Matti Poutanen
PhD
matpou@utu.fi +358 29 450 2632 +358 50 366 0140 Kiinamyllynkatu 10 Turku Työhuone: C507 ORCID-tunniste: https://orcid.org/000-0002-8953-1734 |
geenimuunnellut eläimet, steroidi hormoni, endometrioosi, hormonaalinen syöpä
EDUCATIONAL
TRAINING
1987, M.Sc., Department of Biochemistry, University of
Oulu, Finland
1993, Ph.D., Department of Clinical Chemistry,
University of Oulu, Finland
1997, Title of Docent
(Adjunct professor); Biochemical Endocrinology, University of Oulu, Finland
CURRENT
POSITIONS
Professor, Department of Physiology,
University of Turku, and Director of Turku Center for Disease Modeling,
University of Turku, Finland
Senior Scientist
lecturer, Institute of Medicine, The Sahlgrenska Academy, Gothenburg
University, Gothenburg, Sweden
MAJOR GRANTS:
Academy
of Finland, The Finnish Cancer Organisations, Sigrid Juselius Foundation, Novo
Foundation, Vetenskaps Rådet, Business Finland and Industry
SUPERVISION OF STUDENTS: 30 PhD students supervised, 6 in training.
SCIENTIFIC
AND SOCIETAL IMPACT OFD THE WORK
Research
is mainly focused on sex steroid synthesis and action, with total number of
citation 6270 (Web of Science, April 2018); number of citations in 2017: ~400;
average citations per article: 26.8; h-index: 46; 182 original peer-reviewed
publications; 5 publications in high-impact journals (I.F. ≥ 10): J. Clin. Invest. 2x (I.F. 13), Cell Metab.(I.F. 17), Nat. Med. (I.F.
28), Gut (I.F. 14)
Co-founder, Forendo
Pharma ltd (www.forendo.com) focusing on hormonal therapies for endometriosis
and male hypogonadism. The company has closed its investment rounds with the
leading Nordic start-up investors Karolinska Development AB, Novo Seeds and
Finnvera.
Our research group has been internationally in a key position in
providing evidence for the concept where the ligand concentration available for
steroid hormone receptor binding is markedly regulated by the target tissue
metabolism, termed intracrine steroid
hormone action. The concept has proven to be essential for the growth and
progression of both prostate and breast cancer. We, furthermore, have shown
this concept to be valid also in premenopausal women, eg. in the endometriosis,
and other medically relevant implications are expected to rise in the near
future.
Teaching experience in, endocrinology, developmental biology, hormonal cancer, GM mice and animal models and in vivo imaging
- ErbB4, a receptor tyrosine kinase, coordinates organization of the seminiferous tubules in the developing testis. (2014)
- Molecular Endocrinology -Baltimore-
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Human Testicular Peritubular Cells Host Putative Stem Leydig Cells With Steroidogenic Capacity (2014)
- Journal of Clinical Endocrinology and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Intra-Tissue Steroid Profiling Indicates Differential Progesterone and Testosterone Metabolism in the Endometrium and Endometriosis Lesions (2014)
- Journal of Clinical Endocrinology and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures. (2014)
- Nature Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Ovarian Endometriosis Signatures Established through Discovery and Directed Mass Spectrometry Analysis (2014)
- Journal of Proteome Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A reporter mouse model reveals that human CYP19A1 (aromatase) gene expression is induced in breast cancer xenograft stroma and surrounding mammary gland by the cancer cells in vivo. (2013)
- Cancer Research
(O2 Muu julkaisu ) - FELASA guidelines for the refinement of methods for genotyping genetically-modified rodents (2013)
- Laboratory Animals
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Inactivation of Estrogen Receptor Alpha in Bone Forming Cells Induces Bone Loss in Female Mice (2013)
- FASEB Journal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Inactivation of the androgen receptor in bone-forming cells leads to trabecular bone loss in adult female mice (2013)
- BoneKEy Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Inbred wild type mouse strains have distinct spontaneous morphological phenotypes (2013)
- Histology and Histopathology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
