Matti Poutanen
PhD
matpou@utu.fi +358 29 450 2632 +358 50 366 0140 Kiinamyllynkatu 10 Turku Työhuone: C507 ORCID-tunniste: https://orcid.org/000-0002-8953-1734 |
geenimuunnellut eläimet, steroidi hormoni, endometrioosi, hormonaalinen syöpä
EDUCATIONAL
TRAINING
1987, M.Sc., Department of Biochemistry, University of
Oulu, Finland
1993, Ph.D., Department of Clinical Chemistry,
University of Oulu, Finland
1997, Title of Docent
(Adjunct professor); Biochemical Endocrinology, University of Oulu, Finland
CURRENT
POSITIONS
Professor, Department of Physiology,
University of Turku, and Director of Turku Center for Disease Modeling,
University of Turku, Finland
Senior Scientist
lecturer, Institute of Medicine, The Sahlgrenska Academy, Gothenburg
University, Gothenburg, Sweden
MAJOR GRANTS:
Academy
of Finland, The Finnish Cancer Organisations, Sigrid Juselius Foundation, Novo
Foundation, Vetenskaps Rådet, Business Finland and Industry
SUPERVISION OF STUDENTS: 30 PhD students supervised, 6 in training.
SCIENTIFIC
AND SOCIETAL IMPACT OFD THE WORK
Research
is mainly focused on sex steroid synthesis and action, with total number of
citation 6270 (Web of Science, April 2018); number of citations in 2017: ~400;
average citations per article: 26.8; h-index: 46; 182 original peer-reviewed
publications; 5 publications in high-impact journals (I.F. ≥ 10): J. Clin. Invest. 2x (I.F. 13), Cell Metab.(I.F. 17), Nat. Med. (I.F.
28), Gut (I.F. 14)
Co-founder, Forendo
Pharma ltd (www.forendo.com) focusing on hormonal therapies for endometriosis
and male hypogonadism. The company has closed its investment rounds with the
leading Nordic start-up investors Karolinska Development AB, Novo Seeds and
Finnvera.
Our research group has been internationally in a key position in
providing evidence for the concept where the ligand concentration available for
steroid hormone receptor binding is markedly regulated by the target tissue
metabolism, termed intracrine steroid
hormone action. The concept has proven to be essential for the growth and
progression of both prostate and breast cancer. We, furthermore, have shown
this concept to be valid also in premenopausal women, eg. in the endometriosis,
and other medically relevant implications are expected to rise in the near
future.
Teaching experience in, endocrinology, developmental biology, hormonal cancer, GM mice and animal models and in vivo imaging
- Ovarian Endometriosis Signatures Established through Discovery and Directed Mass Spectrometry Analysis (2014)
- Journal of Proteome ResearchDevelopment
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A reporter mouse model reveals that human CYP19A1 (aromatase) gene expression is induced in breast cancer xenograft stroma and surrounding mammary gland by the cancer cells in vivo. (2013)
- Cancer Research
(O2 Muu julkaisu ) - FELASA guidelines for the refinement of methods for genotyping genetically-modified rodents (2013)
- Laboratory Animals
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Inactivation of Estrogen Receptor Alpha in Bone Forming Cells Induces Bone Loss in Female Mice (2013)
- FASEB Journal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Inactivation of the androgen receptor in bone-forming cells leads to trabecular bone loss in adult female mice (2013)
- BoneKEy Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Inbred wild type mouse strains have distinct spontaneous morphological phenotypes (2013)
- Histology and Histopathology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - (2013)
- Journal of Mass SpectrometryInternational Journal of Andrology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Seminal vesicles and urinary bladder as sites of aromatization of androgens in men, evidenced by a CYP19A1-driven luciferase reporter mouse and human tissue specimens (2013)
- FASEB Journal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals (2013)
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Comparison of liquid chromatography-microchip/mass spectrometry to conventional liquid chromatography-mass spectrometry for the analysis of steroids (2012)
- Analytica Chimica Acta
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Dicer1 Ablation in the Mouse Epididymis Causes Dedifferentiation of the Epithelium and Imbalance in Sex Steroid Signaling (2012)
- PLoS ONEGynecologic Oncology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Endometrial and endometriotic concentrations of estrone and estradiol are determined by local metabolism rather than circulating levels. (2012)
- Journal of Clinical Endocrinology and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Epididymal protein Rnase10 is required for post-testicular sperma maturation and male fertility (2012)
- FASEB Journal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Estrogen biosynthesis and signaling in endometriosis (2012)
- Molecular and Cellular Endocrinology
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä) - Fibroblast Growth Factor 8b Causes Progressive Stromal and Epithelial Changes in the Epididymis and Degeneration of the Seminiferous Epithelium in the Testis of Transgenic Mice (2012)
- Biology of Reproduction
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - High levels of the extracellular matrix proteoglycan decorin are associated with inhibition of testicular function (2012)
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Improved Statistical Modeling of Tumor Growth and Treatment Effect in Preclinical Animal Studies with Highly Heterogeneous Responses In Vivo (2012)
- Clinical Cancer Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Interactions between inflammatory signals and the progesterone receptor in regulating gene expression in pregnant human uterne myocytes (2012)
- Journal of Cellular and Molecular Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Loss of Bmyc results in increased apoptosis associated with upregulation Myc expression in juvenile murine testis (2012)
- Reproduction
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Serum HE4 concentration is not dependent on menstrual cycle or hormonal treatment among endometriosis patients and healthy premenopausal women (2012)
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )