Harri Härmä - UTU Research Portal

Harri Härmä

- University Lecturer,
Pharmaseutical Chemistry (Department of Chemistry)

harri.harma@utu.fi

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ADP-ribosyltransferase-based biocatalysis of non-hydrolyzable NAD+ analogs (2025)
- Journal of Biological Chemistry
Sakari, Moona; Bhadane, Rajendra; Kumar, Sujit; Azevedo, Rita; Malakoutikhah, Morteza; Masoumi, Ahmadreza; Littler, Dene R; Härmä, Harri; Kopra, Kari; Pulliainen, Art To
Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96 (2024)
- ACS Chemical Biology
Mahran, Randa; Kapp, Jonas N.; Valtonen, Salla; Champagne, Allison; Ning, Jinying; Gillette, William; Stephen, Andrew G.; Hao, Feng; Pluckthun, Andreas; Härmä, Harri; Pantsar, Tatu; Kopra, Kari
Identification of an H-Ras nanocluster disrupting peptide (2024)
- Communications Biology
Steffen, Candy Laura; Manoharan, Ganesh Babu; Pavic, Karolina; Yeste-Vázquez, Alejandro; Knuuttila, Matias; Arora, Neha; Zhou, Young; Härmä, Harri; Gaigneaux, Anthoula; Grossmann, Tom N.; Abankwa, Daniel Kwaku
Label-free electronic detection of peptide post-translational modification with functional enzyme-driven assay at the physical limit (2024)
- Cell Reports Physical Science
Macchia, Eleonora; Björkström, Kim; Tewari, Amit; Eskonen, Ville; Luukkonen, Axel; Ghafari, Amir Mohammad; Sarcina, Lucia; Caputo, Mariapia; Tong-Ochoa, Natalia; Kopra, Kari; Pettersson, Fredrik; Gounani, Zahra; Torsi, Luisa; Härmä, Harri; Österbacka, Ronald
Homogeneous luminescent quantitation of cellular guanosine and adenosine triphosphates (GTP and ATP) using QT-Luc GTP&ATP assay (2023)
- Analytical and Bioanalytical Chemistry
Kopra Kari, Mahran Randa, Yli-Hollo Titta, Tabata Sho, Vuorinen Emmiliisa, Fujii Yuki, Vuorinen Iida, Ogawa-Iio Aki, Hirayama Akiyoshi, Soga Tomoyoshi, Sasaki Atsuo T, Härmä Harri
Isothermal chemical denaturation assay for monitoring protein stability and inhibitor interactions (2023)
- Scientific Reports
Mahran Randa, Vello Niklas, Komulainen Anita, Malakoutikhah Morteza, Härmä Harri, Kopra Kari
Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes (2023)
- Analytical Chemistry
Malakoutikhah Morteza, Mahran Randa, Gooran Negin, Masoumi Ahmadreza, Lundell Katri, Liljeblad Arto, Guiley Keelan, Dai Shizhong, Zheng Qinheng, Zhu Lawrence, Shokat Kevan M., Kopra Kari, Härmä Harri
Systematic Study of Heteroarene Stacking Using a Congeneric Set of Molecular Glues for Procaspase-6 (2023)
- Journal of Medicinal Chemistry
Togo Takaya, Tram Linh, Denton Laura G., ElHilali-Pollard Xochina, Gu Jun, Jiang Jinglei, Liu Chenglei, Zhao Yan, Zhao Yanlong, Zheng Yinzhe, Zheng Yunping, Yang Jingjing, Fan Panpan, Arkin Michelle R., Härmä Harri, Sun Deqian, Canan Stacie S., Wheeler Steven E., Renslo Adam R.
Luminophore Chemistry for Detection of Urinary Bladder Cancer - Comparison to Cytology and Urinary Rapid Tests (BTA stat®, NMP22® BladderChek® and UBC® Rapid Test) (2022)
- Anticancer Research
Ecke Thorsten H, Scislowski Mikolaj, Hassan Nazia, Saura Mari, Hallmann Steffen, Koch Stefan, Vuolle Sari, Malakoutikhah Morteza, Kopra Kari, Härmä Harri
Rapid high-throughput compatible label-free virus particle quantification method based on time-resolved luminescence (2022)
- Analytical and Bioanalytical Chemistry
Kopra Kari, Hassan Nazia, Vuorinen Emmiliisa, Valtonen Salla, Mahran Randa, Habib Huda, Jalkanen Pinja, Susi Petri, Hytönen Vesa, Hankaniemi Minna, Ylä-Herttuala Seppo, Kakkola Laura, Peurla Markus, Härmä Harri
Thermal Shift Assay for Small GTPase Stability Screening: Evaluation and Suitability (2022)
- International Journal of Molecular Sciences
Kopra Kari, Valtonen Salla, Mahran Randa, Kapp Jonas N, Hassan Nazia, Gillette William, Dennis Bryce, Li Lianbo, Westover Kenneth D, Plückthun Andreas, Härmä Harri
Methods to Monitor Ras Activation State (2021) Ras Activity and Signaling: Methods and Protocols Kopra Kari, Härmä Harri
Protease substrate‐independent universal assay for monitoring digestion of native unmodified proteins (2021)
- International Journal of Molecular Sciences
Vuorinen Emmiliisa, Valtonen Salla, Hassan Nazia, Mahran Randa, Habib Huda, Malakoutikhah Morteza, Kopra Kari, Härmä, Harri
Sensitive, homogeneous, and label-free protein-probe assay for antibody aggregation and thermal stability studies (2021)
- mAbs
Valtonen Salla, Vuorinen Emmiliisa, Eskonen Ville, Malakoutikhah Morteza, Kopra Kari, Härmä Harri
Homogeneous Dual-Parametric-Coupled Assay for Simultaneous Nucleotide Exchange and KRAS/RAF-RBD Interaction Monitoring (2020)
- Analytical Chemistry
Kari Kopra, Emmiliisa Vuorinen, Maria Abreu-Blanco, Qi Wang, Ville Eskonen, William Gillette, Arto T. Pulliainen, Matthew Holderfield, Harri Härmä
Homogeneous single-label cGMP detection platform for the functional study of nitric oxide-sensitive (soluble) guanylyl cyclases and cGMP-specific phosphodiesterases (2020)
- Scientific Reports
Kari Kopra, Iraida Sharina, Emil Martin, Harri Härmä
Nanomolar Protein-Protein Interaction Monitoring with a Label-Free Protein-Probe Technique (2020)
- Analytical Chemistry
Valtonen S, Vuorinen E, Kariniemi T, Eskonen V, Le Quesne J, Bushell M, Härmä H, Kopra K
Sensitive Label-Free Thermal Stability Assay for Protein Denaturation and Protein-Ligand Interaction Studies (2020)
- Analytical Chemistry
Emmiliisa Vuorinen, Salla Valtonen, Ville Eskonen, Taru Kariniemi, Jelena Jakovleva, Kari Kopra, Harri Härmä
Single-Peptide TR-FRET Detection Platform for Cysteine-Specific Post-Translational Modifications (2020)
- Analytical Chemistry
Eskonen V, Tong-Ochoa N, Mattsson L, Miettinen M, Lastusaari M, Pulliainen AT, Kopra K, Härmä H
High-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors (2019)
- Analytical Biochemistry
Manoharan G.B., Kopra K., Eskonen V., Härmä H., Abankwa D.