Jari Nuutila
PhD
jarnuu@utu.fi +358 29 450 4784 Tykistökatu 6 Turku |
Flow Cytometry; Differential diagnostics; Bacterial Infection; Inflammation; Infectious Disease; Epidemiology; Immunology of Infectious Diseases; Innate Immunity; Viral Infection; Cellular Immunology
PhD
Jari Nuutila, University Teacher and
independent infection researcher (Current, Department of Biochemistry,
University of Turku).
Research
topics: Host-Microbe Interactions. Applications of leukocyte
cell surface receptor expression and serum soluble markers in distinguishing
between febrile bacterial and viral infections.
http://www.utu.fi/fi/yksikot/sci/yksikot/biokemia/tutkimus/bk/immunochemistry/Sivut/home.aspx
Academic
career: MSc
in Biochemistry (Calcium dependence of phagocytosis and respiratory burst
activity measured by flow cytometer and luminometer, 1994), PhD in Biochemistry (Interrelations
between receptor expression, respiratory burst, and phagocytosis, 2004), Adjunct professor/Docent in
Biochemistry (2009, University of Turku) and Immunology (2013, University of
Helsinki)
Publications: 30 scientific publications (27 original and 3 review articles)
The primary goal of this multidisciplinary
basic
research on innate immunology is to study the expression patterns of several leukocyte
cell surface markers and serum soluble markers in infectious/inflammatory
diseases and in healthy controls in order to understand how the mechanisms of
cellular and humoral innate immunity are regulated.
The novelty of this study compared with the
previous studies is that: (A) For the first time ever, such a large panel of
potential bacterial infection markers will be quantified simultaneously, and
(B) The quantitative analysis of these markers will be determined in authentic in vivo circumstances (in patients with
bacterial or viral infections, and in healthy controls).
The second
goal of this study is to transform above-mentioned
basic research findings into clinical diagnostic applications. The
ultimate goal is to find out whether it is possible to produce a novel fast method(s) for
distinguishing between bacterial and viral infections in less than 30
minutes.
Immunology - Theory (42 hours of lectures), Bachelor of Science studies, 4 ECTS
Immunology - Practice (immunological laboratory methods), Bachelor of Science studies, 2 ECTS
Methods in Immunology, Master of Science studies, 2 ECTS
Immonology, Laboratory Exercises, Master of Science studies, 2 ECTS
- Indoor microbial exposure increases complement component C3a and C-reactive protein concentrations in serum (2024)
- Heliyon
- The role of gamma globulin, complement component 1q, factor B, properdin, body temperature, C-reactive protein and serum amyloid alpha to the activity and the function of the human complement system and its pathways (2024)
- Journal of Immunological Methods
- Indoor-related microbe damage induces complement system activation in building users (2021)
- Innate Immunity
- Mikrobivaurioitunut rakennus nostaa tilankäyttäjien seerumin komplementtisysteemin aktiivisuutta (2021) Sisäilmastoseminaari 2021 Atosuo Janne, Karhuvaara Outi, Suominen Eetu, Vilén Liisa, Nuutila Jari, Putus Tuula
- Rapid detection of bacterial infection using a novel single-tube, four-colour flow cytometric method: Comparison with PCT and CRP (2021)
- EBioMedicine
- Indoor exposure to Streptomyces albus and Aspergillus versicolor elevates the levels of spore-specific IgG, IgG1 and IgG3 serum antibodies in building users - A new ELISA-based assay for exposure assessment (2020)
- Science of the Total Environment
- Löytyykö uusia työkaluja sisäilmaongelmaisten työtilojen ja niiden käyttäjien tutkimukseen? Loppuraportti (hanke 180090) (2020) Janne Atosuo, Outi Karhuvaara, Marja Päivinen, Liisa Vilén, Eetu Suominen, Jari Nuutila,Tuula Putus,
- Uusi ELISA-menetelmä kosteusvauriomikrobeille altistumisen havaitsemiseen (2020) Sisäilmastoseminaari 2020 Karhuvaara Outi, Atosuo Janne, Suominen Eetu, Vilén Liisa, Nuutila Jari, Putus Tuula
- A single-tube two-color flow cytometric method for distinguishing between febrile bacterial and viral infections (2018)
- Journal of Microbiological Methods
- Bacterial infection (BI)-INDEX: an improved and simplified rapid flow cytometric bacterial infection marker (2014)
- Diagnostic Microbiology and Infectious Disease
- A rapid flow cytometric method for distinguishing between febrile bacterial and viral infections (2013)
- Journal of Microbiological Methods
- Identification of a Novel Bacterial Outer Membrane Interleukin-1B-Binding Protein from Aggregatibacter actinomycetemcomitans (2013)
- PLoS ONE
- Resistance to bacterial infectious diseases in rainbow trout (Oncorhynchus mykiss) (2013)
- Veterinary Immunology and Immunopathology
- Use of complement regulators, CD35, CD46, CD55, and CD59, on leukocytes as markers for diagnosis of viral and bacterial infections (2013)
- Human Immunology
- Bacterial Infections, DNA Virus Infections, and RNA Virus Infections Manifest Differently in Neutrophil Receptor Expression (2012)
- ScientificWorld Journal
- Phagocytic Cell Surface Markers in Medical Microbiological Research and Diagnosis (2012) The Role of New Technologies in Medical Microbiological Research and Diagnosis Nuutila J
- Trimeric Form of Intracellular ATP Synthase Subunit β of Aggregatibacter actinomycetemcomitans Binds Human Interleukin-1 β (2011)
- PLoS ONE
- The novel applications of the quantitative analysis of neutrophil cell surface Fc gamma RI (CD64) to the diagnosis of infectious and inflammatory diseases (2010)
- Current Opinion in Infectious Diseases
- Simultaneous quantitative analysis of Fc gamma RI (CD64) and CR1 (CD35) on neutrophils in distinguishing between bacterial infections, viral infections, and inflammatory diseases (2009)
- Clinical Immunology
- Simultaneous quantitative analysis of Fc gamma RI (CD64) expression on neutrophils and monocytes: A new, improved way to detect infections (2007)
- Journal of Immunological Methods