Muhammad Ashraf
M.Sc.
muwaas@utu.fi |
Pharmacokinetics
Clinical Pharmacokinetics
Pharmacokinetic-Pharmacodynamic Modeling
Population PK/PD
Non-linear Mixed Effects Modeling
NONMEM
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Education:
1. Ph.D. Drug Research Doctoral Programme (DRDP)
01/10/2016 - Present
Department of Anesthesiology and Intensive Care, University of Turku, Turku, Finland.
2. M.Sc. General Toxicology
01/09/2013 - 06/01/2016
University of Eastern Finland, Kuopio Finland.
3. Doctor of Pharmacy (Pharm.D)
14/02/2007 - 30/04/2012
Riphah International University, Islamabad Pakistan.
Work Experience:
1. Project Researcher
01/10/16 - Present
Turku University Hospital, Turku Finland.
2. Lecturer (Clinical Pharmacy/Biopharm and Pharmacokinetics)
14/02/12 - 01/08/13
University of Lahore, Islamabad Campus, Islamabad Pakistan.
I am working in the field of pharmacometrics, where I use the 'population approach' (i.e. non-linear mixed effects modeling) to describe the pharmacokinetic (PK) and/or pharmacokinetic-pharmacodynamic (PK-PD) behaviors of drugs in the human body. I am applying these concepts to data from ongoing clinical trials, that are being actively carried out at the Turku University Hospital, with anesthetic agents and pain medications. The rationale is to elucidate the optimal dosing schemes for these drugs for use in pain medicine, in an attempt to implement precision medicine in this area of medical care provision.
Pharmacology
Clinical Pharmacology
Pharmacokinetics
Population PK/PD Modeling
- Population Pharmacokinetic Quantification of CYP2D6 Activity in Codeine Metabolism in Ambulatory Surgical Patients for Model-Informed Precision Dosing (2024)
- Clinical Pharmacokinetics
- Population Modelling of Dexmedetomidine Pharmacokinetics and Haemodynamic Effects After Intravenous and Subcutaneous Administration (2020)
- Clinical Pharmacokinetics
- Semimechanistic Population Pharmacokinetic Model to Predict the Drug–Drug Interaction Between S-ketamine and Ticlopidine in Healthy Human Volunteers (2018)
- CPT: Pharmacometrics and Systems Pharmacology