delivery strategies of oligonucleotides, mechanistic studies of higher order secondary structures of nucleic acids, 19F NMR spectroscopy, DNA-templated synthesis, aqueous glycosylation
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- Synthesis of an Alkyne-Modified Bleomycin Disaccharide Precursor, Conversion to a F-18-Labeled Radiotracer, and Preliminary in vivo-PET Imaging Studies (2019)
- European Journal of Organic Chemistry
- Synthesis of Glycosidic (beta-1 ''-> 6,3 ' and 4 ') Site Isomers of Neomycin B and Their Effect on RNA and DNA Triplex Stability (2019)
- Molecules
- DNA-Templated N(Me)-Alkoxyamine Glycosylation (2018)
- Organic Letters
- Synthesis and Applicability of Base-Discriminating DNA-Triplex-Forming 19F NMR Probes (2018)
- European Journal of Organic Chemistry
- Synthesis of Azide-Modified Chondroitin Sulfate Precursors: Substrates for "Click"-Conjugation with Fluorescent Labels and Oligonucleotides (2018)
- Bioconjugate Chemistry
- Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics (2017)
- ACS Chemical Biology
- DNA barcoding reveals widespread occurrence of Leptidea juvernica (Lepidoptera: Pieridae) in southern Finland (2017)
- Entomologisk tidskrift
- F-19 NMR Spectroscopic Analysis of the Binding Modes in Triple-Helical Peptide Nucleic Acid (PNA)/MicroRNA Complexes (2017)
- Chemistry - A European Journal
- Synthesis of Aminoglycoside-2 '-O-Methyl Oligoribonucleotide Fusions (2017)
- Molecules
- Zinc Ion-Dependent Peptide Nucleic Acid-Based Artificial Enzyme that Cleaves RNABulge Size and Sequence Dependence (2017)
- Molecules
- Characterization of G-quadruplex/hairpin transitions of RNA by 19F NMR spectroscopy (2016)
- Chemistry - A European Journal
- In-Vivo Bone-Targeting of Bis(phosphonate)-Conjugated Double Helical RNA Monitored by Positron Emission Tomography (2016)
- Molecular Pharmaceutics
- Solid-supported porphyrins useful for the synthesis of conjugates with oligomeric biomolecules (2016)
- Bioconjugate Chemistry
- Synthesis and In Vivo PET Imaging of Hyaluronan Conjugates of Oligonucleotides (2016)
- Bioconjugate Chemistry
- Synthesis of protected 2´-O-deoxyribonucleotides on a precipitative soluble support: a useful procedure for the preparation of trimer phosphoramidites (2016)
- RSC Advances
- 2 '-O-[(4-CF3-triazol-1-yl)methyl] Uridine - A Sensitive F-19 NMR Sensor for the Detection of RNA Secondary Structures (2015)
- Journal of Organic Chemistry
- Assembly of short oligoribonucleotides from commercially available building blocks on a tetrapodal soluble support (2015)
- Current Organic Synthesis
- Preparation of a disulfide-linked precipitative soluble support for solution-phase synthesis of trimeric oligodeoxyribonucleotide 3´-(2-chlorophenylphosphate) building blocks (2015)
- Beilstein Journal of Organic Chemistry
- Synthesis of C-5, C-2 ' and C-4 '-neomycin-conjugated triplex forming oligonucleotides and their affinity to DNA-duplexes (2015)
- Bioorganic and Medicinal Chemistry
- 4 '-C-[(4-Trifluoromethyl-1H-1,2,3-triazol-1-yl)methyl]thymidine as a Sensitive F-19 NMR Sensor for the Detection of Oligonucleotide Secondary Structures (2014)
- Journal of Organic Chemistry
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